Comparison of Different Antibiotics in the Treatment of Acute Gonorrhoea in African Negroes

Clarke, G. H. V.

doi:10.1136/sti.40.2.122

Cited by 5 publications

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“…In West Africa, although 99 % of 74 gonococcal strains were found to be 'fully sensitive ' in 1961(World Health Organisation, 1963, Clarke (1964) working in Lagos, encountered treatment failure in 21-4 % of patients who received procaine penicillin 2-4 megaunits daily for three consecutive days although no sensitivity tests were performed. In Yaunde, Cameroons, Millan and Huet (1970), using a disc diffusion method, reported that 10 of their 18 gonococcal strains were 'sensitive' in penicillin.…”

Section: Resultsmentioning

confidence: 99%

Sensitivity pattern of Neisseria gonorrhoeae to penicillin and screening for -lactamase production in Ibadan, Nigeria

Osoba

Montefiore

Sogbetun

et al. 1977

Sexually Transmitted Infections

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SUMMARY The few reports from Africa on sensitivity determinations of Neisseria gonorrhoeae suggest that there is an increasing resistance in the strains, as has been found in other parts of the world. In the current study, the penicillin sensitivities and p-lactamase production of 80 consecutive strains of N. gonorrhoeae isolated from cases of acute urethritis in African men in Ibadan were studied. Of these strains, 17-5 % had a penicillin minimum inhibitory concentration (MIC) of 0-038 ,ug/ml or less and were considered as being 'fully sensitive'. However, 82-5 % had an MIC of 0 075 jig penicillin/ml or more, and were considered as having 'diminished sensitivity' to penicillin.It was thought that this high incidence of relatively insensitive strains was owing to the sequential selection of these strains because of the easy availability and abuse of antimicrobial agents by the general population. Furthermore, 13 strains (16.25%) demonstrated high level resistance with MIC values of over 0-6 tig penicillin per ml and it is probable that many of the strains will demonstrate multiresistance to the commonly misused antimicrobial agents. Consequently, treatment of patients harbouring these strains may present problems because of financial constraints of the health services in purchasing the appropriate antibiotics. Despite the high level resistance of the strains in an environment of intensive penicillin and ampicillin use, none of the strains studied showed any evidence of p-lactamase production. Nevertheless, continuous surveillance of r-lactamase production by the gonococcus is recommended in the larger medical centres in developing countries.

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