Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel

Griffiths, Gareth; Smart, G. J.; Bulman, J S; Weiss, Gina; Shrowder, J.; Newman, H. N.

doi:10.1034/j.1600-051x.2000.027012910.x

Cited by 70 publications

(54 citation statements)

References 23 publications

(37 reference statements)

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“…The results are superior to commercially available products (e.g., ELYZOL®, a MET containing gel) that need to be applied with greater drug concentrations over a 7-day period [39,40]. Finally, for the antibacterial experiments we chose the periodontal pathogen Porphyromonas gingivalis [42], one of the major virulent pathogens associated with periodontal disease and some device-associated infections such as peri-implantitis [43,44].…”

Section: Discussionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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Article:Gentile, P., Frongia, M.E., Redon, M.C. et al. (4 more authors) (2015) Functionalised nanoscale coatings using Layer-by-Layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces. Acta Biomaterialia.https://doi.org/10.1016/j.actbio.2015.04.009 eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractIn order to achieve high local biological activity and reduce the risk of side effects of antibiotics in the treatment of periodontal and bone infections, a localised and temporally controlled delivery system is desirable. The aim of this research was to develop a functionalised and resorbable surface to contact soft tissues to improve the antibacterial behaviour during the first week after its implantation in the treatment of periodontal and bone infections. Solvent-cast poly(D,L-lactide-coglycolide acid) (PLGA) films were aminolysed and then modified by Layer-by-Layer technique to obtain a nano-layered coating using poly(sodium4-styrenesulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) as polyelectrolytes. The water-soluble antibiotic, metronidazole (MET), was incorporated from the ninth layer. Infrared spectroscopy showed that the PSS and PAH absorption bands increased with the layer number. The contact angle values had a regular alternate behaviour from the ninth layer. X-Ray Photoelectron Spectroscopy evidenced two distinct peaks, N 1s and S 2p , indicating PAH and PSS had been introduced. Atomic Force Microscopy showed the presence of polyelectrolytes on the surface with a measured roughness about 10 nm after 20 layers deposition.The drug release was monitored by Ultraviolet-visible spectroscopy showing 80% loaded-drug delivery in 14 days. Finally, the biocompatibility was evaluated in vitro with L929 mouse fibroblasts and the antibacterial properties were demonstrated successfully against the keystone periodontal bacteria Porphyromonas gingivalis, which has an influence on implant failure, without compromising in vitro biocompatibility. In this study, PLGA was successfully modified to obtain a localised and temporally controlled drug delivery system, demonstrating the potential value of LbL as a coating technology for the manufacture of me...

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Section: Discussionmentioning

confidence: 99%

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

et al. 2015

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“…As an example, a commercially available gel may be cited containing 25% of metronidazole, which could release the drug for no more than 36 hours. 16 While some studies with this gel demonstrated improvements in clinical and microbiological parameters of periodontitis after subgingival application as a monotherapy 24 or when associated with conventional mechanical therapy, [25][26][27] others did not observe such advantages in the use of this association. [28][29][30] Studies to assess the effects of this gel on clinical and microbiological parameters of periodontitis are currently being conducted and the results will complement the evaluation of this thermoreversible gel as a local delivery system for periodontitis treatment.…”

Section: Discussionmentioning

confidence: 99%

Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

Sato¹,

Fonseca²,

Ciampo

et al. 2008

Braz. oral res.

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The aim of this investigation was to monitor metronidazole concentrations in the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs after treatment with an experimental 15% metronidazole gel. Five dogs had periodontitis induced by cotton ligatures placed subgingivally and maintained for a 30-day period. After the induction period, only pockets with 4 mm or deeper received the gel. Each pocket was filled up to the gingival margin by means of a syringe with a blunt-end needle. GCF was collected in paper strips and quantified in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel administration. The GCF samples were assayed for metronidazole content by means of a high performance liquid chromatography method. Concentrations of metronidazole in the GCF of the 5 dogs (mean ± SD, in µg/mL) were 0 ± 0 before gel application and 47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ± 23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single administration of the 15% metronidazole gel released the drug in the GCF of dogs in levels several-fold higher than the minimum inhibitory concentration for some periodontopathogens grown in subgingival biofilms for up to one hour, but metronidazole could be detected in the GCF at least 48 hours after the gel application.

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“…Regarding adjunctive local (SRPloc) therapy, irrigation of the pockets with disinfectants, application of local drug delivering devices [17][18][19][20][21][22] or local laser treatment [23][24][25][26] were identified. Pocket irrigation and mouth rinses in most of the studies were performed with chlorhexidine [27][28][29]66].…”

Section: Resultsmentioning

confidence: 99%

Improving Scaling And Root Planing Over The Past 40 Years: A Meta-Analysis

M¹

2014

Dentistry

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Aim: To screen whether or not classical non-surgical periodontal therapy improved over the last four decades and how adjunctive local or systemic measures influenced its clinical outcome. Methodology:Starting from the year 1970, the entire annual sets of publications of every 5th year of the "Journal of Clinical Periodontology" and the "Journal of Periodontology" were hand searched for articles dealing with nonsurgical periodontal therapy, i.e. scaling and root planing either alone (SRP) or in combination with adjunctive local (SRPloc) or systemic (SRPsyst) treatment. Mean pocket reduction was computed for each of the three treatment modalities. Where applicable, a meta-analysis and a meta-regression as well as linear regression were performed.Results: A total of 52 articles were found. Twenty-six thereof were randomized clinical trials. The meta-analysis revealed a standardized mean difference of pocket reduction of 0.77 mm (95% CI=0.283; 1.255) and 0.90 mm (95% CI 0.210; 1.593 for SRPloc-SRP and SRPsyst-SRP, respectively (P<0.0001). Meta regression showed significantly more mean pocket reduction for SRPloc (p=0.011) and SRPsyst (p=0.001) than for SRP. In addition, a negative correlation between time to re-evaluation and mean pocket reduction could be found (p=0.015). None of the treatment modalities improved over the past 40 years. Conclusion:Adjunctive local or systemic measures seem to improve the classic non-surgical periodontitis therapy, i.e. scaling and root planing. None of the three analyzed treatment modalities improved over the past 40 years.

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Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel

Cited by 70 publications

References 23 publications

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Functionalised nanoscale coatings using layer-by-layer assembly for imparting antibacterial properties to polylactide-co-glycolide surfaces

Metronidazole-containing gel for the treatment of periodontitis: an in vivo evaluation

Improving Scaling And Root Planing Over The Past 40 Years: A Meta-Analysis

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