Comparison of Cardiopulmonary Effects of Medetomidine–Midazolam, Acepromazine–Butorphanol and Midazolam–Butorphanol in Dogs

Kojima, Kentaro; Nishimura, Ryohei; Mutoh, Tatsushi; Takao, Kenji; Matsunaga, Satoru; Mochizuki, Manabu; Sasaki, Nobuo

doi:10.1046/j.1439-0442.1999.00224.x

Cited by 23 publications

(31 citation statements)

References 9 publications

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“…In dogs, a similar decrease in BP has been observed during the first 20 min post-injection of a butorphanol-midazolam combination (Kojima et al, 1999), with intramuscular doses of 0.2 mg/kg each decreasing SAP by 15 mmHg (Novellas et al, 2007). Since we could not measure NIBP in unsedated ferrets, it was not possible to determine whether midazolam and butorphanol affected BP at the dosages used in our study.…”

Section: Discussionsupporting

confidence: 64%

Non-invasive blood pressure measurement in ferrets ( Mustela putorius furo ) using high definition oscillometry

Zeeland

Wilde

Bosman

et al. 2017

The Veterinary Journal

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A B S T R A C TThis study was conducted to validate the use of high definition oscillometry (HDO) for non-invasive blood pressure (NIBP) measurements in ferrets and to establish reference ranges for NIBP in minimally sedated, healthy, young adult ferrets (<4 years of age). The bias, limits of agreement and correlation for HDO compared to direct arterial blood pressure (DABP) measurement were established in 14 anaesthetised ferrets. Measurements were performed at the forelimb, hind limb and tail under hypo-(<110 mmHg), normo-(110-170 mmHg) and hypertensive (>170 mmHg) conditions. Although HDO correlated well with DABP (r > 0.90), it showed significant proportional bias, whereby HDO generally underestimated DABP with hyper-and normotensive conditions, and overestimated DABP with hypotensive conditions. Measurements obtained from the hind limb showed higher bias than those obtained from the tail or forelimb (P < 0.001). Based on the above, and for practical reasons, the tail was selected as the preferred site of cuff placement in ferrets. Subsequently, a cross-over study was performed in 10 ferrets to establish the minimum dose of butorphanol and midazolam needed to successfully obtain NIBP in 100% of cases. Using this dose (0.2 mg/kg IM, each), reference intervals for NIBP from 63 healthy, young adult ferrets were established at 95-155 mmHg (systolic), 69-109 mmHg (mean) and 51-87 mmHg (diastolic) arterial pressures.

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Section: Discussionsupporting

confidence: 64%

Non-invasive blood pressure measurement in ferrets ( Mustela putorius furo ) using high definition oscillometry

Zeeland

Wilde

Bosman

et al. 2017

The Veterinary Journal

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“…The doses were determined based on previous research [5,8] and the drugs were administered 10 to 15 min before the induction of anesthesia. The specific combination of premedicants administered to each dog was chosen by the anesthetists according to the physical status of the animal.…”

mentioning

confidence: 99%

“…In the present study, bradycardia was observed in 27.5% of the MB group, 40% of the AB group and 70% of the Med group after the administration of premedicants or propofol. It has been reported that changes in heart rate after the administration of MB or AB are usually mild and that bradycardia observed in dogs premedicated with MB and AB may be induced by the additive or supra-additive effects of MB or AB and propofol [8]. It is also well known that medetomidine induces severe bradycardia in dogs [3,15].…”

