Approach the Invasive Potential with Hurthle Cell Tumors of Thyroid

Ding, Li; Jiang, Yunhui; Wan, Yang

doi:10.1007/s12253-018-0546-x

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…The above findings indicate that solitary nodules consisting of oncocytes may actually represent adenomas, regardless of the absence of the established criteria to diagnose an adenoma. Taking into account that the morphology of oncocytes is basically the same in hyperplastic nodules and in adenomas, we tried to investigate immunohistochemically if there is any difference in the expression of previously used proteins in oncocytic neoplasms, such as b-catenin [9], Cyclin D1, p53, and Ki67 [10], without any significant result. Immunohistochemical staining for p53 showed positivity in all cases.…”

Section: Casementioning

confidence: 99%

Oncocytic Hyperplastic Nodule Versus Oncocytic Adenoma: Diagnostic Controversies Through a Brief Investigative Case Series Study

Topalidis,

Petrakis,

Koletsa

2024

Cureus

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Oncocytes are frequently encountered in routine thyroidectomies. The distinction between oncocytic hyperplastic nodules and oncocytic adenomas (OAs) may be challenging. Although both entities are benign, a precise diagnosis is essential. We present two cases of solitary oncocytic lesions carrying pathogenic mutations in the p53 and NRAS genes, respectively, leading to a histological diagnosis of oncocytic hyperplastic nodules. Additionally, similar oncocytic nodules from two cases of autoimmune thyroiditis did not show any significant findings on molecular analysis (next-generation sequencing, NGS). Hence, this brief investigative series study is of particular diagnostic interest because it prompts pathologists to use the term adenoma when a solitary oncocytic nodule is encountered, regardless of the established criteria for the diagnosis of adenoma. This viewpoint leads to the possible need for the reevaluation of the histological criteria of adenomas when it comes to oncocytic lesions in order to gain a common diagnostic approach and nomenclature among pathologists and overcome any controversies in such cases.

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Section: Casementioning

confidence: 99%

Oncocytic Hyperplastic Nodule Versus Oncocytic Adenoma: Diagnostic Controversies Through a Brief Investigative Case Series Study

Topalidis,

Petrakis,

Koletsa

2024

Cureus

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“…Thyroglobulin may show perinuclear positivity. According to the literature, genes associated with Retinoid-interferon-induced Mortality-19 (GRIM-19) [60], p53 [56], and Cyclin D [61,62] can be immunohistochemically detected.…”

Section: Histological Features and Differential Diagnosis At Histologymentioning

confidence: 99%

Thyroid Hürthle Cell Carcinoma: Clinical, Pathological, and Molecular Features

Kure

Ohashi

2020

Cancers

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Hürthle cell carcinoma (HCC) represents 3–4% of thyroid carcinoma cases. It is considered to be more aggressive than non-oncocytic thyroid carcinomas. However, due to its rarity, the pathological characteristics and biological behavior of HCC remain to be elucidated. The Hürthle cell is characterized cytologically as a large cell with abundant eosinophilic, granular cytoplasm, and a large hyperchromatic nucleus with a prominent nucleolus. Cytoplasmic granularity is due to the presence of numerous mitochondria. These mitochondria display packed stacking cristae and are arranged in the center. HCC is more often observed in females in their 50–60s. Preoperative diagnosis is challenging, but indicators of malignancy are male, older age, tumor size > 4 cm, a solid nodule with an irregular border, or the presence of psammoma calcifications according to ultrasound. Thyroid lobectomy alone is sufficient treatment for small, unifocal, intrathyroidal carcinomas, or clinically detectable cervical nodal metastases, but total thyroidectomy is recommended for tumors larger than 4 cm. The effectiveness of radioactive iodine is still debated. Molecular changes involve cellular signaling pathways and mitochondria-related DNA. Current knowledge of Hürthle cell carcinoma, including clinical, pathological, and molecular features, with the aim of improving clinical management, is reviewed.

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