Comparison of cytologic features of giant‐cell tumor and giant‐cell tumor of tendon sheath

Abstract

The cytologic features in twelve cases of giant-cell tumor (GCT) and five cases of giant-cell tumor of tendon sheath (GCTTS) diagnosed by fine-needle aspiration cytology (FNAC) are described. All of these cases were histopathologically confirmed. The aspirates of GCT are composed of a dual population of mononucleated spindle cell and multinucleated giant cells. The peripheral adherence of giant cells to the spindle cell is the feature of diagnostic significance in GCT. In GCTTS, the aspirate consists of a polymorphic population composed of mononuclear histiocyte-like cells, hemosiderin laden macrophages, foamy macrophages, and a few multinucleated giant cells. FNAC can be used as a diagnostic tool for an early and accurate detection of these two giant cell-rich lesions, since the cytologic features when evaluated in conjunction with the clinical and radiologic features are sufficiently diagnostic.

Fine Needle Aspiration Cytology of Diffuse-Type Tenosynovial Giant Cell Tumors

“…Osteosarcoma can have multinucleated osteoclasts but typically shows overt cellular features of malignancy and sometimes osteoid. Pleomorphic sarcoma generally shows marked cytological atypia with conspicuous mitotic figures [11,12,15] . Correlation with radiological features is also helpful in distinguishing these lesions with multinucleated giant cells.…”

Giant cell tumor of tendon sheath—Use of fine-needle aspiration cytology for diagnosis

“…In GCTTs, FNAC shows a polymorphic population composed of mononuclear histiocyte-like cells, hemosiderin-laden macrophages, foamy macrophages and a few multinucleated giant cells [7,8] . FNAC can be used as a diagnostic tool for an early and accurate detection of GCTTs as the cytological features, and clinico-radiological correlation are sufficiently diagnostic [7,8] . Thus, FNAC helps in preoperative planning to prevent recurrence [8] .…”

“…differential diagnoses of GCTTs include ganglion, lipoma, foreign body granuloma, tophaceous gout, haemangioma, glomus tumour, enchondroma, osteoid osteoma, osteoblastoma, schwannoma, and circum scribed fibromatosis [6] . due to its location in the extremities, GCTTs also needs to be differentiated from epithelioid sarcoma, synovial sarcoma, clear-cell sarcoma, and rhabdomyosarcoma [7] . Osteoclast-type giant cells are normally absent in each of these four neoplasms, but they are frequently present in GCTTs [7] .…”

“…due to its location in the extremities, GCTTs also needs to be differentiated from epithelioid sarcoma, synovial sarcoma, clear-cell sarcoma, and rhabdomyosarcoma [7] . Osteoclast-type giant cells are normally absent in each of these four neoplasms, but they are frequently present in GCTTs [7] . We report this case to highlight the role of FNAC in diagnosing GCTTs.…”

Fine Needle Aspiration Biopsy in Central Giant Cell Lesion

“…1 Especially in CGCL, it is a useful method, but few articles describe its use in the English-language literature. 1,4,10 In this article we report 3 CGCL cases diagnosed initially by FNAB, emphasizing particularly the cytologic and immunocytochemical findings in the aspirates.…”