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confidence: 99%

Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

Sano

Nishimura

Mochizuki

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. The effects of acepromazine-butorphanol (AB), midazolam-butorphanol (MB) and medetomidine (Med) on the induction dose of propofol and their compatibility with propofol were evaluated in client-owned dogs. All premedications induced good to excellent sedation and the induction dose of propofol was considerably reduced. Of the tested premedicants, Med induced the deepest sedation and the most potent dose-sparing effect. Induction of anesthesia was excellent to good in all dogs except for one dog premedica ted with MB. Most dogs premedicated with AB or MB showed temporary apnea. Although other adverse effects such as bradycardia or hypotension may also occur, premedication with MB, AB or Med is a valuable technique for the induction of anesthesia with propofol in dogs in a clinical setting. KEY WORDS: canine, premedication, propofol.J. Vet. Med. Sci. 65(10): 1141-1143, 2003 Propofol is an intravenous anesthetic which has highly desirable characteristics such as rapid onset of anesthesia, short duration of action, lack of accumulation upon repeated administration and lack of excitatory effects on induction [1,16]. Because of these beneficial characteristics, propofol is now accepted as a useful agent in dogs. In veterinary anesthesia, preanesthetic medications such as tranquilizers, sedatives and analgesics are commonly used for the safe and smooth induction of anesthesia. The preanesthetic use of drugs has been shown to have a sparing effect on the induction dose of intravenous anesthetics [4,10,11]. Preanesthetic medication has also been reported to modify the cardiovascular effects induced by induction agents. The purpose of this study was to evaluate the effects of acepromazine-butorphanol, midazolam-butorphanol and medetomidine on the dose of propofol needed to induce anesthesia in dogs, and to examine the compatibility of these preanesthetics with propofol in clinical cases.Eighty client-owned dogs were evaluated in this study. These patients were admitted to the Veterinary Medical Center of the University of Tokyo from April of 2000 to July of 2001 for a variety of surgeries or treatments. Their age, body weight, gender, the type of surgery or treatment and the combination of premedicants used before anesthesia are shown in Table 1, which also includes the physical status of each animal before anesthesia based on the American Society of Anesthesiologists (ASA) standards [6,12]. The heart rate (HR) and arterial blood pressure (BP) were monitored non-invasively by a multifunction monitor (Multifunction monitor COLIN BP-58 , Nihon Colin Co. , Tokyo , Japan).The following drugs were used for preanesthetic medication: intramuscular medetomidine (Med; Domitor, Meijiseika Co., Tokyo , Japan) at a dose of 1,000 µg/m 2 , intravenous midazolam (Dormicum , Yamanouchi Pharmaceutical Co., Tokyo , Japan) and butorphanol (Stadol, Bristol -Myers Squibb Co., Tokyo , Japan) (MB) at doses of 0.1 and 0.2 mg/kg, respectively, and intramuscular acepromazine (Prom Ace, Fort Dodge Laboratories Inc., Iowa , U.S.A.) and buto...

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“…Administration of preanesthetic medications is also valuable for reducing the required dose of injectable anesthetics needed for induction of anesthesia and may result in fewer adverse effects or effects of lesser severity. [8][9][10][11][12][13] In other studies 14,15 conducted by our laboratory group, sedative and cardiopulmonary effects of 3 combinations of preanesthetic medications (medetomidinemidazolam [MM], acepromazine-butorphanol [AB], and midazolam-butorphanol [MB]) were evaluated in dogs. Administration of MM induces deep sedation accompanied by analgesia and muscle relaxation and also depresses arousal reactions to external stimuli.…”

mentioning

confidence: 99%

Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs

Kojima

Nishimura

Mutoh

et al. 2002

ajvr

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Comparison of Cardiopulmonary Effects of Medetomidine–Midazolam, Acepromazine–Butorphanol and Midazolam–Butorphanol in Dogs

Cited by 23 publications

References 9 publications

Non-invasive blood pressure measurement in ferrets ( Mustela putorius furo ) using high definition oscillometry

Non-invasive blood pressure measurement in ferrets ( Mustela putorius furo ) using high definition oscillometry

Effects of Midazolam-Butorphanol, Acepromazine-Butorphanol and Medetomidine on an Induction dose of Propofol and Their Compatibility in Dogs

Effects of medetomidine-midazolam, acepromazine-butorphanol, and midazolam-butorphanol on induction dose of thiopental and propofol and on cardiopulmonary changes in dogs

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