Comparison of clinical features and laboratory findings of coronavirus disease 2019 and influenza A and B infections in children: a single-center study

Siddiqui, Meraj Alam; Gultekingil, Ayse; Bakırcı, Oğuz; Uslu, Nihal; Baskın, Esra

doi:10.3345/cep.2021.00066

Cited by 10 publications

(18 citation statements)

References 26 publications

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“…Comparing these symptomatic infections, we found that pediatric disease presentation is very similar between endemic HCoVs and SARS-CoV-2, with each frequently presenting with “common cold” symptoms. Consistent with other studies, we found differences in symptom presentation by age; this may be, perhaps, because older children have had more endemic HCoV exposures [ 2 , 4 , 6 , 17 , 22 ]. We also found great variability in symptom duration for SARS-CoV-2 and endemic HCoV infections; symptoms from endemic HCoV and SARS-CoV-2 infections lasted anywhere from 1 day to more than 28 [ 20 ].…”

Section: Discussionsupporting

confidence: 91%

“…Differences in immune response between adults and children likely provide children better protection against severe SARS-CoV-2 infections [ 3 – 5 ]. Previous research found no differences in severity between SARS-CoV-2 infections and influenza A and B among children [ 6 , 7 ]. However, it is unknown if, in children, SARS-CoV-2 infections are distinct in disease presentation and severity from endemic human coronavirus (HCoV) infections.…”

Section: Introductionmentioning

confidence: 93%

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SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

Frutos

Kubale

Kuan

et al. 2022

PLOS Glob Public Health

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It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are distinct in symptom presentation, duration, and severity from endemic coronavirus infections in children. We compared symptom risk and duration of endemic human coronavirus (HCoV) infections from 2011–2016 with SARS-CoV-2 infections from March 2020-September 2021 in a Nicaraguan pediatric cohort. Blood samples were collected from study participants annually in February-April. Respiratory samples were collected from participants that met testing criteria. Blood samples collected in were tested for SARS-CoV-2 antibodies and a subset of 2011–2016 blood samples from four-year-old children were tested for endemic HCoV antibodies. Respiratory samples were tested for each of the endemic HCoVs from 2011–2016 and for SARS-CoV-2 from 2020–2021 via rt-PCR. By April 2021, 854 (49%) cohort participants were ELISA positive for SARS-CoV-2 antibodies. Most participants had antibodies against one alpha and one beta coronavirus by age four. We observed 595 symptomatic endemic HCoV infections from 2011–2016 and 121 symptomatic with SARS-CoV-2 infections from March 2020-September 2021. Symptom presentation of SARS-CoV-2 infection and endemic coronavirus infections were very similar, and SARS-CoV-2 symptomatic infections were as or less severe on average than endemic HCoV infections. This suggests that, for children, SARS-CoV-2 may be just another endemic coronavirus. However, questions about the impact of variants and the long-term effects of SARS-CoV-2 remain.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 93%

SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

Frutos

Kubale

Kuan

et al. 2022

PLOS Glob Public Health

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“…Siddiqui et al statistically confirmed that symptoms such as fever, cough, rhinorrhea, vomiting, and abdominal pain were greater in children with Influenza than in those with COVID-19. 21 Also, in this study, diarrhea was more frequent (but non-statistically significant) in the Influenza group than in the one with COVID-19, while headache was a symptom more frequently reported by children with COVID-19. 21 …”

Section: Resultscontrasting

confidence: 52%

“…A comparison of clinical features between COVID-19 and Influenza was reported in 11 of 12 studies. 10 – 17 , 19 – 21 …”

Section: Resultsmentioning

confidence: 99%

Comparison of the Clinical and Laboratory Features of Covid and Influenza in Children

Pata¹,

Buonsenso²,

Valentini³

2022

Mediterr J Hematol Infect Dis

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Background and Objectives. Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has a clinical presentation ranging from asymptomatic course to flu-like syndrome up to respiratory failure. Seasonal Influenza, due by the influenza viruses and very common in children, can cause symptoms similar to COVID-19. In order to identify clinical and laboratory characteristics that allow health-care workers to differentiate COVID-19 from Influenza, we performed a systematic review of the existing literature in the pediatric age. Methods. The research was done via PubMed for articles published from March 2020 to October 2021, combining the MeSH words "COVID-19" and "Influenza" and "Children" and considering the suggestions of PRISMA Group. Results. The most frequently described symptoms were fever and cough in both groups. In most studies, high fever, cough, nasal congestion or rhinorrhea, vomiting and muscle pain were detected more frequently in the Influenza group. Regarding the value of laboratory tests, the results were mixed. Almost all studies reported significantly lower levels of C-reactive protein and procalcitonin in the COVID-19 group than in the Influenza group. In most manuscripts, COVID-19 had a milder course than Influenza. Conclusions. There are no symptoms characteristic of a single infectious agent, with flu-like disorders being the most common. In addition, laboratory tests do not help in the differential diagnosis but show a limited inflammatory response in COVID-19. This could explain the fewer complications compared to adulthood, with a less severe clinical course. Keywords: COVID-19; Influenza; children

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“…(3–5) Previous research found no differences in severity between SARS-CoV-2 infections and influenza A and B among children. (6, 7) However, it is unknown if, in children, SARS-CoV-2 infections are distinct in disease presentation and severity from endemic human coronavirus (HCoV) infections.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

Frutos

Kubale

Kuan

et al. 2021

Preprint

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It has been proposed that as SARS-CoV-2 transitions to endemicity, children will represent the greatest proportion of SARS-Co-V-2 infections as they currently do with endemic coronavirus infections. While SARS-CoV-2 infection severity is low for children, it is unclear if SARS-CoV-2 infections are distinct in symptom presentation, duration, and severity from endemic coronavirus infections in children. We compared symptom risk and duration of endemic coronavirus infections from 2011-2016 with SARS-CoV-2 infections from March 2020-September 2021 in a Nicaraguan pediatric cohort. Respiratory samples were collected from participants that met testing criteria and blood samples were collected annually. Respiratory samples were tested for each of the endemic coronaviruses from 2011-2016 and for SARS-CoV-2 from 2020-2021 via rt-PCR. 2021 blood samples were tested for SARS-CoV-2 antibodies and a subset of 2011-2016 blood samples from four-years-old participants were tested for endemic coronavirus antibodies. By April 2021, 854 (49%) active participants were ELISA positive for SARS-CoV-2 antibodies. Most participants had antibodies against one alpha and one beta coronavirus by age four. We observed 595 symptomatic endemic coronavirus infections from 2011-2016 and 121 symptomatic with SARS-CoV-2 infections from March 2020-September 2021. Symptom presentation of SARS-CoV-2 infection and endemic coronavirus infections were very similar, and SARS-CoV-2 symptomatic infections were as or less severe on average than endemic coronavirus infections. This suggests that, for children, SARS-CoV-2 may be just another endemic coronavirus. However, questions about the impact of variants and the long-term effects of SARS-CoV-2 remain.

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Comparison of clinical features and laboratory findings of coronavirus disease 2019 and influenza A and B infections in children: a single-center study

Abstract: Comparison of clinical features and laboratory findings of coronavirus disease 2019 and influenza A and B infections in children: a single-center studyRunning title: Clinical and laboratory findings of pediatric COVID-19 versus influenza patients

Cited by 10 publications

References 26 publications

SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

Comparison of the Clinical and Laboratory Features of Covid and Influenza in Children

SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children

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