Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study

Studer, Franziska R.; Grätz, Klaus W.; Mutzbauer, Till S.

doi:10.1007/s10006-012-0319-8

Cited by 17 publications

(20 citation statements)

References 12 publications

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“…In two 2012 studies, authors compared the clinical effects of oral midazolam and oral clonidine. Studer et al .…”

Section: Discussionmentioning

confidence: 77%

“…In two 2012 studies, [11][12] authors compared the clinical effects of oral midazolam and oral clonidine. Studer et al 12 compared the anxiolytic and side effects of clonidine 150 mcg (0.150 mg) to midazolam 7.5 mg for premedication in surgical wisdom tooth extraction in 10 adults. This study was a prospective, randomized, double-blind cross-over trial with the patients undergoing bilateral wisdom tooth extractions.…”

Section: L O N I D I N E a S A P R E O P E R A T I V E S E D A T I V Ementioning

confidence: 99%

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Clonidine as a preoperative sedative

Henry

Raybould

Romond³

et al. 2018

Special Care in Dentistry

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The purpose of this study was to -examine the use of oral clonidine as a preoperative sedative prior to parenteral moderate sedation. Initially, four patients were given 0.2 mg oral clonidine but reduced to 0.1 mg clonidine due to -significant drops in blood pressure. Oral clonidine doses of 0.1 mg were then given to 19 patients preoperatively. In all these patients, blood pressure measurements decreased, but there were no significant differences in amounts of sedative agents needed in the clonidine group and the control group (N = 80). The conclusions reached suggest that clonidine has an advantage over other preoperative sedation agents in anxious patients exhibiting hypertension and tachycardia. However, the preop ideal dose required to reduce the amount of sedative drugs used as well as provide anxiolysis remains unknown. In further studies, different doses should be explored to determine what dosage of clonidine may offer hemodynamic protection as well as decrease sedative drugs needed.

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“…In two 2012 studies, authors compared the clinical effects of oral midazolam and oral clonidine. Studer et al .…”

Section: Discussionmentioning

confidence: 77%

Section: L O N I D I N E a S A P R E O P E R A T I V E S E D A T I V Ementioning

confidence: 99%

Clonidine as a preoperative sedative

Henry

Raybould

Romond³

et al. 2018

Special Care in Dentistry

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“…Unlike other classes of sedatives, clonidine has the unique feature of causing minimal or no respiratory depression. [17] Clonidine's analgesic effects are difficult to evaluate perioperatively, due to a lack of specific devices that can evaluate pain. However, its synergism with propofol can be shown by BIS [22,33].…”

Section: Discussionmentioning

confidence: 99%

Effect of clonidine on the target dose of propofol: bispectral index evaluation

2015

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“…2 There was no significant difference between both drugs, and patient satisfaction did not differ between groups. 24 Alprazolam A lpr a z ol a m , w hen c ompa r e d to ot her benzodiazepines, has the highest anxiolytic activity, with an onset of 1.4 hour and an elimination half-life of 10.6 hours. Its main effects are the reduction of anxiety and panic attacks in patients, thus being a possible alternative premedication for surgical patients.…”

Section: Literature Review Benzodiazepinesmentioning

confidence: 99%

Sedation with oral benzodiazepines in dental practice in cardiac patients

et al. 2019

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| There are different types of sedation used for performing medical and dental procedures. The medications most commonly used for this purpose are benzodiazepines, which are considered safe and effective in the hospital or outpatient dental practice. However, in dental clinical practice, they are underutilized, especially in patients with cardiovascular disease. The aim of this study was to address the use of benzodiazepines as oral sedatives, their indications, contraindications, and peculiarities, as well as their correlation with cardiac patients, through a literature review. Sedation or minimum anxiolysis is a drug-induced state during which patients respond normally to verbal commands and airway reflexes, while respiratory and cardiovascular functions are unaffected. The beneficial effects of benzodiazepines include reduced anxiety, sleep induction and maintenance, muscle relaxation, and treatment and prevention of epileptic seizures. Benzodiazepines are indicated for patients with anxiety but should be used with caution in patients with serious illnesses, pregnancy or using other central nervous system depressants. Its use in cardiac patients is safe and effective because it reduces the hemodynamic function. It is important for the dentist to know and use this class of medications, improving the quality of care for the cardiac patient. KEYWORDS | Benzodiazepines; Heart Disease; Dentistry.RESUMO | Sedação com benzodiazepínicos orais na prática odontológica em pacientes cardíacos: uma revisão de literatura • Existem diferentes tipos de sedação utilizados para a realização de procedimentos médicos e odontológicos. As medicações mais comumente usadas para este fim são os benzodiazepínicos, considerados seguros e efetivos na prática odontológica hospitalar ou ambulatorial. No entanto, na prática clínica odontológica, eles são subutilizados, especialmente em pacientes com doenças cardiovasculares. O objetivo deste estudo foi abordar o uso de benzodiazepínicos como sedativos orais, suas indicações, contraindicações e peculiaridades, bem como sua correlação com pacientes cardíacos, através de uma revisão da literatura. Sedação, ou ansiólise mínima, é um estado induzido por medicamentos, durante o qual os pacientes respondem normalmente a comandos verbais e reflexos das vias aéreas, enquanto a função respiratória e cardiovascular não é afetada. Os efeitos benéficos de benzodiazepínicos incluem redução da ansiedade, indução e manutenção do sono, relaxamento muscular e tratamento e prevenção de convulsões epiléticas. Benzodiazepínicos são indicados para pacientes com ansiedade, mas devem ser usados com cautela em pacientes com doenças graves, gravidez ou que utilizem outros depressores do sistema nervoso central. É importante que o dentista conheça e use esta classe de medicamentos, melhorando a qualidade de atendimento para o paciente cardíaco.

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Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study

Abstract: Oral administration of clonidine 150 μg and midazolam 7.5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia.

Cited by 17 publications

References 12 publications

Clonidine as a preoperative sedative

Clonidine as a preoperative sedative

Effect of clonidine on the target dose of propofol: bispectral index evaluation

Sedation with oral benzodiazepines in dental practice in cardiac patients

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