Multiple approaches in neuronal activity for treating depression: More effective, more types of receptors?

Contradirect effects on neuronal activity in treating depression

“…The antidepressant activities of drugs which act on many neuron systems have been explored by controlled trials (Okada and Tokumitsu, 1995). For example, drugs which act on monoaminergic neuron systems, such as adrenergic, serotonergic, and dopaminergic systems, as well as GABAnergic and peptidergic neuron systems, are recognised to be ecacious for treating depression.…”

“…For example, drugs which act on monoaminergic neuron systems, such as adrenergic, serotonergic, and dopaminergic systems, as well as GABAnergic and peptidergic neuron systems, are recognised to be ecacious for treating depression. Therefore, some functional abnormalities in these neuronal systems have been assumed to be related to the pathogenesis of depression (Okada and Tokumitsu, 1994). Recently, it has been thought that immunological abnormalities might be related to the pathogenesis of depression, since depression is sometimes caused by interferon therapy (Okada, 1995a).…”