Comparison of Bioactive Glass Synthetic Bone Graft Particles and Open Debridement in the Treatment of Human Periodontal Defects. A Clinical Study

Abstract

The purpose of this study was to compare the repair response of bioactive glass synthetic bone graft particles and open debridement in the treatment of human periodontal osseous defects. Fifty-nine defects in 16 healthy adults were selected. Each patient had at least 2 sites with attachment loss of at least 6 mm with clinical and radiographic evidence of intrabony or furcation defects. One to 3 months after cause-related therapy (oral hygiene instructions, scaling and root planing), the following measurements were recorded prior to surgery: probing depths, clinical attachment level, and gingival recession. Each defect was surgically exposed and measurements made of the alveolar crest height and base of osseous defect. The test defects were implanted with bioactive glass. The other sites served as unimplanted controls. Flaps were sutured at or close to the presurgical level. Radiographs and soft tissue presurgical measurements were repeated at 6, 9, and 12 months. At 12 months all sites were surgically re-entered to record osseous measurements. At the 12-month evaluation, significantly greater mean probing depth reduction was noted in the bioactive glass group compared to the controls (4.26 mm versus 3.44 mm; P = 0.028). Clinical attachment level gain was significantly improved (P = 0.0004) in the bioactive glass sites (2.96 mm) compared to the control sites (1.54 mm). There was significantly less gingival recession in the bioactive glass sites (1.29 mm) compared to the control sites (1.87 mm). Defect fill was significantly greater in the bioactive glass sites (3.28 mm) compared to the control sites (1.45 mm). Defect depth reduction was significantly greater in the bioactive glass sites (4.36 mm) compared to the control sites (3.15 mm). In conclusion, bioactive glass showed significant improvement in clinical parameters compared to open flap debridement.

Particulate bioglass in the regeneration of alveolar bone in dogs: clinical, surgical and radiographic evaluations

“…Furthermore, the great capacity of Bioglass cohesion resulted in adequate compaction of the material and consequently in bleeding reduction. These findings are consistent with those reported by DeForge (1997) and Froum et al (1998), who described the cohesion ability of Bioglass upon contact with bodily fluids, which prevents migration of material from the surgical site (Fig. 1C) in addition to its hemostatic effect.…”

Evaluation of Autogenous Cortical Bone Particulate with Bioactive Glass-Synthetic Hydroxyapatite in Treatment of Periodontal Bone Defects

“…Froum reported a comparable mean attachment gain of 3.31 ± 0.26 mm using bioactive glass [12]. Leknes (2009) reported mean gingival recession of 1mm six months following placement of PerioGlas in 13 intrabony defects [13].…”

A Comparative Clinical and Radiological Study Using Biograft-Habg Active and Biograft –Cpc.

“…5(3), 1080-1089 1081 therapeutic modalities have been considered to arrest the disease progression and to regenerate the lost tissue. Periodontal surgical procedures have focused on the elimination of hard and soft tissue defects (i.e., probing depths and osseous defects) by regenerating new attachment (Froum et al, 1998). Reconstructive modalities that appear to have merit and have demonstrated significant gain of clinical attachment include: surgical debridement with adjunctive root surface or wound conditioning, implantation of bone, bone derivatives and substitutes, and placement of barrier membranes for guided tissue regeneration ( Becker et al 1999).…”