Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

Yuan, Jing; Jia, Ping; Zhou, Jian

doi:10.3389/fendo.2022.890053

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Previous cross-sectional studies had reported higher BMD in people with T2DM compared with individuals without diabetes ( 4 – 6 ). The findings from our prospective POP-ABC study demonstrate a similar association between BMD and prediabetes, consistent with previous findings from cross-sectional surveys ( 19 , 20 ). Exploring possible mechanisms, we observed significant correlations between baseline BMD and measures of adiposity and glucose tolerance (2hPG) among our study participants.…”

Section: Discussionsupporting

confidence: 91%

“…In one report, based on data from the U.S. National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2014, adults 40 years of age or older with prediabetes had higher BMD but greater hip fracture risk compared with adults with normal glucose tolerance ( 19 ). In another cross-sectional study (based on NHANES 2005-2018 data), there was an increasing trend of BMD at the hip, femoral neck, and lumbar spine across the glycemic spectrum from normoglycemia, prediabetes, to diabetes in adults aged 40 years or older ( 20 ). However, these cross-sectional observations do not reveal the direction of the association between BMD and diabetes or prediabetes, nor do they permit causal inferences.…”

Section: Introductionmentioning

confidence: 99%

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Association of bone mineral density with prediabetes risk among African-American and European-American adult offspring of parents with type 2 diabetes

Liu

Asuzu²,

Patel³

et al. 2023

Front. Endocrinol.

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IntroductionType 2 diabetes mellitus (T2DM) is associated with alterations in bone mineral density (BMD), but association between prediabetes and BMD is unclear.MethodsWe analyzed BMD among the initially normoglycemic participants in the Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study in relation to incident prediabetes during 5 years of follow-up.Results and DiscussionA total of 343 participants (193 Black, 150 White) underwent DEXA during Year 1 of POP-ABC and were followed quarterly for 5 years. The mean age was 44.2 ± 10.6 years; BMI was 30.2 ± 7.23 kg/m2. At baseline, the mean BMD was 1.176 ± 0.135 g/cm2 (1.230 ± 0.124 g/cm2 in men vs. 1.154 ± 0.134 g/cm2 in women, P<0.0001; 1.203 ± 0.114 g/cm2 in Black vs. 1.146 ± 0.150 g/cm2 in White participants, P=0.0003). During 5 years of follow-up, 101 participants developed prediabetes and 10 subjects developed T2DM (progressors); 232 were nonprogressors. Progressors to prediabetes had numerically higher baseline BMD and experienced lower 1-year decline in BMD (P<0.0001) compared with nonprogressors. From Kaplan-Meier analysis, the time to 50% prediabetes survival was 2.15 y among participants in the lowest quartile of baseline BMD, longer than those in higher quartiles (1.31 – 1.41 y). Values for BMD correlated inversely with age and adiponectin levels, and positively with BMI. In logistic regression analysis, BMD z score significantly predicted incident prediabetes: more negative BMD z scores were associated with decreased incident prediabetes (odds ratio 0.598 [95% confidence interval 0.407 - 0.877], P=0.0085), after controlling for age, BMI, change in BMI, ethnicity, blood glucose and adiponectin.ConclusionsAmong initially normoglycemic individuals, higher baseline BMD was associated with higher risk of incident prediabetes during 5 years of follow-up.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association of bone mineral density with prediabetes risk among African-American and European-American adult offspring of parents with type 2 diabetes

Liu

Asuzu²,

Patel³

et al. 2023

Front. Endocrinol.

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“…In the subgroup analysis, we found that the negative association between FPG trajectory and osteoporosis risk was significant in women. This corresponded with the study conducted by previous studies ( 9 , 25 ). Moreover, we found the significant association only existed among premenopause women.…”

Section: Discussionsupporting

confidence: 91%

Association between trajectories of fasting plasma glucose and risk of osteoporosis in non-diabetic and diabetic populations

