Comparison of casein phosphopeptide-amorphous calcium phosphate and fluoride gel in remineralization of demineralized human enamel surfaces

Abstract

Background: Remineralization is the natural repair process for carious lesions. We have knowledge about remineralization for a hundred years. However, it is only in recent decades that the therapeutic importance of remineralization has been generally accepted. But when the bacterial challenge is high or the salivary components are lacking, remineralization is insufficient to halt or reverse the caries process. So, there is a need to find ways to enhance the remineralization process and to transfer such knowledge into clinical therapy.

The effect of casein phosphopeptide-amorphous calcium phosphate paste and sodium fluoride mouthwash on the prevention of dentine erosion: An in vitro study

“…[ 7 ] Taleb et al ., compared CPP-ACP and fluoride gel in remineralization of demineralized human enamel surfaces. [ 18 ] Some other studies assessed the effect of CPP-ACP on prevention of erosive enamel and dentin wear and demineralization. [ 17 19 20 ]…”

Biomimetic Remineralization of Early Human Enamel Carious Lesions With Different Commercially Available Herbal Nanohydroxyapatite Toothpastes: An in-Vitro Comparative Evaluation

“…The taste, smell, post-brushing feeling, and foaming qualities of toothpastes contribute to the enjoyable experience of brushing teeth and help people maintain this practice. In the current experiment, nanohydroxyapatite was chosen as a biomimetic material as its deposition of calcium/phosphate minerals in enamel resembles hydroxyapatite, how ever, the crystalline deposition of minerals mimics the natural one by filling the micropores on demineralized enamel 37 . In addition, herbal-based toothpastes showed significant reduction in plaque levels and improving salivary pH without any side effects or using animal products [38][39][40] .…”

Biomimetic Remineralization with Nano-Hydroxyapatite Treatment of Enamel Erosion (an in vitro study)

“…In the current study, nano-hydroxyapatite was directly selected as a biomimetic remineralizing agent as its deposition of calcium / phosphate minerals in enamel resembling the hydroxyapatite, however, the crystalline deposition of minerals mimic the natural one and due to filling the micropores on demineralized enamel (8) . Nano-hydroxyapatite particles were regularly deposited on the demineralized enamel surface.…”

“…Nano-hydroxyapatite has a similar morphology to crystal apatite of enamel and added to toothpastes, mouthwashes (7) . Therefore, the efficacy of prevention of enamel erosion depends on the actual precipitation of hydroxyapatite structure like enamel required for the remineralization process (8) .…”