Comparison of coronary risk factors and angiographic findings in younger and older patients with significant coronary artery disease

Mahjoob, Mohammad Parsa; Sadeghi, Sajjad; Khanaman, Hamide Falahaty; Naderian, Mohammadreza; Khaheshi, Isa

doi:10.1515/rjim-2017-0048

Cited by 9 publications

(8 citation statements)

References 21 publications

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“…Furthermore, positive correlations between IL-6 and markers of atherosclerosis were mainly observed in patients older than ours. Carotid IMC thickness positively correlates with advancing atherosclerotic lesions in coronary arteries [49] that are usually less extensive in young patients than older ones [50]. However, we demonstrated the negative correlation of IL-6 level with diameter of ascending aorta.…”

Section: Discussionmentioning

confidence: 48%

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

et al. 2019

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Background: Over the last two decades, many studies have investigated the association between interleukin 6 (IL-6) and pathogenesis and progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are a particularly interesting group. They differ from older patients, not only in terms of the severity of coronary artery atherosclerosis, but also risk factor profiles, short- and long-term prognosis after myocardial infarction (MI). The role of IL-6 in younger patients with CAD is less well-known. Therefore, our study aimed to analyze the relationship between IL-6 level and other inflammations, atherosclerosis, and cardiac function parameters in early onset CAD patients. Methods: The study covered 100 patients with early onset CAD and a group of 50 healthy participants. Plasma levels of IL-6 and basic biochemical parameters, anthropometric, echocardiographic, and arteries Doppler ultrasound measurements were performed. Results: We did not observe a significant difference in IL-6 concentration in plasma between patients with early onset CAD and a control group, but IL-6 level was negatively correlated with echocardiographic measurements of ascending aorta diameter, left ventricular shortening fraction, and right ventricular end-diastolic diameter in our patients. Conclusions: In patients with early onset CAD, plasma IL-6 level is associated with other inflammation parameters and with cardiac function, potentially contributing to right ventricular remodeling and left ventricular systolic dysfunction. This suggests possible prognostic benefits of long-time observation of IL-6 level after the acute coronary syndrome.

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Section: Discussionmentioning

confidence: 48%

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

et al. 2019

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“…The mechanisms of MI in young individuals seem to differ significantly from those affecting older patients and could be grouped into three main categories: 1) atherosclerotic coronary artery disease; 2) non-atherosclerotic ischaemic heart disease; 3) hypercoagulable state. The individual's genetic profile contributes, together with other predisposing factors, to create a favorable milieu for the development of atherosclerosis and MI at a younger age 11 (Figure 1). This review article discusses the main differences that exist between the younger and elderly MI patients in the four different categories mentioned above.…”

Section: Cad Mainly Affects Older Individuals As Shown In the Landmar...mentioning

confidence: 99%

“…The left anterior descending (LAD) is the most commonly affected artery in both patient groups. Younger patients frequently present with single-vessel CAD 12,13 , fewer coronary lesions 12 and lower lesion complexity, as estimated by the Gensini score 11 which is a strong predictor of successful restoration of myocardial perfusion 14 as well as short and long-term adverse cardiovascular events 15 16 . Moreover, Gensini score was an independent predictor of long-term mortality in elderly individuals 17 .…”

Section: Coronary Plaque Featuresdifferences Between Elderly and Youn...mentioning

confidence: 99%

Risk factors profile of young and older patients with myocardial infarction

Sagris

Antonopoulos

Theofilis

et al. 2021

Cardiovascular Research

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Myocardial infarction (MI) among young adults (< 45 years) represents a considerable proportion of the total heart attack incidents. The underlying pathophysiologic characteristics, atherosclerotic plaque features and risk factors profile differ between young and older patients with MI. This review article discusses the main differences between the younger and elderly MI patients as well as the different pathogenic mechanisms underlying the development of MI in the younger. Young patients with MI often have eccentric atherosclerotic plaques with inflammatory features but fewer lesions, and are more likely to be smokers, obese, and have poor lifestyle, such as inactivity and alcohol intake. Compared to older MI patients, younger are more likely to be men, have familial-combined hyperlipidemia and increased levels of lipoprotein-a. In addition, MI in younger patients may be related to use of cannabis, cocaine use and androgenic anabolic steroids. Genomic differences especially in the pathways of coagulation and lipid metabolism have also been identified between young and older patients with MI. Better understanding of the risk factors and the anatomic and pathophysiologic processes in young adults can improve MI prevention and treatment strategies in this patient group. Awareness could help identify young subjects at increased risk and guide primary prevention strategies. Additional studies focusing on gene pathways related to lipid metabolism, inflammation and coagulation are needed.

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“…In a study by Prajapati et al 15 it was assessed that single vessel disease was more frequent in younger patients and three vessel disease was more prominent in elderly patients. Mahjoob and Yang et al 16,17 also reported in their studies that young adults are characterized by a less extensive coronary disease. Single vessel disease was common in young adults.…”

Section: A H E a D O F P R I N Tmentioning

confidence: 91%

Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center

Faisal

Habib²,

Yasmin³

et al. 2022

Pak J Med Sci

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Objective: To compare the patterns of coronary artery disease (CAD) between young adults <35 years of age and patients >35 years of age. Methods: The observational retrospective study was carried out in angiography department of emergency at Punjab Institute of Cardiology, Lahore between January 2020 and October 2020. Patients ≤35 years old were in Group-I whereas patients >35 years who served as controls were in Group-II. Patients with unstable angina, non-ST and ST elevation MI all were included. The patients with previous history of CAD (CABG/PCI) and angiography done for other purposes i.e., before valvular surgery or PPM implantation were excluded. Results: Out of 1268 patients, 552 were in Group-I and 716 were in Group-II. The prevalence of normal coronaries/ mild CAD was higher in Group-I i.e., 224(40.6%) than in Group-II i.e., 64 (8.9%). Single vessel disease (SVD) was comparable in both the groups 185 (33.5%) vs. 216 (30.2%). Double vessel disease and triple vessel disease (TVD) was common in Group-II and left main stem (LMS) involvement was also significantly higher in Group-II i.e., 32 (4.5%) vs. 8 (1.4%). Clot in coronary arteries with or without underlying CAD was seen more frequently in Group-I, 61(11.1%) vs. 34 (4.7%). Presence of clot was seen mostly in those patients who had moderate coronary artery disease. Conclusion: Young patients have different coronary artery disease patterns, so the management strategy must be different in this population. Majority of the young patients have non severe disease. Clot formation is commonly seen in young adults with moderate CAD. doi: https://doi.org/10.12669/pjms.38.8.6162 How to cite this:Faisal AWK, Habib G, Yasmin S, Latif W, Ahmed S. Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center. Pak J Med Sci. 2022;38(8):---------. doi: https://doi.org/10.12669/pjms.38.8.6162 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of coronary risk factors and angiographic findings in younger and older patients with significant coronary artery disease

Abstract: Background: Coronary artery disease (CAD) is uncommon among young adults and may

Cited by 9 publications

References 21 publications

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease

Risk factors profile of young and older patients with myocardial infarction

Angiographic patterns of coronary artery disease in young patients presenting at a tertiary cardiac center

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