Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI

Tikhonova, Maria A.; Romaschenko, A. G.; Akulov, Andrey E.; Ho, Ying-Jui; Kolosova, N. G.; Мошкин, М. П.; Amstislavskaya, Tamara G.

doi:10.1016/j.bbr.2015.08.001

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…However, there are some practical issues when studying the effects of stress on aging animals. With aging, there is increasing sensorial loss, such as sight or olfaction, which can interfere with stress perception ( Tikhonova et al., 2015 , Zeng and Yang, 2015 ). Likewise, it is important to adequate the intensity and nature of the stressors (as well as the stress read-out behavioral tests) when studying chronic stress in aged rodents ( Prusky et al., 2000 ).…”

Section: The Effect Of Age In the Stress Responsementioning

confidence: 99%

How age, sex and genotype shape the stress response

Novais

Monteiro

Roque

et al. 2017

Neurobiology of Stress

103

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Exposure to chronic stress is a leading pre-disposing factor for several neuropsychiatric disorders as it often leads to maladaptive responses. The response to stressful events is heterogeneous, underpinning a wide spectrum of distinct changes amongst stress-exposed individuals'. Several factors can underlie a different perception to stressors and the setting of distinct coping strategies that will lead to individual differences on the susceptibility/resistance to stress. Beyond the factors related to the stressor itself, such as intensity, duration or predictability, there are factors intrinsic to the individuals that are relevant to shape the stress response, such as age, sex and genetics. In this review, we examine the contribution of such intrinsic factors to the modulation of the stress response based on experimental rodent models of response to stress and discuss to what extent that knowledge can be potentially translated to humans.

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Section: The Effect Of Age In the Stress Responsementioning

confidence: 99%

How age, sex and genotype shape the stress response

Novais

Monteiro

Roque

et al. 2017

Neurobiology of Stress

103

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“…Several studies have shown that despite the reduced regeneration rate of olfactory sensory neurons (OSNs), OB alterations involving a reduced number of synaptic contacts (Richard et al, 2010), expression defects of odorant receptor genes (Lee et al, 2009; Khan et al, 2013) and changes in the OSNs dynamic range (Kass et al, 2018) are of late occurrence and just becoming obvious in 2-year-old mice. Although the olfactory system may undergo age-related changes from middle age (Mobley et al, 2014), functional deficits during natural aging might exhibit a late onset, suggesting compensatory mechanisms to preserve the processing of olfactory cues like social information relevant for the survival of aged animals (Tobiansky et al, 2012; Tikhonova et al, 2015). In contrast to the steadily decline of natural aging, pathological conditions may accelerate functional deficits even in the absence of obvious structural changes of peripheral organs like the VNO, suggesting impairments in the central processing of social information.…”

Section: Discussionmentioning

confidence: 99%

Natural and pathological aging distinctively impact the vomeronasal detection system and social behavior

Portalés

Chamero

Jurado

2022

Preprint

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Normal aging and many age-related diseases such as Alzheimer disease cause deficits in olfaction, however it is currently unknown how natural and pathological aging impact the detection of social odors which might contribute to the impoverishment of social behavior at old age further worsening overall health. Here, we investigated the effect of aging in the recognition of social cues and the display of social behavior. Our findings indicate that aging distinctively disrupts the processing of social olfactory cues decreasing social odor exploration, discrimination and habituation in both wild type senescent (2-year-old) mice and in 1-year-old double mutant model of Alzheimer disease (APP/PS1). Furthermore, social novelty was diminished in 1-year-old APP/PS1 mice, indicating that alterations in the processing of social cues are accelerated during pathological aging. Analysis of the vomeronasal organ, the main gateway to pheromone-encoded information, indicated that natural and pathological aging distinctively reduce the neurogenic ability of the vomeronasal sensory epithelium. Cell proliferation remained majorly preserved in 1-year model of Alzheimer disease (APP/PS1), whereas naturally aged animals exhibited significant deficiencies in the number of mature, proliferative and progenitor cells. This study reveals fundamental differences in the cellular processes by which natural and pathological aging disrupt the exploration of social cues and social behavior.

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“…Animals are fixed on the scanning bed, and a transmitter sends specific odors within the animals' smell range. Specific odors include alcohol, almond flavor, amyl acetate (Poplawsky et al, 2015), ethyl butyrate, methyl valerate (Sanganahalli et al, 2016), various types of odoriferous chemicals (Zhao et al, 2018), and social smells of different species or the same species (Xu et al, 2005;Tikhonova et al, 2015) were sent through an MRI-compatible device. In olfactory stimulation experiments, it is also essential to design the parameters of odor transport location and transport time.…”

Section: Olfactory Stimulationmentioning

confidence: 99%

The current status and trend of the functional magnetic resonance combined with stimulation in animals

Huang

Zhang

et al. 2022

Front. Neurosci.

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As a non-radiative, non-invasive imaging technique, functional magnetic resonance imaging (fMRI) has excellent effects on studying the activation of blood oxygen levels and functional connectivity of the brain in human and animal models. Compared with resting-state fMRI, fMRI combined with stimulation could be used to assess the activation of specific brain regions and the connectivity of specific pathways and achieve better signal capture with a clear purpose and more significant results. Various fMRI methods and specific stimulation paradigms have been proposed to investigate brain activation in a specific state, such as electrical, mechanical, visual, olfactory, and direct brain stimulation. In this review, the studies on animal brain activation using fMRI combined with different stimulation methods were retrieved. The instruments, experimental parameters, anesthesia, and animal models in different stimulation conditions were summarized. The findings would provide a reference for studies on estimating specific brain activation using fMRI combined with stimulation.

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Comparative study of perception and processing of socially or sexually significant odor information in male rats with normal or accelerated senescence using fMRI

Cited by 6 publications

References 41 publications

How age, sex and genotype shape the stress response

How age, sex and genotype shape the stress response

Natural and pathological aging distinctively impact the vomeronasal detection system and social behavior

The current status and trend of the functional magnetic resonance combined with stimulation in animals

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