Comparison of Cytokine in Saliva From Oral Cancer Patients and Normal Person

Katakura, Akira; Kamiyama, Ikuo; Takagi, Ryou; Yamada, Mika; Shouno, Takahiro; Takano, Nobuo; Shibahara, Takahiko; Muramatsu, Takaki; Sasaki, Hotaka; Ishihara, Kazuyuki; Ohtsuru, Hiroshi

doi:10.5981/jjhnc.32.45

Cited by 4 publications

(8 citation statements)

References 6 publications

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“…In previous two studies, mean IL-6 concentrations before treatment, as determined by ELISA, in unstimulated saliva from 13 and 19 patients with OSCC, has been reported to be 88.2±43.2 pg/mL and 86.5±84.7 pg/mL, respectively, 17,18 higher than the concentrations we measured in stimulated saliva during periods 1 and 2. These findings suggest that our saliva samples may have been diluted.…”

Section: Discussioncontrasting

confidence: 67%

“…2,4,9 Some previous studies indicated that the concentrations of IL-6 in serum and saliva are significantly elevated in patients with oral neoplastic and preneoplastic lesions as compared with controls. 8,9,[15][16][17][18] Rhodus et al 9 reported that OSCC as well as oral preneoplastic lesions had significantly higher salivary levels of IL-6 than controls. They suggested that the progression of OSCC may be enhanced by the continued expression of the proinflammatory cytokines.…”

Section: Introductionmentioning

confidence: 99%

“…Some researchers suggested that IL-6 in saliva and serum may be a useful biomarker for patient screening. 2,9,18 However, the clinical significance of IL-6 in saliva in patients with OSCC is not clearly understood. Since previous studies reported only baseline salivary IL-6 concentrations, 2,9,15,18 it is also uncertain whether IL-6 in saliva would change depending on the various treatment phases.…”

Section: Introductionmentioning

confidence: 99%

“…2,9,18 However, the clinical significance of IL-6 in saliva in patients with OSCC is not clearly understood. Since previous studies reported only baseline salivary IL-6 concentrations, 2,9,15,18 it is also uncertain whether IL-6 in saliva would change depending on the various treatment phases. If the concentrations of IL-6 in saliva change during the treatment phase, we have to be concerned about appropriate time to collect saliva samples.…”

Section: Introductionmentioning

confidence: 99%

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Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective: To elucidate the changes in interleukin-6 (IL-6) levels in whole saliva during the treatment phase in patients with oral squamous cell carcinoma (OSCC).Study Design: Twenty-nine consecutive inpatients with OSCC were enrolled in this study. Stimulated saliva was collected three times (just after hospitalization)[period 1], just before main treatment (surgery: 26/29 cases)[period 2] and at the time of discharge [period 3]. The mean intervals were 11±8 days between periods 1 and 2 and 30±18 days between periods 2 and 3. As controls, 19 age-matched healthy volunteers were also recruited. IL-6 concentrations were measured by a highly sensitive chemiluminescent enzyme immunoassay.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Sato¹,

Goto²,

Murata³

et al. 2010

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…It has been previously reported that IL-6 and IL-8 in the saliva specifically increase in oral cancer patients [17]. In addition, comprehensive proteomics analysis of changes in protein expression in the whole saliva indicated that some proteins specifically appeared or are deleted in oral cancer [18].…”

Section: Oral Cancer Screening Using Salivary Proteinsmentioning

confidence: 99%

Molecular biological change in oral cancer, summary of our researches

Yamamoto

Onda

Sugahara

et al. 2015

Japanese Dental Science Review

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The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers

Roi

Negruţiu

et al. 2020

JCM

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Fast, economic, and noninvasive, molecular analysis of saliva has the potential to become a diagnostic tool of reference for several local and systemic diseases, oral cancer included. The diagnosis of Oral Squamous Cell Carcinoma (OSCC) can be performed using high specificity and sensibility biomarkers that can be encountered in the biological fluids. Recent advances in salivary proteomics have underlined the potential use of salivary biomarkers as early diagnosis screening tools for oral neoplasia. In this respect, over 100 salivary molecules have been described and proposed as oral cancer biomarkers, out of which cytokines are among the most promising. Besides being directly involved in inflammation and immune response, the role of salivary cytokines in tumor growth and progression linked them to the incidence of oral malignant lesions. This review summarizes the existing studies based on the use of salivary cytokines as potential oral cancer biomarkers, their involvement in the malignant process based on their type, and ther influence upon prognostic and metastatic rates.

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Comparison of Cytokine in Saliva From Oral Cancer Patients and Normal Person

Cited by 4 publications

References 6 publications

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Changes in saliva interleukin-6 levels in patients with oral squamous cell carcinoma

Molecular biological change in oral cancer, summary of our researches

The Challenges of OSCC Diagnosis: Salivary Cytokines as Potential Biomarkers

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