Comparison of catalytic activities between esterase and lipase in the synthesis of drugs and flavor and amide compounds

Abstract

The synthesis of drugs, drug intermediates, and flavor and amide compounds by PLE (pig liver esterase) and PPL (pig pancreatic lipase) carried out in this laboratory has been reviewed and their selectivity in the synthesis of compounds compared. A new method of synthesis of paracetamol, a common analgesic drug, using PLE and PPL to overcome the complicated steps for chemical synthesis starting from p-aminophenol, which is an unstable compound, has been discussed. A new route for enzymatic transesterification of geraniol has been efficiently carried out by PLE, and the result was better than PPL.

Green synthesis and catalytic application of curcumin stabilized silver nanoparticles

“…Furthermore, this reaction results in the removal of nitrophenols, which are regarded as one of the most widespread environmental pollutants, while nitro to amino conversion process is of high industrial relevance such as for production of aniline, paracetamol, etc. 15 It is worthwhile to mention here that there are only a few reports in literature on reduction of Nip over AgNPs but with little or no kinetic studies. 16,17 In the present study, therefore, the first step was the preparation of c-AgNPs by an ultrasound assisted synthesis protocol.…”

“…16,17 In the present study, therefore, the first step was the preparation of c-AgNPs by an ultrasound assisted synthesis protocol. We explored ultrasound assisted or sonochemical reduction route for this synthesis to overcome the general disadvantage of longer reaction time, 15 generally associated with such green synthesis. In the sonochemical technique acoustic cavitation due to high intensity ultrasonic irradiation of water leads to formation of highly reactive H• and OH• radicals.…”

Kinetics of p-Nitrophenol Reduction Catalyzed by PVP Stabilized Copper Nanoparticles

“…[10]. It is also an important intermediate in synthesis protocols of several drugs [11]. Reduction of NP can be carried out by either metal/acid reduction or by catalytic hydrogenation.…”

Production of p-acetaminophenol by whole-cell catalysis using Escherichia coli overexpressing bacterial aryl acylamidase

“…One-step reductive amidation of nitroarenes is another path for chemical synthesis of p-AAP (Bhattacharya et al 2006). Production of p-AAP was achieved with pig liver esterase and N,O-diacetyl-p-aminophenol as substrate (Patil et al 2009). Once p-AP from chemical synthesis is directly used as a reactant for the biocatalytic process, it can be advantageous in that these two processes can be carried out in a continuous mode.…”