Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation

Jain, Vaibhav; Chandak, Aruna; Ghosh, Alok; Golhar, Mayuri

doi:10.4103/1687-7934.156699

Cited by 13 publications

(17 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study dexmedetomidine had better control on HR as compared to fentanyl. Jain et al 4 compared dexmedetomidine 1 mcg/kg and fentanyl 2 mcg/kg, dose similar to our study. They found postintubation HR value increased in both the groups when compared to postinduction values but in dexmedetomidine group HR was lower than the baseline value whereas in fentanyl group the postintubation values were higher than the baseline values.…”

Section: Discussionsupporting

confidence: 69%

“…There are studies in which the dose of dexmedetomidine ranges from 0.1 to 10 mcg/kg/hr, but the higher doses have been associated with bradycardia and hypotension. 18,19 Ozair et al 9 and Jain et al 4 in their studies of comparison of dexmedetomidine and fentanyl found the use of dexmedetomidine in the dose of 1 mcg/kg to be effective in controlling the pressor response to intubation without significant side effects. Taking these studies as references we gave dexmedetomidine in the dose of 1 mcg/kg in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically relevant bradycardia was defined as heart rate < 50 b eats/min and was treated with atropine 0.6 mg intravenously. Sample size calculation was done by the following formula Number of cases in each group (n) = 2(z α +z β ) 2 S 2 /d 2 On the basis of study done by Jain et al, 4 the mean std deviation of heart rate at 5 min after intubation was 6.96 and the difference in mean was 7.57. Sample size (n) = 2 ( 1.96 + 1.28) 2 (6.96) 2 /(7.57) 2 = 17.73.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Comparative Study of Dexmedetomidine and Fentanyl for Attenuation of Hemodynamic Response to Laryngoscopy and Intubation

Gauchan

Thapa

2019

J Coll Med Sci-Nepal

View full text Add to dashboard Cite

Background: Laryngoscopy and intubation cause hypertension and tachycardia which can lead to myocardial ischemia or cerebrovascular hemorrhage in patients with raised intracranial pressure, hypertension. The objective of this study was to compare the efficacy of dexmedetomidine (1 mcg/kg) and fentanyl (2 mcg/kg) in attenuating hemodynamic response to laryngoscopy and intubation. Methods: Sixty patients scheduled for elective surgeries under general anaesthesia were randomly divided into two groups: Group D and Group F. Group D received dexmedetomidine 1 mcg/kg and group F received fentanyl 2 mcg/kg intravenously over 10 min prior to induction of anesthesia. All the drugs and techniques of anesthesia were standardized in patients in both the groups. Heart rate, systolic, diastolic and mean arterial pressure were recorded at following intervals: at baseline, after drug administration (at 2 and 5 min), after induction, and at 1, 2 and 5 min after intubation. Results: Heart rate and blood pressure was found to be significantly lower in dexmedetomidine group as compared to fentanyl group at 1, 2 and 5 min after intubation. Conclusions: Dexmedetomidine 1 mcg/kg is superior to fentanyl 2 mcg/kg for attenuation of hemodynamic response to laryngoscopy and intubation.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study of Dexmedetomidine and Fentanyl for Attenuation of Hemodynamic Response to Laryngoscopy and Intubation

Gauchan

Thapa

2019

J Coll Med Sci-Nepal

View full text Add to dashboard Cite

show abstract

“…Viabhav Jan et al 18 in 2015 their study compared the efficacy of dexmedetomidine and fentanyl for attenuation of laryngoscopic pressor response. Group-D patients received an injection of dexmedetomidine at a dose of 1 mcg/kg, whereas Group-F received fentanyl at a dose of 2 mcg/kg preoperatively over 10 minutes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Dexmedetomidine With Fentanyl in Attenuation of Pressor Response to Laryngoscopy and Intubation

Natta¹,

Dasari²,

B³

2017

jebmh

View full text Add to dashboard Cite

BACKGROUND Direct laryngoscopy and endotracheal intubation elicits a haemodynamic response associated with increased heart rate and blood pressure. The aim of the study is to compare the efficacy of intravenous dexmedetomidine and fentanyl in attenuation of stress response to laryngoscopy and intubation. MATERIALS AND METHODS Study was carried out on 60 patients belonging to ASA grade I & II, aged 15 to 65 years including either gender scheduled for elective surgical procedures under general anaesthesia in Osmania General Hospital. Patients were randomly divided into two groups of 30 each. Group D received 0.6g/kg dexmedetomidine and Group F received 2 g/kg fentanyl diluted in 10 mL normal saline 10 minutes before laryngoscopy and intubation. Anaesthesia was standardised in both groups and vital parameters heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded preoperatively, during intubation and up to 10 minutes after intubation. RESULTS The groups were well matched for their demographic data. It was observed that increase in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure after intubation was highly significant in fentanyl group as compared to dexmedetomidine. There was a statistically significant difference (P <0.05) between dexmedetomidine and fentanyl groups in heart rate, systolic, diastolic blood pressure and mean arterial pressure at all time points after tracheal intubation. CONCLUSION Both the drugs attenuated the pressor response. Among the two drugs administered dexmedetomidine 0.6 µg/kg provides reliable and effective attenuation of pressor response to laryngoscopy and tracheal intubation when compared to fentanyl in a dose of 2 µg/kg.

show abstract

“…It is found that intravenous dexmedetomidine is more effective in attenuating the hemodynamic response to laryngoscopy and intubation than other agents [3,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Samal

Pattnaik

Swain

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The airway instrumentation of direct laryngoscopy and tracheal intubation is powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction, and rapid intubation. This study compared the efficacy intravenous dexmedetomidine and oral pregabalin premedication for attenuation of hemodynamic pressor response to laryngoscopy and intubation.Methods: A total of 60 patients of age group 20-50 years scheduled for elective surgeries under general anesthesia with American Society of Anesthesiologists physical Status I and II were divided into two groups each of 30. Group D received intravenous dexmedetomidine 1 mcg/kg over 10 minutes before induction, and Group P received oral pregabalin 150 mg 1 hr before intubation. Parameters observed were heart rate (HR) and mean arterial pressure (MAP) at baseline, after induction, immediately after intubation and then 5, 10, 15, and 30 minutes thereafter.Results: Attenuation of HR in group dexmedetomidine (78.12±10.0/minutes) immediately after intubation was statistically significant than group pregabalin (89.76±10.45/minutes). MAP significantly (p<0.05) decreased after intubation with dexmedetomidine. As compared to oral pregabalin, attenuation of HR and MAP was statistically significant till 30 minutes after intubation with intravenous dexmedetomidine. Conclusion:Intravenous dexmedetomidine 1 µg/kg is more effective than oral pregabalin 150 mg in attenuating hemodynamic response to laryngoscopy and orotracheal intubation.

show abstract

Comparison of dexmedetomidine and fentanyl for attenuation of the hemodynamic response to laryngoscopy and tracheal intubation

Cited by 13 publications

References 0 publications

Comparative Study of Dexmedetomidine and Fentanyl for Attenuation of Hemodynamic Response to Laryngoscopy and Intubation

Comparative Study of Dexmedetomidine and Fentanyl for Attenuation of Hemodynamic Response to Laryngoscopy and Intubation

Comparison of Dexmedetomidine With Fentanyl in Attenuation of Pressor Response to Laryngoscopy and Intubation

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Contact Info

Product

Resources

About