2014
DOI: 10.1016/j.pbb.2014.01.012
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Comparison of behavioral and biochemical deficits in rats with hereditary defined or d-galactose-induced accelerated senescence: Evaluating the protective effects of diosgenin

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Cited by 26 publications
(18 citation statements)
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“…Also, defecation and urination in the open field and plus-maze was similar in all groups of rats, showing similar emotionality during the experiment. These results corroborate previous studies 12,18,20 that did not find alterations in the exploratory locomotor activity and anxiety levels in the openfield test associated with d-galactose treatment.…”
Section: Discussionsupporting
confidence: 92%
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“…Also, defecation and urination in the open field and plus-maze was similar in all groups of rats, showing similar emotionality during the experiment. These results corroborate previous studies 12,18,20 that did not find alterations in the exploratory locomotor activity and anxiety levels in the openfield test associated with d-galactose treatment.…”
Section: Discussionsupporting
confidence: 92%
“…18,20 On the contrary, there are several studies 12,14,23,62 that reported impairments of the spatial learning and memory induced by d-galactose treatment. Indeed, in a study where C57BL/6 mice were used, there were deficits in spatial learning and memory but curiously, non-spatial cognitive ability such as novelty-seeking behavior was not affected.…”
Section: Discussionmentioning
confidence: 99%
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“…The latter may evidence compensatory mechanisms that explain the absence of significant changes in olfactory function. Interestingly, earlier we found the decreased sexual motivation in 5-months old OXYS males [39]. The present findings suggested that olfactory dysfunction was not involved in the disturbances of sexual behavior in OXYS males.…”
Section: Discussionsupporting
confidence: 49%