Repair of a critical‐size segmental rabbit femur defect using bioglass‐β‐TCP monoblock, a vascularized periosteal flap and BMP‐2

Pan, Zhaohui; Jiang, Pingping; Xue, Shan; Wang, Tao; Li, Hongfei; Wang, Jianli

doi:10.1002/jbm.b.34018

Cited by 9 publications

(13 citation statements)

References 34 publications

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“…Biocompatible and biodegradable synthetic polymers, such as polylactic acid (PLA), polyglycolic acid (PGA), poly(D, L-lactide-co-glycolide) (PLGA), polyethylene glycol (PEG), poly-E-caprolactone (PCL), and polypropylene fumarate (PPF), as well as their block polymers have been evaluated as potential BMP carriers to overcome the disadvantages of natural polymers, including immunogenicity and disease transmission risk [39][40][41][42]. They are also moldable into highly porous three-dimensional scaffolds, linearly oriented scaffolds, fibers, sheets, blocks, or microspheres [26].…”

Section: Bone Regeneration By Bone Morphogenetic Protein Devicesmentioning

confidence: 99%

“…Inorganic materials as potential BMP carriers include calcium phosphate (CaP) ceramics, calcium phosphate and calcium sulfate cement, and bioglass [2,5,29,32,38,42,. The most commonly used inorganic preclinical materials are CaP ceramics, further subdivided into hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP) containing both HA and TCP at various ratios.…”

Section: Bone Regeneration By Bone Morphogenetic Protein Devicesmentioning

confidence: 99%

“…Potential therapeutical solutions for segmental bone defect restoration have been extensively evaluated in rabbits [36,41,42,61,[68][69][70][80][81][82][83][84]87,[124][125][126] (Table 3), and a defect can be created in the femur, radius, or ulna (Figure 3B,C). Regardless of the chosen anatomical site, the typical defect size is 15-20 mm.…”

Section: Intermediate Evaluation In Rabbits 321 Segmental Defect Modelmentioning

confidence: 99%

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Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

et al. 2021

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Bone morphogenetic proteins (BMPs) possess a unique ability to induce new bone formation. Numerous preclinical studies have been conducted to develop novel, BMP-based osteoinductive devices for the management of segmental bone defects and posterolateral spinal fusion (PLF). In these studies, BMPs were combined with a broad range of carriers (natural and synthetic polymers, inorganic materials, and their combinations) and tested in various models in mice, rats, rabbits, dogs, sheep, and non-human primates. In this review, we summarized bone regeneration strategies and animal models used for the initial, intermediate, and advanced evaluation of promising therapeutical solutions for new bone formation and repair. Moreover, in this review, we discuss basic aspects to be considered when planning animal experiments, including anatomical characteristics of the species used, appropriate BMP dosing, duration of the observation period, and sample size.

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Section: Bone Regeneration By Bone Morphogenetic Protein Devicesmentioning

confidence: 99%

Section: Bone Regeneration By Bone Morphogenetic Protein Devicesmentioning

confidence: 99%

Section: Intermediate Evaluation In Rabbits 321 Segmental Defect Modelmentioning

confidence: 99%

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Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

et al. 2021

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“…Acquiring the tissue requires additional surgical procedures and creates significant donor site morbidities, accompanied by, for example, reduced function of the donor site, additional scarring, and increased pain for the patient (Betz, 2002). A recent study in rabbits showed how the use of a vascularized periosteal flap in combination with a bioglass-β-TCP monoblock and BMP-2 supplementation was effective in repairing a large femoral defect (Pan et al, 2018), emphasizing that indeed prevascularization strategies are effective in preclinical models of critical size defects.…”

Section: Importance To Patients Post-implantationmentioning

confidence: 99%

Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization

Rademakers

Horvath

Blitterswijk

et al. 2019

J Tissue Eng Regen Med

113

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The field of tissue engineering is making great strides in developing replacement tissue grafts for clinical use, marked by the rapid development of novel biomaterials, their improved integration with cells, better‐directed growth and differentiation of cells, and improved three‐dimensional tissue mass culturing. One major obstacle that remains, however, is the lack of graft vascularization, which in turn renders many grafts to fail upon clinical application. With that, graft vascularization has turned into one of the holy grails of tissue engineering, and for the majority of tissues, it will be imperative to achieve adequate vascularization if tissue graft implantation is to succeed. Many different approaches have been developed to induce or augment graft vascularization, both in vitro and in vivo. In this review, we highlight the importance of vascularization in tissue engineering and outline various approaches inspired by both biology and engineering to achieve and augment graft vascularization.

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“…Therefore, various scaffolds have been developed to overcome these limitations. At present, a large proportion of the scaffolds designed to address the reconstruction of segmental bone defects are composed of synthetic materials (e.g., ceramics, alloys, and polymers), which incorporate proteins (e.g., bone morphogenetic proteins, vascular endothelial growth factor, and stromal cell‐derived factor‐1α) and/or cells (e.g., mesenchymal stem cells and adipose‐derived stem cells) because the synthetic scaffold materials alone are inadequate to facilitate the reconstruction of critical‐sized bone defects 8‐24 . However, the use of either proteins or cells is accompanied by a higher cost and an increased likelihood of adverse effects, stemming from difficulties in controlling proteins and cells.…”

Section: Introductionmentioning

confidence: 99%

Reconstruction of critical‐size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds

Sakemi

Hayashi

Tsuchiya

et al. 2021

J Biomedical Materials Res

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Critical‐size segmental defects are formidable challenges in orthopedic surgery. Various scaffolds have been developed to facilitate bone reconstruction within such defects. Many previously studied scaffolds achieved effective outcomes with a combination of high cost, high‐risk growth factors or stem cells. Herein, we developed honeycomb scaffolds (HCSs) comprising carbonate apatite (CO3Ap) containing 8% carbonate, identical to human bone composition. The CO3Ap HCSs were white‐columned blocks harboring regularly arranged macropore channels of a size and wall thickness of 156 ± 5 μm and 102 ± 10 μm, respectively. The compressive strengths of the HCSs parallel and perpendicular to the macropore channel direction were 51.0 ± 11.8 and 15.6 ± 2.2 MPa, respectively. The HCSs were grafted into critical‐sized segmental defects in rat femurs. The HCSs bore high‐load stresses without any observed breakage. Two‐weeks post‐implantation, calluses formed around the HCSs and immature bone formed in the HCS interior. The calluses and immature bone matured until 8 weeks via endochondral ossification. At 12 weeks post‐implantation, large parts of the HCSs were gradually replaced by newly formed bone. The bone reconstruction efficacy of the CO3Ap HCSs alone was comparable to that of protein and cell scaffolds, while achieving a lower cost and increased safety.

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Repair of a critical‐size segmental rabbit femur defect using bioglass‐β‐TCP monoblock, a vascularized periosteal flap and BMP‐2

Cited by 9 publications

References 34 publications

Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

Bone Morphogenetic Proteins, Carriers, and Animal Models in the Development of Novel Bone Regenerative Therapies

Oxygen and nutrient delivery in tissue engineering: Approaches to graft vascularization

Reconstruction of critical‐size segmental defects in rat femurs using carbonate apatite honeycomb scaffolds

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