Comparison of Clinical Characteristics and Comorbidity in Schizophrenia Patients With and Without Obsessive-Compulsive Disorder

Poyurovsky, Michael; Kriss, Victoria; Weisman, Gregory; Faragian, Sarit; Kurs, Rena; Schneidman, Michael; Fuchs, Camil; Weizman, Abraham; Weizman, Ronit

doi:10.4088/jcp.v64n1104

Cited by 65 publications

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“…Differences in the rates of compulsive disorder 13,14,23,25,26 , phobic anxiety disorder 8 and panic disorder 11,23 reported elsewhere and rates revealed in this study may be due to methodological differences.…”

contrasting

confidence: 58%

“…Reports about the effects of co-morbid anxiety disorder on function have varied with some studies reporting greater functional impairment 5 while others found no significant difference between the two comparison groups 13 . Rosen and Jahreiss in 1946 concluded that the presence of obsessive compulsive symptoms conferred some protection against cognitive deficits, functional impairment, and negative symptoms associated with schizophrenia 14 .…”

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confidence: 99%

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Co-morbid anxiety disorders in patients with schizophrenia in a tertiary institution in South East Nigeria: prevalence and correlates.

Aguocha

Uwakwe

et al. 2015

Afr H. Sci.

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Background: Anxiety disorders occur commonly in schizophrenia but are often overlooked by psychiatrists. Their presence may compound the challenges faced by these patients and may contribute to poor outcome. Objectives: The purpose of this study was to determine the prevalence of anxiety disorders among the participants with schizophrenia, and the association between this co-morbidity and disability. Method: A total of 367 participants were recruited from the out-patient department of Federal neuropsychiatric hospital Enugu, Nigeria. Socio-demographic questionnaire, schedules for clinical assessment in neuropsychiatry, positive and negative syndrome scale and the 12-item version of the World Health Organization disability assessment schedule were administered. Results: A total of 189 females (51.5%) and 178 (48.5%) males were studied. A lifetime prevalence of 12.3% was reported for anxiety disorder. Anxiety disorder was more likely in females (κ²=4.93, p<0.03). Specific prevalence for anxiety disorder in schizophrenia was generalized anxiety disorder 6.3%, obsessive compulsive disorder 3.3%, and phobic anxiety disorder 2.7%. Anxiety disorder was associated with increased disability (t=3.50, p<0.001) and psychopathology (t=3.40, p<0.001) among the participants studied. Phobias were associated with prescription of low doses of antipsychotics (κ²=4.08, p<0.04). There was a low rate of identification of anxiety disorder in routine clinical practice (k=0.08, p<0.001). Conclusion: Co-morbid anxiety disorders are common in schizophrenia and they are associated with increased disability and psychopathology. The results emphasize the need to screen for anxiety disorders in patients with schizophrenia.

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confidence: 58%

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confidence: 99%

Co-morbid anxiety disorders in patients with schizophrenia in a tertiary institution in South East Nigeria: prevalence and correlates.

Aguocha

Uwakwe

et al. 2015

Afr H. Sci.

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“…schizo-obsessives who have a genetic liability for both schizophrenia and OCD (Poyurovsky et al 2003(Poyurovsky et al , 2004Kayahan et al 2005) ; that treatment with atypical antipsychotics (such as clozapine) may unmask OCD previously hidden by schizophrenic symptoms (Ertugrul & Demir 2005) ; or that some, as yet unidentified, factor may predispose individuals both to OCD and to schizophrenia. Thus, greater levels of illness co-morbidity might be predicted in such patients.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of OCD in the general population remains quite controversial ; however, it is certainly much lower (with estimates from 0.08 to 2.5 % ; e.g. Fireman et al 2001 ;Crino et al 2005) than the prevalence of OCD in schizophrenia, which has estimates ranging from 0.5 to 59.2 % both in firstepisode and in chronic schizophrenia (Bland et al 1987 ;Karno et al 1988 ;Berman et al 1995 ;Eisen et al 1997 ;Poyurovsky et al 1999aPoyurovsky et al , 2000Poyurovsky et al , 2003Poyurovsky et al , 2006Bermanzohn et al 2000 ;Kruger et al 2000 ;Niehaus et al 2005 ;Mukhopadhaya et al 2009) and for OCS in schizophrenia the estimated prevalence is similarly between 3.5 and 46 % (Rosen, 1957 ;Myers et al 1984 ;Fenton & McGlashan, 1986 ;Berman et al 1995Berman et al , 1998Lysaker et al 2000 ;Tibbo et al 2000 ;Fabisch et al 2001). It remains unclear if this reflects a true comorbidity, more severe illness or perhaps a unique diagnostic subcategory of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

