Comparison of diagnostic and prognostic capabilities of 18F-FDG-PET/CT, 131I-scintigraphy, and diffusion-weighted magnetic resonance imaging for postoperative thyroid cancer

Nagamachi, Shigeki; Wakamatsu, Hideyuki; Kiyohara, Shogo; Nishii, Ryuichi; Mizutani, Youichi; Fujita, Seigo; Futami, Shigemi; Arita, Hideo; Kuroki, M; Uchino, Noriko; Tamura, Shozo; Kawai, Keiichi

doi:10.1007/s11604-011-0572-z

Cited by 26 publications

(27 citation statements)

References 44 publications

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“…It was quickly outperformed by FDG-PET/CT, which combined the advantages of metabolic and morphologic imaging and thus allowed for improved anatomic localization and correlation of focal metabolic activity. FDG-PET/CT is now commonly accepted as the method of choice for post-thyroidectomy patients with increased Tg blood levels and negative I-WBS [11, 12, 15–18]. For distant metastases, particularly of the lung and bones, FDG-PET/CT reaches both sensitivity and specificity up to 1.00 [14, 15, 19].…”

Section: Introductionmentioning

confidence: 99%

“…FDG-PET/CT is now commonly accepted as the method of choice for post-thyroidectomy patients with increased Tg blood levels and negative I-WBS [11, 12, 15–18]. For distant metastases, particularly of the lung and bones, FDG-PET/CT reaches both sensitivity and specificity up to 1.00 [14, 15, 19]. Nonetheless, the sensitivity and specificity of FDG-PET/CT for detecting locally recurrent or metastatic TC is still relatively low and ranges between 0.46 to 1.00 and 0.66 to 1.00, respectively [5, 12, 17].…”

Section: Introductionmentioning

confidence: 99%

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Impact of combined FDG-PET/CT and MRI on the detection of local recurrence and nodal metastases in thyroid cancer

et al. 2016

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BackgroundSuspected recurrence of thyroid carcinoma is a diagnostic challenge when findings of both a radio iodine whole body scan and ultrasound are negative. PET/CT and MRI have shown to be feasible for detection of recurrent disease. However, the added value of a consensus reading by the radiologist and the nuclear medicine physician, which has been deemed to be helpful in clinical routines, has not been investigated. This study aimed to investigate the impact of combined FDG-PET/ldCT and MRI on detection of locally recurrent TC and nodal metastases in high-risk patients with special focus on the value of the multidisciplinary consensus reading.Materials and methodsForty-six patients with suspected locally recurrent thyroid cancer or nodal metastases after thyroidectomy and radio-iodine therapy were retrospectively selected for analysis. Inclusion criteria comprised elevated thyroglobulin blood levels, a negative ultrasound, negative iodine whole body scan, as well as combined FDG-PET/ldCT and MRI examinations.Neck compartments in FDG-PET/ldCT and MRI examinations were independently analyzed by two blinded observers for local recurrence and nodal metastases of thyroid cancer. Consecutively, the scans were read in consensus. To explore a possible synergistic effect, FDG-PET/ldCT and MRI results were combined. Histopathology or long-term follow-up served as a gold standard.For method comparison, sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy were calculated.ResultsFDG-PET/ldCT was substantially more sensitive and more specific than MRI in detection of both local recurrence and nodal metastases. Inter-observer agreement was substantial both for local recurrence (κ = 0.71) and nodal metastasis (κ = 0.63) detection in FDG-PET/ldCT. For MRI, inter-observer agreement was substantial for local recurrence (κ = 0.69) and moderate for nodal metastasis (κ = 0.55) detection. In contrast, FDG-PET/ldCT and MRI showed only slight agreement (κ = 0.21). However, both imaging modalities identified different true positive results. Thus, the combination created a synergistic effect. The multidisciplinary consensus reading further increased sensitivity, specificity, and diagnostic accuracy.ConclusionsFDG-PET/ldCT and MRI are complementary imaging modalities and should be combined to improve detection of local recurrence and nodal metastases of thyroid cancer in high-risk patients. The multidisciplinary consensus reading is a key element in the diagnostic approach.Electronic supplementary materialThe online version of this article (doi:10.1186/s40644-016-0096-y) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of combined FDG-PET/CT and MRI on the detection of local recurrence and nodal metastases in thyroid cancer

et al. 2016

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“…The complementary role of these methods was confirmed by Nagamachi et al [38] who, in 70 patients, compared the capacity of 131 I-WBS and 18 FDG PET/CT to detect postoperative DTC metastases. On the patient-basis analysis, the detectability by 131 I WBS and 18 FDG PET/CT was 67.1 and 84.2 %, respectively.…”

Section: Direct Comparisons Of Diagnostic Accuracymentioning

confidence: 90%

“…131 I-WBS provided information complementary to that provided by 18 FDG PET/CT in 11 of the 70 (15.7 %) cases. On the organ-basis analysis, 131 I WBS was found to be the best detector of lymph node metastases (72.4 %), while 18 FDG PET/CT was superior to 131 I WBS for detecting bone metastases (85.7 versus 71.4 %, respectively) and lung metastases (94.1 versus 62.7 %, respectively) [38].…”

Section: Direct Comparisons Of Diagnostic Accuracymentioning

confidence: 97%

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131I whole-body scan or 18FDG PET/CT for patients with elevated thyroglobulin and negative ultrasound?

Treglia

Bertagna

Piccardo

et al. 2013

Clin Transl Imaging

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The aim of this review is to discuss the current role of iodine-131 (131 I) whole-body scanning (WBS) and fluorine-18-fluorodeoxyglucose positron emission tomography (18 FDG PET) or PET/computed tomography (PET/ CT) in the restaging of differentiated thyroid cancer (DTC), prompted by increasing thyroglobulin serum levels in patients with negative neck ultrasound. Studies in the literature which compared these two imaging methods are discussed in depth. 18 FDG PET or PET/CT and 131 I WBS may provide complementary information useful for the restaging of DTC patients, and the combined use of these methods should thus be considered to identify recurrent/ metastatic DTC patients after total thyroidectomy. The accuracy of 18 FDG PET/CT seems to be superior to that of 131 I WBS and SPECT/CT in high-risk DTC.

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Correlation between tissue metabolism and cellularity assessed by standardized uptake value and apparent diffusion coefficient in peritoneal metastasis

Lee

Lai

et al. 2013

Magnetic Resonance Imaging

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Comparison of diagnostic and prognostic capabilities of 18F-FDG-PET/CT, 131I-scintigraphy, and diffusion-weighted magnetic resonance imaging for postoperative thyroid cancer

Cited by 26 publications

References 44 publications

Impact of combined FDG-PET/CT and MRI on the detection of local recurrence and nodal metastases in thyroid cancer

Impact of combined FDG-PET/CT and MRI on the detection of local recurrence and nodal metastases in thyroid cancer

131I whole-body scan or 18FDG PET/CT for patients with elevated thyroglobulin and negative ultrasound?

Correlation between tissue metabolism and cellularity assessed by standardized uptake value and apparent diffusion coefficient in peritoneal metastasis

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