Comparison of chlorthalidone, a long-acting antihypertensive and diuretic agent, with chlorothiazide

Kakaviatos, Nikos; Finnerty, Frank A.

doi:10.1016/0002-9149(62)90384-3

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…49,59,60 In a study published in 1962, mean arterial pressure was reduced from 148 mm Hg at baseline to 128 mm Hg with chlorthalidone 50 mg daily and to 122 mm Hg with 100 mg daily. 59 Tweeddale et al 61 conducted or a decrease of 10 mm Hg or more was achieved in 0% of patients on placebo, in 45% with 12.5 mg, in 35% with 25 mg, in 41% with 50 mg, and in 42% with 75 mg daily. Thus, 12.5 mg did lower BP in many patients, though not statistically differently from placebo.…”

Section: Chlorthalidonementioning

confidence: 99%

Hydrochlorothiazide Versus Chlorthalidone

2004

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Abstract-Thiazide diuretics are one of the preferred pharmacologic treatments for hypertension. Hydrochlorothiazide and chlorthalidone have been the 2 most commonly used diuretics in major clinical trials. Treatment guidelines and compendia often consider these 2 drugs interchangeable agents within the class of thiazide or thiazide-like diuretics. Many sources list them as equipotent. Despite these beliefs, there is some suggestion that cardiovascular outcomes are not necessarily the same with these 2 drugs. We conducted a literature search from 1960 to 2003 to identify studies that evaluated the pharmacokinetic and blood pressure-lowering effects of these 2 agents. There are significant pharmacokinetic and pharmacodynamic differences between these diuretics. Chlorthalidone is Ϸ1.5 to 2.0 times as potent as hydrochlorothiazide, and the former has a much longer duration of action. Whether these pharmacokinetic and pharmacodynamic features cause differences in outcomes is not known.

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Section: Chlorthalidonementioning

confidence: 99%