Comparison of Blood Flow in Normal and Plaque Coronary Models Using Numerical Simulation

Pandey, Rupali; Kumar, Manoj; Srivastav, Vivek Kumar

doi:10.2139/ssrn.3356858

Cited by 1 publication

(1 citation statement)

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“…It is widely recognized that pulsatile condition in the coronary system has a significant impact on the blood flow and plaque formation in atherosclerosis disease. Due to the strong potential of the CFD in modeling blood flow, non-Newtonian flow, and prediction of cardiovascular diseases 3,4 it has been used widely in cardiovascular modeling. Due to a wide range of effective parameters on the arteries modeling, some simplifications have been applied in each study, and studies of limited parameters have been noticed by scientists.…”

Section: Introductionmentioning

confidence: 99%

Numerical study of the effect of hemodynamic variables on LDL concentration through the single layer of the Left Anterior Descending coronary artery (LAD) under the heart pulse

Biglarian

Seyedhossein

Firoozabadi

et al. 2022

Proc Inst Mech Eng H

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Heart attack is one of the most common causes of death in the world. Coronary artery disease is the most recognized cause of heart attack whose onset and progression have been attributed to low-density lipoprotein (LDL) passing through the wall of the artery. In this paper, hemodynamic variables as well as the concentration of LDL through the coronary porous artery at the Left Anterior Descending coronary artery (LAD), and its first diagonal branch (D1) under the heart motion investigated using computational simulation. The geometry that has been studied in this paper is the first bifurcation of Left Anterior Descending (LAD) that has been placed on a perimeter of hypothetical sphere representative of the heart geometry. Sinusoidal variations of sphere radii, simulated pulsating movement of the heart. Blood has been considered as a Newtonian and incompressible flow with pulsatile flow rate and real physiological profile. The plasma filtration boundary condition used over the walls in order to simulate the concentration of LDL to a one-layer artery wall. Variations in the concentration of LDL on the artery wall and its relation to oscillation on shear stress on the artery wall under different conditions are presented. Moreover, the effects of the pulsating inlet flow and dynamic movement of the artery are explored. The results declared that minimum shear stress and maximum LDL concentration take place at the bifurcation and on the myocardial wall which is in complete agreement with clinical studies. Furthermore, it has been shown that the heart pulse has a slight effect on the average time of concentration (0.1% increase); however, by analyzing all time steps, one could observe that the maximum concentration rises in some time steps; where this increases the possibility of LDL presence and helps them diffuse inside the artery wall.

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Section: Introductionmentioning

confidence: 99%