Association between carotid haemodynamics and inflammation in patients with essential hypertension

Manabe, Seiko; Okura, Takafumi; Watanabe, Sachiko; Higaki, Jitsuo

doi:10.1038/sj.jhh.1001898

Cited by 43 publications

(35 citation statements)

References 33 publications

(34 reference statements)

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“…However, impaired endothelial function in conduit vessels may reflect increased arterial stiffness that can influence cardiac afterload (21), and recent evidence suggests a direct correlation between impaired carotid artery hemodynamics and hypertension in humans (22). Nonetheless, it will be important to examine vascular function in smaller resistance-type arteries.…”

Section: Discussionmentioning

confidence: 99%

Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus

Ryan¹,

McLemore²

2007

American Journal of Physiology-Regulatory, Integrative and Comp

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August 3, 2006; doi:10.1152/ajpregu.00168.2006.-Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that predominantly affects women during their reproductive years. Although women with SLE have hypertension, the underlying mechanisms for this have not been examined. Despite the fact that inflammation is associated with altered endothelial and vascular function, the role of altered vascular function in the development of hypertension during SLE is unclear. In the present study, we tested whether a mouse model of SLE (NZBWF1) develops hypertension and examined whether increased blood pressure was associated with impaired endothelial-dependent relaxation. Female NZBWF1 mice were studied at 8, 20, and 36 wk of age. By 36 wk, urinary albumin and antinuclear antibodies were increased in SLE compared with control mice. Mean arterial pressure, measured by radiotelemetry, was significantly increased in SLE mice (124 Ϯ 4 mmHg, n ϭ 10) compared with control NZW/LacJ mice (111 Ϯ 3 mmHg, n ϭ 7) at 36 wk. Isolated carotid arteries from NZBWF1 mice, precontracted with U-46619 for assessment of endothelialdependent relaxation, demonstrated a progressively impaired relaxation to ACh with age, although endothelial nitric oxide synthase mRNA expression was not different. Maximal tension generated by 5-hydroxytryptamine was increased in carotid arteries from NZBWF1 mice compared with controls at 8, 20, and 36 wk of age, suggesting a role for altered vascular function early on in the progression of SLE. Taken together, our data support a role for altered endothelial function as a contributing factor to the development of hypertension during SLE. systemic lupus erythematosus; autoimmune; hypertension; endothelial; pressure; auto-antibody SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is a complex genetic autoimmune disorder that leads to the production of antibodies against an individual's own healthy tissues. Any organ system can be affected during SLE, although individuals often present with skin rashes, joint pain, and renal problems. While no known cure for SLE exists, current immunosuppressive therapies have markedly reduced shortterm mortality rates. Long-term mortality rates, on the other hand, are increasingly influenced by cardiovascular complications. Indeed, individuals with SLE are at an alarmingly high risk for stroke, myocardial infarction, atherosclerosis, renal disease, and hypertension.Interestingly, SLE predominantly affects women (at a ratio of 9:1 women-men) during reproductive years, a period when they are typically thought to be "protected" against the development of cardiovascular disease. During this time, women with SLE are Ͼ50 times more likely to develop cardiovascular disease independent of traditional Framingham risk factors (23), with a high prevalence of hypertension, atherosclerosis, and glomerulosclerosis (1,34,38). Despite the high incidence of hypertension and peripheral vascular disease, there have been few studies directed at understanding the mechanisms of hypertension during SL...

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Section: Discussionmentioning

confidence: 99%

Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus

Ryan¹,

McLemore²

2007

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Inflammatory processes play a pivotal role in the pathogenesis of atherosclerosis (29,30 ) and hypertension (31,32 ). Recent studies indicate that micronized fenofibrate decreases the serum concentrations of cytokines and hsCRP (33 ).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Micronized Fenofibrate on Carotid Atherosclerosis in Patients with Essential Hypertension

Zhu

Meng

2006

Clinical Chemistry

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Background:The coexistence of hypertension and dyslipidemia synergistically increases the risk of cardiovascular events. We investigated the effect of the lipidlowering agent micronized fenofibrate on inhibition of carotid atherosclerosis in patients with essential hypertension and mild hyperlipidemia. Methods: We measured serum lipid profiles and inflammatory markers on chemistry or immune analyzers and common or internal carotid intima-media thickness (IMT) and diameter (D) by ultrasonography.Results: Patients receiving micronized fenofibrate for 24 months in addition to antihypertensive treatment had decreased concentrations of total cholesterol, LDLcholesterol, triglyceride, apolipoprotein B100, oxidized LDL, high-sensitivity C-reactive protein, P-selectin, and cytokines. These patients had increased concentrations of HDL-cholesterol, apolipoprotein A-I, and nitric oxide. Common carotid artery IMT (CCAIMT) and internal carotid artery IMT (ICAIMT) remained unchanged during the 24-month intervention. Moreover, the mean CCAIMT/D ratio and ICAIMT/D ratio were significantly decreased in the fenofibrate intervention group. In contrast, CCAIMT/D and ICAIMT/D ratios were increased in the control group. The incidence rates of carotid artery plaque formation and stroke in the fenofibrate intervention group were significantly lower than those in the control group.

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“…In contrast, we determined a weak but negative correlation between right IMT and right PI. As in the studies above, PI and RI should also be expected to increase parallel to IMT in hemodialysis patients with increased atherosclerosis risk, because PI and RI indices reflects vascular resistance which are related to the thickness of arterial wall [27].…”

Section: Discussionmentioning

confidence: 96%

Carotid hemodynamic parameters in hemodialysis patients

et al. 2008

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Association between carotid haemodynamics and inflammation in patients with essential hypertension

Cited by 43 publications

References 33 publications

Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus

Hypertension and impaired vascular function in a female mouse model of systemic lupus erythematosus

Inhibitory Effects of Micronized Fenofibrate on Carotid Atherosclerosis in Patients with Essential Hypertension

Carotid hemodynamic parameters in hemodialysis patients

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