Comparison of Diclofenac and Fluorometholone in Preventing Cystoid Macular Edema After Small Incision Cataract Surgery A Multicentered Prospective Trial

Laser flare photometry and its use in uveitis

“…LFP studies have shown that topical diclofenac, a nonsteroidal anti-inflammatory drug, is as effective as topical dexamethasone [60][61][62] and more effective than fluorometholone [63] or betamethasone [64] in preventing disruption of blood-aqueous barrier following intraocular surgery.…”

Impact of nepafenac 0.1% on macular thickness and postoperative visual acuity after cataract surgery in patients at low risk for cystoid macular oedema

“…Prospective studies evaluated the effect of a postoperative NSAID on the development of macular oedema after phacoemulsification. 7,[17][18][19] At 5 weeks after phacoemulsification, Miyake's study documented 5.7 vs 54.7% angiographic CME in the eyes that received only diclofenac 0.1% vs the eyes that received only flurometholone 0.1%, respectively. 7 Two recent studies confirmed these findings when an NSAID was used preoperatively and postoperatively.…”

“…5,6 To our knowledge, the only prospective study supporting this statement is Miyake's study, because this study measured visual acuity and assessed for macular oedema in all subjects. 7 To help define standard of care for the use of a topical NSAID after routine phacoemulsification, our prospective, randomised study evaluated best-corrected visual acuity (BCVA) and macular thickness measured by OCT.…”

Macular Edema and Cataract Surgery

“…Cytokines such as interferon-γ, interleukin-2 and tumor necrosis factor-α also participate in the proccess inducing the production of cycloxygenase. (Wakefield & Lloyd, 1992;Miyake et al, 2000). Experimental studies of lens implantation in animal models have confirmed that trauma of the lens epithelial cells leads to the secretion of inflammatory mediators (Miyake et al, 1990).…”