Comparison of central corneal thickness (CCT) and intraocular pressure (IOP) in patients with pseudoexfoliation and healthy individuals without pseudoexfoliation

Abstract

BACKgRound:The aim of a study was to compare the central corneal thickness (CCT) and intraocular pressure (IOP) in patients with pseudoexfoliation (PXF) and age-matched healthy individuals without PXF. MATeRiAl And MeThodS: This prospective comparative study was conducted at the Medical College Hospital in South India. The study was conducted on 100 patients who were divided into two groups. Patients with PXF were categorized as group 1 (50 patients) and healthy normal individuals without PXF as group 2 (50 patients). Visual acuity was recorded using Snellen's visual acuity chart. Anterior segment examination was done using a slit lamp. Central corneal thickness was measured using ultrasonic pachymetry. Intraocular pressure was measured using Goldmann applanation tonometer and corrected intraocular pressure (IOP) after pachymetry. ReSulTS:In group 1 mean age of patients was 64.76 ± 5.5 years. 18 (32%) were females, 32 (64%) were males. In group 2 mean age was 61.56 ± 5.1 years, with 29 (58%) males and 21 (42%) females. Central corneal thickness was significantly thinner in patients with PXF than in controls. The mean CCT in the PXF group was 536 ± 24 microns and the control group 561 ± 25 microns with a p-value of 0.03, which was statistically significant. Mean corrected IOP in the PXF group was 16.698 ± 6.70 mm Hg, and in the control group was 13.66 ± 2.14 mm Hg with p-value 0.00, which was statistically significant. ConCluSion:The study shows that corneas are thinner in patients with PXF as compared to controls. Hence CCT should be done in all the PXF patients, and the corrected IOP should be measured to prevent the false low estimation of IOP.