Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats

Ersoy, Burak; Bayrami̇çli̇, Mehmet; Ercan, Feríha; Şirinoğlu, Hakan; Turan, Pınar; Numanoğlu, Ayhan

doi:10.1055/s-0034-1396770

Cited by 16 publications

(2 citation statements)

References 31 publications

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“…The current understanding of the blood supply to bone suggests that a direct periosteal (DP) or penetrating periosteal vessel (PPV) blood supply can perfuse the periosteum and adjacent outer third of cortical bone, supporting a robust vascular supply for tissue transfer with numerous potential donor sites ( Figure 5) (Sparks et al, 2017). Experimentation to date using periosteal flaps as an axial vascularization strategy has been extensive (Runyan et al, 2010;Li et al, 2012;Han et al, 2014;Ersoy et al, 2015;Nau et al, 2016), yet exclusively performed through an extrinsic approach. A recent study by Nau et al (2016) evaluated the role of a periosteal flap alone compared with a periosteal flap with a ßTCP scaffold with or without autologous bone marrow derived mononuclear cells (BMCs).…”

Section: Periosteal Flapsmentioning

confidence: 99%

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies—A Quest for Regenerative Matching Axial Vascularization

Sparks

Savi

Saifzadeh

et al. 2020

Front. Bioeng. Biotechnol.

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The prevalent challenge facing tissue engineering today is the lack of adequate vascularization to support the growth, function, and viability of tissue engineered constructs (TECs) that require blood vessel supply. The research and clinical community rely on the increasing knowledge of angiogenic and vasculogenic processes to stimulate a clinically-relevant vascular network formation within TECs. The regenerative matching axial vascularization approach presented in this manuscript incorporates the advantages of flap-based techniques for neo-vascularization yet also harnesses the in vivo bioreactor principle in a more directed "like for like" approach to further assist regeneration of the specific tissue type that is lost, such as a corticoperiosteal flap in critical sized bone defect reconstruction.

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Section: Periosteal Flapsmentioning

confidence: 99%

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies—A Quest for Regenerative Matching Axial Vascularization

Sparks

Savi

Saifzadeh

et al. 2020

Front. Bioeng. Biotechnol.

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“…The periosteum possesses active osteoprogenitor cells with osteoinductive potential that can be further enhanced when combined with bioactive scaffolds. Materials such as hydroxyapatite and bioactive glasses, a special type of ceramic, have been used to induce de novo osteogenesis in periosteal flaps [123]. This method is also described as neo-osseous flap prefabrication and it shows particular success in early experiments [124].…”

Section: In Vivo Tissue Engineering Approachesmentioning

confidence: 99%

Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration

Papadopoulos,

Piperi,

Korkolopoulou

2024

IJMS

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Adipose-derived stem cells (ADSCs) are mesenchymal stem cells with a great potential for self-renewal and differentiation. Exosomes derived from ADSCs (ADSC-exos) can imitate their functions, carrying cargoes of bioactive molecules that may affect specific cellular targets and signaling processes. Recent evidence has shown that ADSC-exos can mediate tissue regeneration through the regulation of the inflammatory response, enhancement of cell proliferation, and induction of angiogenesis. At the same time, they may promote wound healing as well as the remodeling of the extracellular matrix. In combination with scaffolds, they present the future of cell-free therapies and promising adjuncts to reconstructive surgery with diverse tissue-specific functions and minimal adverse effects. In this review, we address the main characteristics and functional properties of ADSC-exos in tissue regeneration and explore their most recent clinical application in wound healing, musculoskeletal regeneration, dermatology, and plastic surgery as well as in tissue engineering.

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Repair of a critical‐size segmental rabbit femur defect using bioglass‐β‐TCP monoblock, a vascularized periosteal flap and BMP‐2

Pan¹,

Jiang²,

Xue³

et al. 2017

J Biomed Mater Res

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Various synthetic bone substitutes are not suitable for reconstructing critical-size bone defects. This study tested whether a bioglass-β-tricalcium phosphate (β-TCP) monoblock is effective for repairing critical-size segmental bone defects if combined with a vascularized periosteal flap and bone morphogenetic protein (BMP)-2. A femoral osteotomy with a gap size of 20 mm was created and stabilized using a plate in 40 rabbits.The defect was left untreated (group A) or repaired using a monoblock (group B), a monoblock with a vascularized periosteal flap (group C), or a monoblock with a vascularized periosteal flap and BMP-2 (group D). Bone regeneration, vascularization and monoblock degradation were analyzed after four and eight weeks using x-ray, hematoxylin-eosin, CD34 immunohistochemical and Masson's trichrome staining observation and histometric evaluation. The radiographic grading score showed a time-dependent increase from weeks 4 to 8. At 8-week postoperative, the total new regenerated bone in groups C and D was 20.0 ± 0.3 and 55.5 ± 8.0 mm , respectively, which was significantly greater than in group B. Conversely, group D showed less residual monoblock than did group C. An increase in microvessel density was also observed in groups C and D compared with group B at 4 and 8 weeks postoperative, respectively. This study suggests that bioglass-β-TCP monoblock alone exhibits poor potential to repair a 20-mm femoral defect. However, supplementation with a vascularized periosteal flap and BMP-2 led to effective vascularization and reliable bone regeneration throughout the monoblock, with concordant material degradation in a timely manner. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2148-2156, 2018.

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Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats

Cited by 16 publications

References 31 publications

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies—A Quest for Regenerative Matching Axial Vascularization

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies—A Quest for Regenerative Matching Axial Vascularization

Clinical Applications of Adipose-Derived Stem Cell (ADSC) Exosomes in Tissue Regeneration

Repair of a critical‐size segmental rabbit femur defect using bioglass‐β‐TCP monoblock, a vascularized periosteal flap and BMP‐2

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