Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Herlítz, Johan; Helgesson, I; Hjalmarson, B-M; Hjalmarson, Å.; Jonsteg, C; Sudow, B von; Waldenström, J

doi:10.1159/000173988

Cited by 6 publications

(1 citation statement)

References 11 publications

(15 reference statements)

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“…It has been shown that early intervention with streptoki nase [1,2] and with beta-blockers [3,4] can reduce the early mortality and regarding beta-blockade several morbidity aspects in the early phase appear to be favorably af fected. The relationship between the original infarct size and long-term morbidity, how ever, appears to be more complex [5] and not much is known whether limitation of the infarct size can improve morbidity and qual ity of life in a longer perspective. In this paper we report on morbidity and quality of life during a 5-year follow-up after early in tervention with metoprolol in patients with suspected acute myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Morbidity and Quality of Life 5 Years after Early Intervention with Metoprolol in Suspected Acute Myocardial Infarction

Herlitz

Bengtson²,

Hjalmarson³

1988

Cardiology

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In 1,395 patients in the age range 40-74 years participating in a double-blind trial with metoprolol in suspected acute myocardial infarction morbidity and quality of life were assessed during the first 5 years after randomization. During the first 3 months patients were given 200 mg metoprolol daily or placebo. Thereafter the two groups were treated similarly. Mortality during 5 years was 24.2% in patients originally randomized to metoprolol versus 25.7% in patients originally randomized to placebo (p > 0.2). No difference was observed regarding reinfarction rate, stroke or occurrence of bypass surgery during the 5-year follow-up. During the first 3 months 10% of patients in the metoprolol group were rehospitalized for various reasons versus 13 % in the placebo group. The corresponding figures for 5 years were 59 and 60%, respectively. Among patients surviving 5 years 84% in both groups were on some medication of which beta-blockade was the dominating one. Symptoms of chest pain, dyspnea, claudicatio, smoking habits and working capacity did not differ and neither did quality of life according to the Nottingham Health Profile. We thus conclude that morbidity and quality of life were not significantly affected 5 years after early intervention with metoprolol in patients with suspected acute myocardial infarction.

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Section: Introductionmentioning

confidence: 99%

Morbidity and Quality of Life 5 Years after Early Intervention with Metoprolol in Suspected Acute Myocardial Infarction

Herlitz

Bengtson²,

Hjalmarson³

1988

Cardiology

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Morbidity during five years after myocardial infarction and its relation to infarct size

Herlitz

Bengtson

Hjalmarson

et al. 1988

Clinical Cardiology

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Summary:In 809 patients with a recent myocardial infarction, morbidity during 5-year follow-up was assessed. The overall 5-year mortality rate was 33% (39% in patients with larger infarcts and 26% in patients with smaller infarcts) as judged from maximum serum enzyme activity (p < ,001). In terms of morbidity, no significant association with estimated infarct size was observed. Patients with smaller infarcts tended to have a higher reinfarction rate and were rehospitalized more often, whereas a similar proportion of patients with large and small infarcts developed stroke. Among survivors, chest pain tended to be more common in patients having smaller infarcts, whereas symptoms of dyspnea and claudicatio intermittens were similar in both groups, as were smoking habits, work capability, and varying forms of medication. We thus conclude that during a 5-year follow-up after acute myocardial infarction, mortality, but not morbidity, was related to the original infarct size.

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The relationship between infarct size and mortality and morbidity during short-term and long-term follow-up after acute myocardial infarction

Herlitz

Hjalmarson

Lomsky

1988

American Heart Journal

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Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Cited by 6 publications

References 11 publications

Morbidity and Quality of Life 5 Years after Early Intervention with Metoprolol in Suspected Acute Myocardial Infarction

Morbidity and Quality of Life 5 Years after Early Intervention with Metoprolol in Suspected Acute Myocardial Infarction

Morbidity during five years after myocardial infarction and its relation to infarct size

The relationship between infarct size and mortality and morbidity during short-term and long-term follow-up after acute myocardial infarction

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