et al. 2009

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Background. Interest in the neuro-cognitive profile of patients with schizophrenia and co-morbid obsessive compulsive disorder (schizo-OCD) is rising in response to reports of high co-morbidity rates. Whereas schizophrenia has been associated with global impairment in a wide range of neuro-cognitive domains, OCD is associated with specific deficits featuring impaired performance on tasks of motor and cognitive inhibition involving frontostriatal neurocircuitry.Method. We compared cognitive function using the CANTAB battery in patients with schizo-OCD (n=12) and a schizophrenia group without OCD symptoms (n=16). The groups were matched for IQ, gender, age, medication, and duration of illness.Results. The schizo-OCD patients made significantly more errors on a task of attentional set-shifting (ID-ED set-shift task). By contrast, no significant differences emerged on the Stockings of Cambridge task, the Cambridge Gamble Task or the Affective Go/NoGo tasks. No correlation emerged between ID-ED performance and severity of schizophrenia, OCD or depressive symptoms, consistent with neurocognitive impairment holding trait rather than statemarker status. Schizo-obsessives also exhibited a trend toward more motor tics emphasizing a neurological contribution to the disorder. Conclusion.Our findings reveal a more severe attentional set-shifting deficit and neurological abnormality that may be fundamental to the neuro-cognitive profile of schizo-OCD. The clinical implications of these impairments merit further exploration in larger studies.

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“…[23,49] OKB'si olan şizofreni hastalarının şizofreni belirtilerinin şiddeti, daha fazla OKB spektrum bozukluğu görülmesi ve daha fazla klozapin ve SSRI kullanı-mı açısından farklılıklar gösterdiği vurgulanmaktadır. [50] Son dönemde Şi-zofreni ve OKB için DSM-IV tanı ölçütlerini karşılayan ergen hastalarla yapı-lan bir çalışmada; şizo-obsesif hastalarda şizofreni belirtileri için erken başlan-gıç yaşı, daha fazla obsesif-kompulsif spektrum bozuklukları (başlıca tik bozuklukları) görüldüğü ancak şizofreni belirtilerinin şiddetinde bir farklılık olmadığı dikkat çekmiştir. Ayrıca, şizo-obsesif bozukluğu olan hastaların OKB'si olmayan şizofreni hastalarına göre daha sıklıkla kombine antiobsesyonel ajanlarla tedavi edildiği görülmüştür.…”

Section: Klinik öZelliklerunclassified

Schizo-obsessive Disorder

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2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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Obsessive-compulsive features are common in schizophrenia. Current genetic, neurobiological, clinical and epidemiological data about obsessive-compulsive symptoms/disorder in schizophrenia suppose that schizophrenia combined with OCD is more than a mere comorbidity. Epidemiologic and neurobiological evidence suggest that the patients with comorbid OCD and schizophrenia may present a special category among patients with schizophrenia. Although a specific profile has not been emerged yet; clinical, neurobiological research about schizo-obsessive patients have been extensively pursued.

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Comparison of Clinical Characteristics and Comorbidity in Schizophrenia Patients With and Without Obsessive-Compulsive Disorder

Cited by 65 publications

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Co-morbid anxiety disorders in patients with schizophrenia in a tertiary institution in South East Nigeria: prevalence and correlates.

Co-morbid anxiety disorders in patients with schizophrenia in a tertiary institution in South East Nigeria: prevalence and correlates.

The neuropsychology of the schizo-obsessive subtype of schizophrenia: a new analysis

Schizo-obsessive Disorder

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