Comparison Of Contrast Enhanced Color Doppler Targeted Biopsy With Conventional Systematic Biopsy: Impact On Prostate Cancer Detection

Frauscher, Ferdinand; Klauser, Andrea; Volgger, Hubert; Halpern, Ethan J.; Pallwein, Leo; Steiner, Hannes; Schuster, Antonius; Horninger, Wolfgang; Rogatsch, Hermann; Bartsch, Georg

doi:10.1016/s0022-5347(05)65171-3

Cited by 160 publications

(42 citation statements)

References 19 publications

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“…Compared with Doppler imaging employed by most previous studies (7-9, 14), the CPS harmonic imaging used in this study recognizes and processes the unique nonlinear fundamental and higher order harmonic signals generated by the contrast agent, thus allowing for a significant increase in the specificity of contrast agent-to-tissue, even at low mechanical index power levels. Furthermore, grayscale CPS imaging is less affected by motion noise and blooming artifact.…”

Section: Discussionmentioning

confidence: 99%

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Contrast-Enhanced Harmonic Ultrasonography for the Assessment of Prostate Cancer Aggressiveness: a Preliminary Study

et al. 2010

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ObjectiveTo determine whether contrast-enhanced harmonic ultrasonography can be used to predict the aggressiveness of prostate cancer.Materials and MethodsContrast-enhanced harmonic ultrasonography was performed in 103 patients suspected of prostate cancer before biopsy. Time intensity curves were reconstructed for systematic biopsy sites and sonographic abnormalities. The characteristics of the curves were described using hemodynamic indices including arrival time (AT), time-to-peak (TTP), and peak intensity (PI). The differences of hemodynamic indices between high-grade and low-grade cancer were analyzed and the correlations between the hemodynamic indices and biopsy Gleason score were studied.ResultsProstate cancer was detected in 41 of 103 patients and there were significant differences in the hemodynamic indices between the biopsy sites of the non-malignant patients and prostate cancer lesions (p < 0.05). The prostate biopsies revealed 154 prostate cancer lesions, including 31 low-grade lesions and 123 high-grade lesions. The hemodynamic indices AT and TTP of high-grade tumors were significantly shorter than those of low-grade tumors (p = 0.001, 0.002). In addition, high-grade peripheral zone (PZ) tumors had higher PI than low-grade PZ tumors (p = 0.009). The PZ prostate cancer Gleason score correlated with PI, AT and TTP, with Spearman correlation coefficients of 0.223, -0.335, and -0.351, respectively (p = 0.013, < 0.001 and < 0.001).ConclusionContrast-enhanced ultrasound measurements of hemodynamic indices correlate with the prostate cancer Gleason score.

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Section: Discussionmentioning

confidence: 99%

“…With contrast-enhanced targeted biopsy, the prostate cancer detection rate can be improved with fewer cores (7-9). Also, another study found that contrast-enhanced ultrasonography was more sensitive in detecting higher grade tumors (10) and the author suggested that contrast-enhanced ultrasound might be helpful in grading the prostate cancer.…”

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confidence: 99%

Contrast-Enhanced Harmonic Ultrasonography for the Assessment of Prostate Cancer Aggressiveness: a Preliminary Study

et al. 2010

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“…One of the most important findings is that with CEUS the number of biopsies can be greatly reduced [20, 21] with a comparable cancer detection rate. Quantification techniques are now developed and introduced that have the potential to increase the accuracy of CEUS analysis and decrease the user dependency.…”

Section: Discussionmentioning

confidence: 99%

“…Of 230 patients, PCa was detected in 69 patients (30%), with CB in 56 patients (24.4%), and with SB in 52 patients (22.6%). They concluded that the same detection rate can be obtained with less biopsies when CECD-guided biopsies are used [20]. In 2005, Pelzer et al performed a combined approach of CB and SB to investigate the impact on PCa detection.…”

Section: Contrast-enhanced Ultrasoundmentioning

confidence: 99%

Novel contrast-enhanced ultrasound imaging in prostate cancer

et al. 2011

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PurposeThe purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing.ObjectiveAlthough grayscale transrectal ultrasound is the standard method for prostate imaging, it lacks accuracy in the detection and localization of prostate cancer. With the introduction of contrast-enhanced ultrasound (CEUS), perfusion imaging of the microvascularization became available. By this, cancer-induced neovascularisation can be visualized with the potential to improve ultrasound imaging for prostate cancer detection and localization significantly. For example, several studies have shown that CEUS-guided biopsies have the same or higher PCa detection rate compared with systematic biopsies with less biopsies needed.Materials and methodsThis paper describes the current status of CEUS and discusses novel quantification techniques that can improve the accuracy even further. Furthermore, quantification might decrease the user-dependency, opening the door to use in the routine clinical environment. A new generation of targeted microbubbles is now under pre-clinical testing and showed avidly binding to VEGFR-2, a receptor up-regulated in prostate cancer due to angiogenesis. The first publications regarding a targeted microbubble ready for human use will be discussed.ConclusionUltrasound-assisted drug delivery gives rise to a whole new set of therapeutic options, also for prostate cancer. A major breakthrough in the future can be expected from the clinical use of targeted microbubbles for drug delivery for prostate cancer diagnosis as well as treatment.

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“…[ 18 ] compared colour Doppler contrast-enhanced US targeted biopsy (CB) of the prostate using Levovist (Schering, Germany) with grey-scale ultrasound-guided systematic biopsy (SB). Two hundred and thirty male screening volunteers were included.…”

Section: Prostate Cancermentioning

confidence: 99%

Ultrasound of the prostate

et al. 2010

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Ultrasound is a widely used imaging modality for evaluation of the prostate. The main topic of diagnostic imaging is an improvement of prostate cancer diagnosis. The current available systematic prostate biopsy is performed only under ultrasound guidance, but new imaging techniques allow prostate cancer visualization and therefore improved detection. Evolving methods such as contrast-enhanced colour Doppler imaging, contrast-specific ultrasound techniques and elastography may dramatically change the role of ultrasound for prostate cancer diagnosis. The purpose of this review is to provide an overview of ultrasound and its different techniques for imaging of the prostate and to discuss current trends and future directions.

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Comparison Of Contrast Enhanced Color Doppler Targeted Biopsy With Conventional Systematic Biopsy: Impact On Prostate Cancer Detection

Cited by 160 publications

References 19 publications

Contrast-Enhanced Harmonic Ultrasonography for the Assessment of Prostate Cancer Aggressiveness: a Preliminary Study

Contrast-Enhanced Harmonic Ultrasonography for the Assessment of Prostate Cancer Aggressiveness: a Preliminary Study

Novel contrast-enhanced ultrasound imaging in prostate cancer

Ultrasound of the prostate

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