Wang

Zhang²,

Shan

et al. 2022

Front. Public Health

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IntroductionPrevious studies based on a single measure of fasting plasma glucose (FPG) showed an inconsistent conclusion about the association between FPG and osteoporosis risk. Not accounting for time-varying and cumulative average of FPG over time could bias the true relation between FPG and osteoporosis. Our study aims to investigate the association between the trajectories of FPG and osteoporosis risk for non-diabetic and diabetic populations.MethodsA total of 18,313 participants who attended physical examinations during 2008–2018 were included. They were free of osteoporosis at their first physical examination and followed until their last physical examination before December 31, 2018. We recorded their incidence of osteoporosis and at least three FPG values during follow-up. Their longitudinal FPG trajectories were identified by the latent class growth analysis model based on the changes in FPG. Multivariable logistic regression models were used to analyze the association between the trajectories of FPG and osteoporosis diagnosed in the follow-up physical examination in both non-diabetics and diabetics.ResultsThere were 752 incident osteoporosis among 16,966 non-diabetic participants, and 57 incident osteoporosis among 1,347 diabetic participants. Among non-diabetics, the elevated-increasing FPG trajectory was negatively associated with osteoporosis risk in women (odds ratio (OR), 0.62; 95% confidence interval (CI), 0.43–0.88). Premenopausal women with elevated-increasing FPG trajectory had lower osteoporosis risk than those women with normal-stable FPG trajectory (OR, 0.41; 95% CI, 0.20–0.88), while this association was insignificant in postmenopausal women. Among diabetics, those whose longitudinal FPG is kept at a very high level had the highest risk of osteoporosis (OR, 3.09; 95% CI, 1.16–8.22), whereas those whose FPG starts with the high level and keeps on increasing did not exhibit a significantly increased risk (OR, 1.75; 95% CI, 0.81–3.76) compared with those who keep stable moderate-high level of FPG, except in men (OR, 2.49; 95% CI, 1.02–6.12).ConclusionDistinct trajectories of FPG are associated with differential risk of osteoporosis in non-diabetic and diabetic populations. Controlling a proper FPG level in different populations is necessary for osteoporosis prevention.

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“…“Hypertension” was defined as having an SBP ≥ 140 or/and DBP ≥90 mmHg or a history of hypertension [ 30 ]. Diabetes status was confirmed when the participants had a positive history of diabetes and/or elevated glycosylated hemoglobin (HbA1c) > 6.5% [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males

Chen

Huang

Zhou

et al. 2022

International Journal of Endocrinology

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Objectives. Thyroid hormone is acknowledged as a pivotal factor in skeletal development and adult bone maintenance. However, available data about the relationship between sensitivity to thyroid hormone and bone mineral density (BMD) remain limited and conflicting. The purpose of the study was to explore the complex relationship between sensitivity to thyroid hormone indices and BMD using cross-sectional analysis. Methods. An overall sample of 3,107 males from the National Health and Nutrition Examination Survey (NHANES) was studied in the study. The thyroid hormone sensitivity indices included free triiodothyronine/tree thyroxine (FT3/FT4), thyroid-stimulating hormone index (TSHI), thyrotroph thyroxine resistance index (TT4RI), and thyroid feedback quantile-based index (TFQI). Given the complex study design and sample weights, the correlation between sensitivity to thyroid hormone indices and BMD was evaluated through multivariate linear regression models, and extra subgroup analyses were performed to examine the robustness of the results. Results. Among the 3,107 participants, we demonstrated that FT3/FT4 was negatively correlated with lumbar BMD (β = −0.0.35, 95% CI: −0.084–0.013, P < 0.05 ). In the terms of central sensitivity to thyroid hormone, TFQI showed a significant negative relationship with the BMD of the lumbar (β = −0.018, 95% CI: −0.033 to −0.003, P < 0.05 ), total femur (β = −0.020, 95% CI: −0.035 to −0.006, P < 0.01 ), and femur neck (β = −0.018, 95% CI: −0.031 to −0.005, P < 0.01 ). In the subgroup analyses stratified by body mass index (BMI), the significant negative correlation between TFQI and lumbar BMD remained in the male participants with BMI between 18.5 and 24.9 kg/m2. Conclusions. Decreased indices of sensitivity to thyroid hormones are strongly associated with increased lumbar BMD, suggesting that the dysfunction of peripheral and central response to thyroid hormone might contribute to bone loss. In addition, FT3/FT4 and TFQI were considered to be the preferable indicators to guide the prevention and clinical treatment of osteoporosis.

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Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

Cited by 7 publications

References 34 publications

Association of bone mineral density with prediabetes risk among African-American and European-American adult offspring of parents with type 2 diabetes

Association of bone mineral density with prediabetes risk among African-American and European-American adult offspring of parents with type 2 diabetes

Association between trajectories of fasting plasma glucose and risk of osteoporosis in non-diabetic and diabetic populations

Association between Sensitivity to Thyroid Hormone Indices and Bone Mineral Density in US Males

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