Comparison of chlordecone and NDL-PCB decontamination dynamics in growing male kids after cessation of oral exposure: Is there a potential to decrease the body levels of these pollutants by dietary supplementation of activated carbon or paraffin oil?

Modeling chlordecone toxicokinetics data in growing pigs using a nonlinear mixed-effects approach

“…CLD has a different behavior from other POPs such as PCB because CLD is known to be more concentrated in liver and muscle than in fat tissues (Lastel et al, 2016;Lastel et al, 2018).…”

Correlation between endemic chlordecone concentrations in three bovine tissues determined by isotopic dilution liquid chromatography–tandem mass spectrometry

“…The distribution of CLD in fat, muscle and liver has also been reported to document the contamination and/or decontamination kinetics for male Alpine kids (Lastel et al, 2018), Muscovy ducks (Jondreville et al, 2014b) and pigs (ANSES 2019). It was also documented for poultry, where liver and fat were investigated (Jondreville et al, 2014a).…”

“…Moreover, it was concluded that the maximum residue levels Concerning livestock, the target tissue for official controls is perirenal fat, since it is the tissue in which non-polar organochlorine pesticides are supposed to be mostly distributed. However, some studies have shown that CLD has atypical behaviour regarding its tissue distribution, and found that CLD is not only distributed in fat but also in muscle in certain species, such as poultry (Jondreville et al, 2014a), ducks (Jondreville et al, 2014b), growing male Alpine kids (Lastel et al, 2018), ewes Saint-Hilaire et al, 2018 and pigs (Fourcot et al, 2020). This raises the question of distribution in other species such as bovines, which are largely consumed and are one of the most targeted species for official food controls.…”

“…CLD concentrations can be determined either by gas or liquid chromatography; methods are mostly adapted from Bordet et al (Bordet et al, 2007). For gas chromatography, detection can be performed with an electron capture detector (GC/ECD) or mass spectrometry, with low or high resolution (Clostre et al, 2014;Florence et al, 2015;Fournier et al, 2017;Lastel et al, 2018;Méndez-Fernandez et al, 2018). This second type of detection is recommended in the case of positive results (i.e.…”

“…Although gas chromatography is still used, most of the current methods, including the official method for controls in France, are based on isotopic dilution followed by reversed-phase liquid chromatography analysis and tandem mass spectrometry detection with negative electrospray ionization (Clostre et al, 2015;Lastel et al, 2018;Saint-Hilaire et al, 2018). Isotopic dilution is recommended to ensure accurate identification and quantification.…”