Comparison of choroidal thickness in systemic hypertensive subjects with healthy individuals by spectral domain optical coherence tomography

Abstract

Purpose: The purpose of the study was to compare the choroidal thickness in normal population and hypertensive patients and to assess the possible effect of hypertension on choroidal thickness using Spectral Domain Optical Coherence Tomography (SD-OCT). Methods: This was a comparative cross-sectional study. A total of 68 eyes of 34 individuals in the age group of 40–60 years were included in both the hypertensive group and control group. Individuals with refractive error beyond ± 3 D and posterior segment pathology were excluded. The choroidal thickness was measured at the sub-foveal region, 500 μm nasal and 500 μm temporal to the fovea on SD-OCT with enhanced depth imaging (EDI) mode. Systolic blood pressure (SBP), Diastolic blood pressure (DBP), and Mean arterial pressure (MAP) were recorded in all individuals. Duration of hypertension was also noted in hypertensive individuals. Results: The choroidal thickness at all locations was significantly lower in the hypertensive group (subfoveal, nasal, temporal and mean choroidal thickness 253.24 ± 63.96 μm, 249.35 ± 63.57 μm, 250.01 ± 63.37 μm, 250.87 ± 63.38 μm, respectively) as compared to the control group (subfoveal, nasal, temporal and mean choroidal thickness 301.25 ± 55.79 μm, 298.97 ± 57.07 μm, 299.49 ± 55.06 μm, 299.90 ± 55.50 μm, respectively). The choroidal thickness in the hypertensive group also had a significant negative correlation with the SBP (Spearman correlation coefficient, rho = –0.35, P = 0.003) and the duration of hypertension (rho = -0.25, P = 0.037). Conclusion: The study demonstrated decreased choroidal thickness in systemic hypertensive subjects as compared to age-matched healthy individuals. The choroidal thickness in hypertensive subjects also had a significant but weak negative correlation with SBP and duration of hypertension.

The Diagnostic Value of Multispectral Fundus Imaging in Hypertensive Retinopathy

“…This study analyzed the difference in CVI between HR patients and normal people by MSI and found that the CVI of patients with HR was lower than that of the normal control group. The cross-sectional study by Waghamare et al 19 demonstrated that choroidal thickness was significantly lower in the hypertensive group compared with the control group. The choroidal thickness of the hypertensive group was significantly negatively correlated with systolic blood pressure and duration of hypertension.…”

“…This study analyzed the difference in CVI between HR patients and normal people by MSI and found that the CVI of patients with HR was lower than that of the normal control group. The cross-sectional study by Waghamare et al 19 demonstrated that choroidal thickness was significantly lower in the hypertensive group The detection sensitivity, specificity, positive prediction value, and negative prediction value of MSI were compared with FFA. Short wavelengths (550, 600, and 620 nm) were used to calculate the detection sensitivity and specificity for different lesions of HR.…”

Retinal and Choroidal Thinning—A Predictor of Coronary Artery Occlusion?

“…Waghamare and others carried out a study where choroidal thickness was measured and compared in healthy controls and patients with one of the main CVD factors—hypertension. They found that choroidal thickness at all locations was significantly lower in the hypertensive group, and it had a significant negative correlation with the systolic blood pressure and the duration of hypertension [ 44 ]. The average choroidal thickness of our participants is like Chinese healthy contemporaries’ in a study carried out by Ding and others.…”