Comparison of clinical characteristics of patients with follicular thyroid carcinoma and Hürthle cell carcinoma

Selenium, selenoproteins and cancer of the thyroid

“…Conversely, in the follicular form, haematogenous metastases are more frequent, mainly affecting the lungs and bones [14]. Hurthle cell carcinoma is follicular in origin, with at least 75% of the cells being Hurthle cells and having capsular and/or vascular invasion [16]. The Hurthle cell is characterized cytologically as a large cell with abundant eosinophilic, granular cytoplasm, and a large hyperchromatic nucleus with a prominent nucleolus.…”

“…Hurthle cell carcinoma is poorly avid to radioiodine and poorly responsive to chemotherapy and radiation [18]. Hurthle cell carcinoma is believed to be more aggressive than common follicular carcinoma [16].…”