Comparison of CT and CMR for detection and quantification of carotid artery calcification: the Rotterdam Study

Mujaj, Blerim; Lorza, Andres M. Arias; Engelen, Arna van; Bruijne, Marleen de; Franco, Oscar H.; Lugt, Aad van der; Vernooij, Meike W.; Bos, Daniël

doi:10.1186/s12968-017-0340-z

Cited by 14 publications

(11 citation statements)

References 25 publications

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“…The protocol included four sequences in axial plane: a proton density weighted (PDw)-fast spin echo (FSE)-black blood (BB) sequence (in-plane resolution 130/160 × 130/128 = 0.8 × 1 cm); a PDw-FSE-BB with an increased in-plane resolution (in-plane resolution 130/224 × 130/160 = 0.5 × 0.8 cm); a PDw-echo planar imaging (EPI) sequence (in-plane resolution 130/160 × 70/160 = 0.8 × 0.4 cm); a T2-weighted-EPI sequence (in-plane resolution 130/160 × 70/160 = 0.8 × 0.4 cm) and two three-dimensional (3D) sequences: a 3D-T1-weighted (T1w)-gradient echo sequence (in-plane resolution 180/192 × 180/180 = 0.9 × 1 cm), and a 3 D phased-contrast magnetic resonance angiography (3D-PC-MRA) (in-plane resolution 180/256 × 180/128 = 0.7 × 1.4 cm). 16 More details of the scanning protocol, reading procedure, and reproducibility are described in detail elsewhere. 17 The images of the carotid were evaluated for the presence of three different plaque components: IPH, lipid core, and calcification.…”

Section: Methodsmentioning

confidence: 99%

“…Calcification was defined as the presence of a hypointense region in the plaque on all sequences. 16 , 18 , 19 Intraplaque haemorrhage was defined as the presence of a hyperintense region in the atherosclerotic plaque on 3D-T1w-GRE. 20 , 21 Lipid core presence was defined as a hypointense region, not classified as IPH or calcification, in the plaque on PDw-FSE or PDw-EPI and T2w-EPI images or a region of relative signal intensity drop in the T2w-EPI images compared with the PDw-EPI images.…”

Section: Methodsmentioning

confidence: 99%

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Antithrombotic treatment is associated with intraplaque haemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study

Mujaj

Bos

Muka

et al. 2018

European Heart Journal

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AimsAntithrombotic treatment plays a key role in stroke prevention, but their direct effects on the composition of carotid artery atherosclerotic plaques are unknown. To investigate the association of antithrombotic treatment with carotid artery plaque composition, with a specific focus on an intraplaque haemorrhage (IPH).Methods and resultsFrom the population-based Rotterdam Study, 1740 participants with carotid atherosclerosis on ultrasound (mean age 72.9 years, 46.0 women) underwent magnetic resonance imaging of the carotid arteries to assess plaque composition. Information on the use of oral anticoagulants [vitamin K antagonists (VKA)] and antiplatelet agents (salicylates), including duration of use and dosage, was obtained from pharmacy records for all participants. We used logistic regression models to assess the association between the use of anticoagulants and antiplatelet agents, and the different plaque components adjusting for confounders. Current and past use of VKA [adjusted odds ratio (OR): 1.88, 95% confidence interval (CI): 0.74–4.75 and OR 1.89, 95% CI: 0.91–3.93] and antiplatelet agents (OR: 1.22, 95% CI: 0.91–1.62), and (OR: 1.23, 95% CI: 0.86–1.75) showed positive trend with a higher presence of IPH. Also, a longer duration of use was associated with a higher frequency of IPH (OR: 3.15, 95% CI: 1.23–8.05) for the use of VKA, and longer duration of the use for antiplatelet agents showed a positive trend (OR: 1.21, 95% CI: 0.88–1.67). We also found that higher levels of international normalized ratio above 2.97 for VKA (OR: 1.48, 95% CI: 1.03–2.15) and higher daily defined dosage than 1.0 for antiplatelet agents (OR: 1.50, 95% CI: 1.21–1.87) were related to a higher frequency of IPH. We found no association with lipid core or calcification.ConclusionsThe use of antithrombotic treatment relates to a higher frequency of IPH in carotid atherosclerotic plaques.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Antithrombotic treatment is associated with intraplaque haemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study

Mujaj

Bos

Muka

et al. 2018

European Heart Journal

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“…Lipid core presence was defined as a hypointense region, not classified as IPH or calcification, in the plaque on PDw-FSE or PDw-EPI and T2w-EPI images or a region of relative signal intensity drop in the T2w-EPI images compared with the PDw-EPI images. Calcification was defined as the presence of a hypointense region in the plaque on all sequences (14). Subjects were recorded as positive for the presence of any plaque component if the component was identified in one or both carotid arteries.…”

Section: Carotid Scanning and Analysis Of Plaque Componentsmentioning

confidence: 99%

Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study

Mujaj

Bos

Kavousi

et al. 2020

European Journal of Endocrinology

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Background To investigate the association between fasting serum insulin and glucose levels with atherosclerotic plaque composition in the carotid artery. Impaired insulin and glucose levels are implicated in the etiology of cardiovascular disease; however, their influence on the formation and composition of atherosclerotic plaque remains unclear. Methods In 1740 participants (mean age 72.9 years, 46% women, 14.4% diabetes mellitus) from the population-based Rotterdam Study, we performed carotid MRI to evaluate the presence of calcification, lipid core, and intraplaque hemorrhage in carotid atherosclerosis. All participants also underwent blood sampling to obtain information on serum insulin and glucose levels. Using logistic regression models, we assessed the association of serum insulin and glucose levels (per s.d. and in tertiles) with the different plaque components, while adjusting for sex, age, intima-media thickness, and cardiovascular risk factors. Results Serum insulin levels were associated with the presence of intraplaque hemorrhage (adjusted odds ratio (OR): 1.42 (95% CI: 1.12–1.7)) We found no association with the presence of calcification or lipid core. Sensitivity analyses restricted to individuals without diabetes mellitus yielded similar results. No associations were found between serum glucose levels and any of the plaque components. Conclusions Serum insulin levels are associated with the presence of vulnerable components of carotid plaque, specifically with intraplaque hemorrhage. These findings suggest a complex role for serum insulin in the pathophysiology of carotid atherosclerosis and in plaque vulnerability.

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“…Moreover, Mujaj et al87 compared CT‐ and cardiac magnetic resonance–based volumes of carotid artery calcification and established that they were highly correlated with each other. However, cardiac magnetic resonance–based calcification is systematically smaller than those obtained by CT.…”

Section: Multimodality Imaging Techniquesmentioning

confidence: 99%

Imaging Cardiovascular Calcification

Wang

Osborne

Tung

et al. 2018

JAHA

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Comparison of CT and CMR for detection and quantification of carotid artery calcification: the Rotterdam Study

Cited by 14 publications

References 25 publications

Antithrombotic treatment is associated with intraplaque haemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study

Antithrombotic treatment is associated with intraplaque haemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study

Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study

Imaging Cardiovascular Calcification

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