Comparison of Carotid Arterial Resistive Indices With Intima-Media Thickness as Sonographic Markers of Atherosclerosis

Frauchiger, Beat; Schmid, Hans Peter; Roedel, Christian; Moosmann, Peter; Staub, Daniel

doi:10.1161/01.str.32.4.836

Cited by 105 publications

(115 citation statements)

References 37 publications

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“…22,25 Furthermore, when the resistive index is measured in the internal carotid artery, it shows a high correlation with increased IMT and with the severity of atherosclerosis as well as the ability to distinguish between low-and high-risk patients. 26 A direct correlation between IMT, LVMI and the risk of myocardial infarction and stroke in a population of patients without a prior history of CV disease has been shown. [27][28] We report that the highest RRI levels are associated with other forms of CV organ damage.…”

Section: Discussionmentioning

confidence: 97%

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

et al. 2007

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We evaluated the relationship between renal resistive index (RRI) of the intrarenal vasculature and cardiovascular (CV) organ damage such as left ventricular hypertrophy (LVH), diastolic dysfunction and carotid atherosclerosis in a large sample of hypertensive patients. 566 hypertensive patients underwent echocardiography with conventional Doppler and Doppler tissue imaging (DTI), carotid and renal ultrasonography. In addition, lipids profile, creatinine in serum, and urinary albumin concentrations were determined. The patients were divided according to their RRI values in 2 groups: o70 and X70. Subjects with high RRI were older, had higher systolic and pulse pressure (PP) and more years of hypertension, compared to those with low RRI (Po0.0001). Patients with the higher RRI showed an increased left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) with a higher prevalence of LVH, carotid plaques and microalbuminuria (Po0.001). There were differences in overall diastolic parameters, in particular when evaluated by DTI (Po0.001). A positive correlation was found between RRI and age, PP, carotid IMT, LVMI, SBP and a negative correlation was found with DTI diastolic parameters (Po0.001). Age, PP, carotid IMT and LVMI were independently related to RRI. While, RRI was independently related to IMT and IVRT. RRI, especially the higher values, are positively correlated with target organ damage in hypertensive patients, indicating that renal vascular resistance is related to morphologic and hemodynamic alteration of the CV system. The evaluation of RRI could predict the presence of early CV damage and provide an accurate estimate of overall risk.

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Section: Discussionmentioning

confidence: 97%

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

et al. 2007

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“…20 In the present study, we evaluated the relationship between serum proinflammatory markers and atherosclerosis as estimated by IMT and carotid haemodynamics in patients with essential hypertension.…”

Section: Introductionmentioning

confidence: 99%

Association between carotid haemodynamics and inflammation in patients with essential hypertension

et al. 2005

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Previous studies have shown that high blood pressure causes chronic inflammation. Hypertensive patients are reported to have high-circulating levels of proinflammatory cytokines such as interleukin-6 (IL-6) and high sensitive C-reactive protein (hs-CRP). The pulsatility index (PI) and resistive index (RI) are used as markers of peripheral vascular resistance. In the present study, we evaluated the relationship between carotid haemodynamics and the proinflammatory cytokines, IL-6 and hs-CRP. In all, 41 patients with essential hypertension participated. The intima-media thickness (IMT), peak systolic velocity (pVs), peak diastolic velocity (pVd) and mean velocity (mV) in the common carotid artery were measured using ultrasound Doppler flow methods, and PI [(pVsÀpVd)/mV] and RI [(pVsÀpVd)/pVs] were calculated. Serum IL-6 and hs-CRP concentrations were measured by an enzyme-linked immunosorbent assay. IMT was positively correlated with age and pulse pressure. Both PI and RI were positively correlated with pulse pressure, IL-6 and hs-CRP. A multiple regression analysis revealed that PI and RI were independently associated with hs-CRP. These results suggested that carotid haemodynamic parameters such as PI and RI are associated with atherosclerosis and inflammation in hypertensive patients.

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“…L'integrazione con il color-Doppler consente di ottenere informazioni sulle caratteristiche del flusso locale, di quantificare il grado di eventuali stenosi, nonché di valutare l'integrità del circolo distale al sito di campionamento. Tra i parametri ecografici morfologici di aterogenesi precoce, lo spessore medio-intimale (IMT, intimamedia thickness) dell'arteria carotide comune (ACC) e dell'arteria carotide interna (ACI), non solo riflette le alterazioni parietali locali, ma costituisce un segno di aterosclerosi generalizzata (14)(15)(16). Analogamente, il processo aterosclerotico generalizzato è risultato correlato con il grado di distensibilità parietale, con lo spessore parietale totale e con gli indici flussimetrici, in particolare con l'indice di resistenza (IR) (14).…”

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“…Tra i parametri ecografici morfologici di aterogenesi precoce, lo spessore medio-intimale (IMT, intimamedia thickness) dell'arteria carotide comune (ACC) e dell'arteria carotide interna (ACI), non solo riflette le alterazioni parietali locali, ma costituisce un segno di aterosclerosi generalizzata (14)(15)(16). Analogamente, il processo aterosclerotico generalizzato è risultato correlato con il grado di distensibilità parietale, con lo spessore parietale totale e con gli indici flussimetrici, in particolare con l'indice di resistenza (IR) (14). L'IMT corrisponde allo spessore dell'intima e della media, i quali sono formati da endotelio, tessuto connettivo e fibre muscolari.…”

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Atherosclerosis in rheumatoid arthtritis: the role of high-resolution B mode ultrasound in the measurement of the arterial intima-media thickness

Carotti¹,

Salaffi²,

Mangiacotti³

et al. 2011

Reumatismo

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carico delle piccole e delle grandi articolazioni diartrodali, ad impronta destruente, spesso associata con la positività del fattore reumatoide. La prevalenza dell'AR è nell'ordine dello 0,5% (1, 2), con netta predilezione per il sesso femminile (rapporto uomini/donne di 1:3) in età fertile. L'AR presenta un'espressività clinica polimorfa, in rapporto alla topografia, al grado di evoluzione dell'impegno articolare ed alla possibile presenza di manifestazioni extraarticolari. Tra queste, il coinvolgimento dell'apparato cardiovascolare, ed in particolare la cardiopatia ischemica (CI), rappresenta, per la severità prognostica, una INTRODUZIONE L'artrite reumatoide (AR) è una malattia infiammatoria sistemica, caratterizzata da un processo di sinovite cronica prevalentemente a Reumatismo, 2007; 59(1)

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Comparison of Carotid Arterial Resistive Indices With Intima-Media Thickness as Sonographic Markers of Atherosclerosis

Cited by 105 publications

References 37 publications

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

Renal resistive index and cardiovascular organ damage in a large population of hypertensive patients

Association between carotid haemodynamics and inflammation in patients with essential hypertension

Atherosclerosis in rheumatoid arthtritis: the role of high-resolution B mode ultrasound in the measurement of the arterial intima-media thickness

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