Comparison of biochemical markers and cervical length for predicting preterm delivery

Sunagawa, Sorahiro; Takagi, Kimiyo; Ono, Kyoko; Miyachi, Keiko; Kikuchi, Akihiko

doi:10.1111/j.1447-0756.2008.00844.x

Cited by 21 publications

(18 citation statements)

References 27 publications

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“…At a cut-off value of 3.6 mg/L of CRP, the sensitivity, specificity, positive predictive value and negative predictive value were 61.0%, 88.7%, 58.1% and 89.8% respectively. Our results are consistent with the study done by Sorahiro S, Kimiyo T et al (27) In their study of 119 patients, they found the sensitivity, specificity, positive predictive value and negative predictive value of CRP in prediction of preterm delivery as 50%, 85.7%, 55.6% and 82.8% respectively. In the study done by Mazor M, Kassis A et al, (28) the sensitivity, specificity, positive predictive value and negative predictive value of CRP in predicting preterm delivery due to intra-amniotic infection were found to be 71.5%, 73.2%, 31.3% and 93.8% respectively.…”

Section: Sensitivitysupporting

confidence: 82%

Maternal Plasma C-Reactive Protein: A Predictive Tool for Preterm Delivery

Afzal¹,

Ashraf²,

Ashraf³

2017

jemds

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BACKGROUND C-reactive protein (CRP) is a sensitive marker of systemic inflammation and maternal plasma concentrations of C-reactive protein have been studied as an aid in diagnosing subclinical infection in pregnant women who experience preterm labour and premature rupture of membranes. Objectives-To study the association of plasma C-reactive protein levels in early pregnancy with subsequent preterm delivery.

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Section: Sensitivitysupporting

confidence: 82%

Maternal Plasma C-Reactive Protein: A Predictive Tool for Preterm Delivery

Afzal¹,

Ashraf²,

Ashraf³

2017

jemds

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“…Among the 34 studies performed in symptomatic women, only seven (21%) defined preterm labor as the presence of uterine contractions with evidence of cervical changes. 45,48,55,58,60,61,68 Twelve studies (35%) did not include cervical changes in the diagnosis of preterm labor; 17,46,50,51,59,65,66,72-76 ; one study included women with or without cervical changes; 18 and 14 studies did not report clearly on the definition of preterm labor. 47,49,52-54,56,57,62-64,67,69-71 All studies were limited to women with intact membranes.…”

Section: Resultsmentioning

confidence: 99%

Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis

Conde-Agudelo

Romero

2016

American Journal of Obstetrics and Gynecology

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OBJECTIVE To assess the accuracy of the cervical phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) test to predict preterm birth in women with and without symptoms of preterm labor through use of formal methods for systematic reviews and meta-analytic techniques. DATA SOURCES PubMed, Embase, Cinahl, Lilacs, and Medion (all from inception to June 20, 2015), reference lists, conference proceedings, and Google scholar. STUDY ELIGIBILITY CRITERIA Cohort or cross-sectional studies that reported on the predictive accuracy of cervical phIGFBP-1 test for preterm birth. STUDY APPRAISAL AND SYNTHESIS METHODS Two reviewers independently selected studies, assessed risk of bias, and extracted data. Summary receiver operating characteristic curves, pooled sensitivities and specificities, and summary likelihood ratios were generated. RESULTS Forty-three studies met the inclusion criteria of which 15 provided data on asymptomatic women (n=6583) and 34 on women with an episode of preterm labor (N=3620). Among asymptomatic women, the predictive accuracy of cervical phIGFBP-1 test for preterm birth at <37, <34 and <32 weeks of gestation was minimal with pooled sensitivities and specificities, and summary positive and negative likelihood ratios ranging from 14-47%, 76-93%, 1.5-4.4, and 0.6-1.0, respectively. Among women with an episode of preterm labor, the test had a low predictive performance for delivery within 7 and 14 days of testing, and preterm birth at <34 and <37 weeks of gestation with pooled sensitivities and specificities, and summary positive and negative likelihood ratios that varied between 60 and 68%, 77 and 81%, 2.7 and 3.5, and 0.4 and 0.5, respectively. A negative test result in women with an episode of preterm labor had a low to moderate accuracy to identify women who are not at risk for delivering within the next 48 hours (summary negative likelihood ratio of 0.28 in all women and 0.23 in women with singleton gestations). CONCLUSION Cervical phIGFBP-1 has potential utility to identify patients with an episode of preterm labor who will not deliver within 48 hours. However, its overall predictive ability for the identification of symptomatic and asymptomatic women at risk for preterm birth is limited.

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“…To date, there is evidence that both term and preterm labor are linked to an inflammatory process, and over the last few decades several biomarkers, including inflammatory cytokines, have been investigated for the prediction of PTB. Recently, Abbot et al .…”

Section: Discussionmentioning

confidence: 99%