New Antibiotics

Brogden, Rex N.; Avery, G. S.

doi:10.2165/00003495-197203050-00002

Cited by 13 publications

(2 citation statements)

References 26 publications

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“…Rifampicin [45] 1968 Tobramycin [33] 1968 Trimethoprim/sulph [41] 1970 Ticarcillin [46] 1971 Minocycline [47] 1971 Mupirocin [48,49] 1972 Amoxycillin [42] 1975 Netilmicin [33] 1976 Amikacinv [33] 1977 Cefoxitin [50] 1978 Cefadroxil [51] 1979…”

Section: Quality and Antibiotic Resistance Of Bacterial Aerosol (Ba) mentioning

confidence: 99%

Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

2020

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International interests in biological air pollutants have increased rapidly to broaden the pool of knowledge on their identification and health impacts (e.g., infectious, respiratory diseases and allergies). Antibiotic resistance and its wider implications present us with a growing healthcare crisis, and an increased understanding of antibiotic-resistant bacteria populations should enable better interpretation of bioaerosol exposure found in the air. Waste sorting plant (WSP) activities are a source of occupational bacterial exposures that are associated with many health disorders. The objectives of this study were (a) to assess bacterial air quality (BAQ) in two cabins of a WSP: preliminary manual sorting cabin (PSP) and purification manual sorting cabin (quality control) (QCSP), (b) determine the particle size distribution (PSD) of bacterial aerosol (BA) in PSP, QCSP, and in the outdoor air (OUT), and (c) determine the antibiotic resistance of isolated strains of bacteria. Bacterial strains were identified on a Biolog GEN III (Biolog, Hayward, CA, USA), and disc diffusion method for antimicrobial susceptibility testing was carried out according to the Kirby–Bauer Disk Diffusion Susceptibility Test Protocol. A large share of fecal bacteria, Enterococcus faecalis and Alcaligenes faecalis spp. feacalis, was found in the tested indoor air, which is a potential health hazard to the workers of the monitored WSP. Our results demonstrate the necessity to take into account fecal air pollution levels to avoid making erroneous assumptions regarding the environmental selection of antibiotic resistance. Total elimination of many anthropogenic sources is not possible, but important findings of this study can be used to develop realistic management policies methods to improve BAQ.

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Section: Quality and Antibiotic Resistance Of Bacterial Aerosol (Ba) mentioning

confidence: 99%

Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

2020

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“…Classic pharmacokinetics studies examine the macroscopic processes of drug absorption, distribution, metabolism, and excretion in the body [1][2][3], and determine the rate and degree of drug absorption by measuring the plasma drug concentration [4], calculating the bioavailability of the drug [5], then judge the pros and cons of the pharmacokinetic properties of the drug [6,7]. However, the current mainstream method of measuring plasma drug concentration is still the traditional medical method to extract drug concentration data in plasma and various tissues.…”

Section: Introductionmentioning

confidence: 99%

Multi-channel Small Animal Drug Metabolism Real-time Monitoring Fluorescence System

Qian¹

2023

Preprint

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Purpose The data acquisition of drug metabolism analysis requires a lot of time and animal resources. However, there are often many deviations in the results of pharmacokinetic analysis. Conventional methods cannot measure the blood drug concentration data in multiple tissues at the same time, and the data is obtained by in vitro measurement, which produces time errors, in vitro data errors, and individual differences between animals. In the analysis of pharmacokinetic parameters, it will seriously affect the pass rate of clinical trials of R&D drugs and the accuracy of the dosing schedule. To the best of our knowledge, we have not found the study of in vivo blood drug concentration using multi-channel equipment. Therefore, the purpose of this paper is to build a set of multi organ monitoring and analysis instruments for synchronously monitoring the metabolism of drugs in various tissues of small animals, so as to obtain real in vivo data of blood drug concentration in real time. Procedures Using the fluorescence properties and Laser-induced fluorescence principle of drugs, we designed six channels to monitor the changes of fluorescence-labeled drugs in their main metabolic organs, a multi-channel calibration method was proposed to improve the accuracy of the Time-division multiplexing, the real-time collection of drug concentration in vivo is realized and the drug metabolism curve in vivo can be observed. Results The instrument satisfies the collection of small doses of drugs such as ug, the detection sensitivity can reach 10 ng/ml, and can monitor and collect the drug metabolism of multiple small animal tissues at the same time, which greatly reduces the use of animals, reduces the differences between individuals, and reduces consumption cost and improve the detection efficiency of parameters, and obtain data information that is closer to the real biology. Conclusion Realized the real-time continuous monitoring and data collection of the drug metabolism in the plasma of living small animals and the important organs such as kidney, liver and spleen. The research and development of new drugs and clinical research have higher practical value.

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Pharmacokinetic data on sulphonamides and other antibacterials

Jack¹

1992

Handbook of Clinical Pharmacokinetic Data

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New Antibiotics

Cited by 13 publications

References 26 publications

Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

Multi-channel Small Animal Drug Metabolism Real-time Monitoring Fluorescence System

Pharmacokinetic data on sulphonamides and other antibacterials

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