Comparison of Collagen Granule Dressing Versus Conventional Dressing in Patients With Diabetic Foot Ulcer

Abstract

Background. Diabetic foot ulcer (DFU) is a difficult, chronic wound with a significant long-term influence on the morbidity, mortality, and quality of life of patients. There is much information about the biochemical features of collagen and its function in wound healing. The aim of this study was to compare the results of DFU patients treated with and without collagen. Methods. A retrospective evaluation was made of the data of patients with DFU who underwent collagen treatment and physiological serum (PS) treatment. The patients were followed-up for a minimum of 12 weeks, and all complications, healing process, and wound characteristics were recorded. Results. Of the total 64 DFU patients included in the study, 30 were treated with PS and 34 with collagen. Complete closure was achieved in 17 (56.6%) of the PS group patients after 12 weeks of treatment. The rate was 25 (73.5%) in the collagen group. The mean duration of treatment was 9.2 weeks (range = 6-12 weeks) in the PS group and 8.08 weeks (range = 5-12 weeks) in the collagen group. The recovery time and recovery rates were determined to be better in the collagen group than in the PS group. Conclusion. A significant reduction in wound size was seen in the collagen group compared with the PS group. The results of this study demonstrated that collagen dressings are better than conventional dressings with regard to early granulation tissue and shorter hospital stay.

Novel polycaprolactone (PCL)‐type I collagen core‐shell electrospun nanofibers for wound healing applications

“…Some previous works have reported the collagen electrospinning process. These works described the use of toxic, organic solvents, such as 1,1,1,3,3,3‐hexafluoro‐2‐propanol (HFIP), and recently, the use of the acetic acid aqueous solution, a green solvent 31–33 . However, the maintenance of the natural triple helical structure that forms collagen fibrils makes the electrospinning process a challenge for tissue engineering 34 .…”

“…These works described the use of toxic, organic solvents, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), and recently, the use of the acetic acid aqueous solution, a green solvent. [31][32][33] However, the maintenance of the natural triple helical structure that forms collagen fibrils makes the electrospinning process a challenge for tissue engineering. 34 This structure, which is characteristic of type I collagen, showed degradation during electrospinning process that is attributed to the solvents.…”

Autumn’s Golden Leaves

“…In Nigeria, Anumah et al 10 have demonstrated that education is an inexpensive and effective approach towards prevention of lower-limb amputations. Colak et al 11 have compared collagen granule dressings with conventional dressings in patients with DFUs, showing the benefits of the former. In 3 UK centres, Lim et al 12 have looked at the real-world experience with VACOped boot for DFUs management.…”

The Efficiency of the Natural Collagen Coating in the Treatment of Extensive Chronic Defects of the Skin and Surrounding Tissues in Dogs

“…But the healing was better with the rapid start of granulation tissue formation and wound closure in wounds of less than six months' duration treated with collagen dressings. In addition, patients with collagen covering experienced a reduction in pain and a reduction in bacterial colonization in the wound.The results of the study by C o l a k et al[6] demonstrated that collagen dressings are better than conventional dressings with regard to early granulation tissue and shorter hospital stay. The aim of this study was to compare the results of diabetic foot ulcer patients treated with and without collagen.…”