J. Clin. Lab. Anal. volume 29, issue 6, P462-468 2014 DOI: 10.1002/jcla.21794 View full text
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Stacey K. Mardekian, Charalambos C. Solomides, Jerald Z. Gong, Stephen C. Peiper, Zi-Xuan Wang, Renu Bajaj

Abstract: CISH is advantageous for allowing pathologists to evaluate the histologic and molecular alterations occurring simultaneously in a specimen. Moreover, CISH is found to be more cost- and time-efficient when used with automation, and the signals do not quench over time. CISH technique is a reliable alternative to FISH in the evaluation of adipocytic tumors for MDM2 amplification.