Comparison of Clinical-Pathologic Characteristics and Outcomes of True Interval and Screen-Detected Invasive Breast Cancer Among Participants of a Canadian Breast Screening Program: A Nested Case-Control Study

Rayson, Daniel; Payne, Jennifer; Abdolell, Mohamed; Barnes, Penny J.; MacIntosh, Rebecca F.; Foley, T.; Younis, Tallal; Burns, Ariel; Caines, Judy

doi:10.3816/cbc.2011.n.005

Cited by 43 publications

(39 citation statements)

References 30 publications

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“…Less favourable size, grading and biomarker expression were found in interval cancers compared to screen-detected cancers [7,43,44]. The higher frequency of triple negative interval cancers compared with the screen-detected cancers was also identified in other studies, conveying a more aggressive behaviour and adverse prognosis to these tumours [43,44].…”

Section: Discussionmentioning

confidence: 74%

Performance indicators evaluation of the population-based breast cancer screening programme in Northern Portugal using the European Guidelines

Bento

Gonçalves

Aguiar

et al. 2015

Cancer Epidemiology

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Section: Discussionmentioning

confidence: 74%

Performance indicators evaluation of the population-based breast cancer screening programme in Northern Portugal using the European Guidelines

Bento

Gonçalves

Aguiar

et al. 2015

Cancer Epidemiology

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“…While screening rates are often lower in low SES populations, this does not wholly account for the high grade nature of the tumors seen in these populations. High grade, locally advanced tumors are more likely to present between screenings as interval cancers [72]. While this is a relatively small study, it provides characterization of serial patients seen at a public safety-net hospital, who have a strikingly high proportion of cases with elevated PCNA ?…”

Section: Discussionmentioning

confidence: 97%

Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity

Mukhtar

Moore

Nseyo

et al. 2011

Breast Cancer Res Treat

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African American and Hispanic women develop more triple negative breast cancer at younger ages than Caucasian women. The frequently observed association between race and socioeconomic status (SES) has confounded our understanding of the outcomes disparities seen in these groups. Given the association between inflammatory cells and high-grade, triple negative tumors, we sought to investigate whether differences in the presence of these cells varies by race. We evaluated breast tumor specimens for the presence PCNA+ tumor-associated macrophages (TAMs) in consecutive cases from a county hospital serving primarily un- or under-insured patients. All patients in this cohort had elevated PCNA + TAM levels. Higher PCNA + TAM counts were associated with hormone receptor (HR) negative tumors and non-Caucasian ethnicity. Hispanic women specifically had significantly higher PCNA + TAM counts than Caucasian patients and shorter disease-free survival. These findings implicate immune function in the development of aggressive breast cancer and suggest a possible link between SES and the inflammatory response.

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“…True interval cancers show increased tumor cell proliferation (6,(10)(11)(12) and lower expression of both estrogen receptors (ER) and progesterone receptors (PR; 6, 9, 12, 13) than screen-detected cancers. Some recent studies have found an enrichment of triple negative phenotype among true interval cancers (9,14,15). Lately, genetic and epigenetic mechanisms have been related to interval cancers, such as the methylation process of specific genes (16) or the action of growth factors produced in the breast stroma in response to tumoral aggressiveness (17).…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling in True Interval Breast Cancer Reveals Overactivation of the mTOR Signaling Pathway

Rojo

Domingo

Sala

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The development and progression of true interval breast cancers (tumors that truly appear after a negative screening mammogram) is known to be different from screen-detected cancers. However, the worse clinical behavior of true interval cancers is not fully understood from a biologic basis. We described the differential patterns of gene expression through microarray analysis in true interval and screen-detected cancers.Methods: An unsupervised exploratory gene expression profile analysis was performed on 10 samples (true interval cancers ¼ 5; screen-detected cancers ¼ 5) using Affymetrix Human Gene 1.0ST arrays and interpreted by Ingenuity Pathway Analysis. Differential expression of selected genes was confirmed in a validation series of 91 tumors (n ¼ 12; n ¼ 79) by immunohistochemistry and in 24 tumors (n ¼ 8; n ¼ 16) by reverse transcription quantitative PCR (RT-qPCR), in true interval and screen-detected cancers, respectively.Results: Exploratory gene expression analysis identified 1,060 differentially expressed genes (unadjusted P < 0.05) between study groups. On the basis of biologic implications, four genes were further validated: ceruloplasmin (CP) and ribosomal protein S6 kinase, 70 kDa, polypeptide 2 (RPS6KB2), both upregulated in true interval cancers; and phosphatase and tensin homolog (PTEN) and transforming growth factor beta receptor III (TGFBR3), downregulated in true interval cancers. Their differential expression was confirmed by RT-qPCR and immunohistochemistry, consistent with mTOR pathway overexpression in true interval cancers.Conclusions: True interval and screen-detected cancers show differential expression profile both at gene and protein levels. The mTOR signaling is significantly upregulated in true interval cancers, suggesting this pathway may mediate their aggressiveness.Impact: Linking epidemiologic factors and mTOR activation may be the basis for future personalized screening strategies in women at risk of true interval cancers. Cancer Epidemiol Biomarkers Prev; 23(2); 288-99. Ó2013 AACR.

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Comparison of Clinical-Pathologic Characteristics and Outcomes of True Interval and Screen-Detected Invasive Breast Cancer Among Participants of a Canadian Breast Screening Program: A Nested Case-Control Study

Cited by 43 publications

References 30 publications

Performance indicators evaluation of the population-based breast cancer screening programme in Northern Portugal using the European Guidelines

Performance indicators evaluation of the population-based breast cancer screening programme in Northern Portugal using the European Guidelines

Elevated PCNA+ tumor-associated macrophages in breast cancer are associated with early recurrence and non-Caucasian ethnicity

Gene Expression Profiling in True Interval Breast Cancer Reveals Overactivation of the mTOR Signaling Pathway

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