Comparison of ASTK, CK, CK-MB, and LD for the estimation of acute myocardial infarct size in man

Grande, Peer; Christiansen, Claus; Alstrup, Knud

doi:10.1016/0009-8981(83)90332-7

Cited by 40 publications

(16 citation statements)

References 14 publications

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“…We were thus able to confirm earlier experiments showing reduced infarct size in animals fed FO [18][19][20][21][22]. Peak values of enzymes can be used as indicators of infarct size in groups of patients to be compared [29]. The mechanisms by which FO protects against myocardial necrosis are incompletely understood and probably related to several factors.…”

Section: Discussionsupporting

confidence: 69%

Use of Fish Oils Appears to Reduce Infarct Size as Estimated from Peak Creatine Kinase and Lactate Dehydrogenase Activities

et al. 1998

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In 753 patients with acute myocardial infarction, use of fish oils (FO, n = 242) before onset of infarction seemed to reduce infarct size as estimated from peak creatine kinase (CK_max) and lactate dehydrogenase (LD_max) activities. The study had an observational exposed/nonexposed design, and both crude and adjusted effects were looked for. Crude Effects: In the restricted cohort of patients not receiving thrombolytic treatment (n = 411), FO reduced CK_max from 879 to 759 U/l (2 p = 0.030) and LD_max from 870 to 768 U/l (2 p = 0.011), respectively. More of these patients in the lowest enzyme quartiles used FO, p for linear trend was for CK_max 0.008 and for LD_max 0.06, respectively. Adjusted Effects: In patients not receiving thrombolytic treatment, FO reduced CK_max (2 p = 0.007) and LD_max (2 p = 0.005), but in patients receiving such treatment, CK_max and LD_max values increased, 2 p being 0.036 and 0.097, respectively. In patients not receiving thrombolysis, FO increased the incidence of small infarcts (the 25% quartile), odds ratio for CK_max was 1.82 (2 p = 0.018) and for LD_max 1.66 (2 p = 0.048), respectively. The results indicate that FO may reduce infarct size and the incidence of large infarcts. In addition, FO seems to enhance the effect of thrombolysis.

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Section: Discussionsupporting

confidence: 69%

Use of Fish Oils Appears to Reduce Infarct Size as Estimated from Peak Creatine Kinase and Lactate Dehydrogenase Activities

et al. 1998

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“…In this study we used enzymes as a measurement of infarct size. Although a good correlation has been described between peak serum enzyme activity and infarct size estimated at autopsy [22,23], it is clear that other factors than the extent of the infarction might influence this correlation such as me tabolism, excretion and myocardial wash out.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Herlítz¹,

Helgesson²,

Hjalmarson³

et al. 1986

Cardiology

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In 585 patients with a first myocardial infarction the enzymatically estimated infarct size was related to the clinical course during a 2-year follow-up. Infarct size was estimated from maximum heat-stable lactate dehydrogenase activity. A higher maximum serum activity was associated with a higher mortality rate, more treatment with diuretics, digitalis and antiarrhythmics and a lower frequency of return to work. Patients with smaller infarcts according to maximum serum activity, however, had a higher incidence of angina pectoris and a higher reinfarction rate. We conclude that although there is a strong association between serum enzyme activity and mortality during a 2-year follow-up, the relation with morbidity appears to be more complex.

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“…Cardiac biomarkers such as CK-MB and different types of cardiac troponins have gained increasing utility due to their ability in the diagnosis, stratification and also prediction of patients` outcome following acute coronary syndromes (29)(30)(31). There is convincing evidence from several trials that CK-MB and cardiac troponins I and/or T are also useful for rough estimation of the extent of myocardial damage (8)(9)(10)(32)(33)(34). The major limitation of cytoplasmic enzymes such as CK or CK-MB in the estimation of infarct size is the need for serial measurements to identify peak or cumulative serum concentrations.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome is associated with higher wall motion score and larger infarct size after acute myocardial infarction

Chitsazan¹,

Hajsadeghi²,

Chitsazan³

et al. 2015

Res Cardiovasc Med

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Background:Infarct size is an important surrogate end point for early and late mortality after acute myocardial infarction. Despite the high prevalence of metabolic syndrome in patients with atherosclerotic diseases, adequate data are still lacking regarding the extent of myocardial necrosis after acute myocardial infarction in these patients. Objectives: In the present study we aimed to compare myocardial infarction size in patients with metabolic syndrome to those without metabolic syndrome using peak CK-MB and cardiac troponin I (cTnI) at 72 hours after the onset of symptoms. Patients and Methods: One-hundred patients with metabolic syndrome (group I) and 100 control subjects without metabolic syndrome (group II) who experienced acute myocardial infarction were included in the study. Diagnosis of metabolic syndrome was based on the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines published in 2001. Myocardial infarction size was compared between the two groups of patients using peak CK-MB and cTnI level in 72 hours after the onset of symptoms. Results: Peak CK-MB and cTnI in 72 hours were found to be significantly higher in patients with metabolic syndrome compared with control subjects (both P < 0.001). Patients with metabolic syndrome also had markedly higher wall motion abnormality at 72 hours after the onset of symptoms as assessed by echocardiographically-derived Wall Motion Score Index (WMSI) (P < 0.001). Moreover, statistically significant relationships were found between WMSI and peak CK-MB and also cTnI at 72 hours (Spearman's rho = 0.56, P < 0.001 and Spearman's rho = 0.5, P < 0.001; respectively). However, association between WMSI and left ventricular ejection fraction was insignificant (Spearman's rho = -0.05, P = 0.46). Conclusions:We showed that patients with metabolic syndrome have larger infarct size compared to control subjects.

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Comparison of ASTK, CK, CK-MB, and LD for the estimation of acute myocardial infarct size in man

Cited by 40 publications

References 14 publications

Use of Fish Oils Appears to Reduce Infarct Size as Estimated from Peak Creatine Kinase and Lactate Dehydrogenase Activities

Use of Fish Oils Appears to Reduce Infarct Size as Estimated from Peak Creatine Kinase and Lactate Dehydrogenase Activities

Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Metabolic syndrome is associated with higher wall motion score and larger infarct size after acute myocardial infarction

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