Comparison of Cytoprotective Effects of Saponins Isolated from Leaves of Aralia elata SEEM. (Araliaceae) with Synthesized Bisdesmosides of Oleanoic Acid and Hederagenin on Carbon Tetrachloride-Induced Hepatic Injury.

Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata

“…Five subfractions (nos. 6,10,11,14,15) did not need to be tested, because each was a mixture of the adjacent subfractions on silica gel TLC plates, and four fractions (nos. 1, 2, 9, 18) could not be tested, because the quantities obtained from the butanol fraction were too small.…”

Saponins and Other Constituents from the Leaves of Aralia elata

“…Many saponins have been isolated from this plant, [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] and were reported to show anti-diabetic activity, 17) cytoprotective effect on CCl 4 -induced hepatic injury, 7) ethanol absorption inhibitory effect, 6,14) and hypoglycemic activity. 10-12) Recently, we reported the isolation and identification of various triterpenoid saponins including two new saponins, durupcosides A and B, 2,3) and a cerebroside, aralia cerebroside 18) from the root bark of this plant.…”

“…As part of our continuing search for antiinflammatory agents from plants, 19) a nonpolar n-hexane extract of the leaves of A. elata was subjected to a chemical investigation leading to the isolation of eight compounds, among which one was new. This paper deals with the isolation and characterization of the new triterpenoid saponin named durupcoside C (5), together with five known saponins (1-4, 6) and two known lipids (7,8) from the n-hexane fraction of the leaves of A. elata.…”

“…Six saponins (1)(2)(3)(4)(5)(6) and two lipids (7,8) were isolated by successive chromatography using silica and reverse-phase C 18 from the n-hexane fraction. Five known saponins and two lipids were identified as a-hederin (1), 20) collinsonidin (2), 21) 4) urtica ceramides (7) 23) and arisaema glyceride 3 (8), 24) respectively, by direct comparison of the spectral data with the published values.…”

“…23) Other lipid component (8) was identified as arisaema glyceride 3 by comparison of its NMR, MS spectra, and optical rotation data with an authentic sample from Arisaema amurense. 24) Collinsonidin (2) and two known lipids (7,8) were isolated for the first time from this plant.…”