Comparison of CCL28, interleukin‐8, interleukin‐1β and tumor necrosis factor‐alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis

Abstract

CCL28, IL-8, IL-1β and TNF-α may play key roles in the host response to inflammation in periodontal diseases. As the severity of periodontal diseases increases, destruction of periodontal tissues also increases. Inflammation is one among many factors that trigger periodontal tissue destruction. Identification of the mediators that influence the development and progression of inflammation in periodontal diseases may be very important in understanding the prognoses of periodontal diseases.

Effects of curcumin on crevicular levels of IL‐1β and CCL28 in experimental gingivitis

“…20 The chemokine (C-C motif) ligand 28 (CCL28) is a novel marker for the diagnosis of gingivitis and periodontitis. 21 Previous studies have shown CCL28 is associated with increased epithelial inflammation. [22][23][24] The production of IL-1b increases following contact with a microbial stimulus, which in turn significantly increases the expression of CCL28.…”

“…[22][23][24] The production of IL-1b increases following contact with a microbial stimulus, which in turn significantly increases the expression of CCL28. 21 To our knowledge, there are no studies evaluating the effectiveness of curcumin as a topical chemotherapeutic agent for periodontal disease. Curcumin has a combined anti-inflammatory, antioxidant and antibacterial effect.…”

Análise clínica e de citocinas no fluido gengival de pacientes com periodontite agressiva - estudo longitudinal

“…Os níveis de ICAM-1, IL-1β, 1L-17, M-CSF e TNF-α estavam mais elevados nos pacientes com PA do que nos pacientes saudáveis, com diferenças estatisticamente significantes, resultados semelhantes a outros estudos (Duarte et al, 2010;Shaddox et al, 2007;Ertugrul et al, 2013;Cifcibasi et al, 2015), Apenas a IL-10 foi estatisticamente maior no grupo saudável, como esperado, já que é uma citocina anti-inflamatória.…”

“…Procurando comparar os níveis da quimiocina epitelial associada à mucosa (CCL28), da IL-8, da IL-1β e do TNF-α, Ertugrul et al (2013) analisaram o fluido gengival de pacientes portadores de PAG, pacientes com PC, pacientes com gengivite e sujeitos periodontalmente saudáveis, e observaram que esse biomarcador estava em concentrações mais elevadas nos indivíduos com PAG, quando comparados com PC, gengivite e saudáveis.…”

Neutrophils alter epithelial response to Porphyromonas gingivalis in a gingival crevice model.

“…Concentrations of IL-8 and IL-1β in gingival crevicular fluid are known to correlate with periodontal disease severity (Ertugrul et al, 2012). Multiple oral bacteria, in both planktonic and biofilm form, are known to induce IL-1β and IL-8, and other proinflammatory cytokines, from human oral epithelial cells (Peyyala et al, 2012).…”