Comparison of Desipramine and Imipramine in Depression

Rose, J. T.; Westhead, T. T.

doi:10.1176/ajp.121.5.496

Cited by 10 publications

(3 citation statements)

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“…This is in accordance with other groups using the HRS total score for such classification of patients. 17 3. The sum of concentrations of imipramine and desipramine should be calculated after multiplying the concentration value of one of the compounds with factors from 0.1 to 10.…”

Section: Antidepressant Levels Of Imipramine 321mentioning

confidence: 99%

“…13 It might, therefore, be hypothesized that effects on both serotonin and noradrenalin transmitters are needed for the clinical antidepressive effect. However, the fact that desipramine per se has antidepressive effect 17 indicates that the interaction between imipramine and desipramine is more complex. The antidepressive effect of desipramine has, on the other hand, been claimed to be weaker than that of other tricyclic antidepressants.…”

Section: Antidepressant Levels Of Imipramine 323mentioning

confidence: 99%

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Plasma levels and antidepressive effect of imipramine

Gram

Reisby

Ibsen

et al. 1976

Clin Pharma and Therapeutics

125

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The relationship between the antidepressive effect of imipramine and the plasma concentrations of imipramine and the active metabolite desipramine was studied in 24 patients suffering from endogenous depression. After a placebo period of 7 days, the patients received imipramine, 75 mg 3 times a day. The dose was reduced in patients with pronounced side effects. Blood samples for drug assay were drawn in the morning, 15 hr after the last drug intake. Imipramine and desipramine in plasma were assayed by quantitative in situ thin-layer chromatography. Individual variations in plasma concentration were 20- to 30-fold in both imipramine and desipramine. Severity of depression was assessed on the Hamilton Rating Scale (HRS). Eleven of 12 patients who responded satisfactorily to the treatment (HRS post-treatment score less than 8) had plasma concentration of imipramine greater than or equal to 45 mug/L, and desipramine greater than 75 mug/L, whereas the 12 patients not responding satisfactorily (post-treatment score on HRS greater than or equal to 8) all had concentrations of imipramine or desipramine or both below these limits.

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Section: Antidepressant Levels Of Imipramine 321mentioning

confidence: 99%

Section: Antidepressant Levels Of Imipramine 323mentioning

confidence: 99%

Plasma levels and antidepressive effect of imipramine

Gram

Reisby

Ibsen

et al. 1976

Clin Pharma and Therapeutics

125

View full text Add to dashboard Cite

show abstract

“…Not only is clozapine a potent antagonist for D4 receptor, it is so for D I , Dz, a,-adrenergic, 5HTz serotonergic, cholinergic, histaminergic, etc (Tamminga and Gerlach, 1987). Typical neuroleptics such as chlorpromazine or haloperidol are also Rose and Westhead, 1964Lauritsen and Madsen, 1974Rickels er al., 1981Santonastaso et al, 1979Stassen et al, 1993Lecrubier et af., 1980Brogden et a/., 1978Angst et al, 1977Kampman et al. 1978Montgomery et al, 1981Laursen et af., 1985Gravem et al, 1987Dominguez et al, 1985Bremner, 1984Reimherr et al, 1990Naylor and Martin, 1985Dahl et al, 1982LOO et al.…”

mentioning

confidence: 99%