Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat

Alich, Agnes; Welsh, Victoria J.; Wittmers, Lorentz E.

doi:10.1002/jps.2600721222

Cited by 13 publications

(2 citation statements)

References 21 publications

(24 reference statements)

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“…The stomach was everted over the index finger and the presence or absence of gastric irritation was determined. The ulcer index for each group was determined according to a previously reported method [36] by counting the number of lesions (x) in each of five size classes (y). The classes were defined as y ¼ 1 (pinpoint lesion), y ¼ 2 (lesions <1 mm diameter), y ¼ 3 (lesions 1-2 mm diameter), y ¼ 4 (lesions 2-4 mm diameter) and y ¼ 5 (lesions > 4 mm diameter).…”

Section: Ulcerogenic Activitymentioning

confidence: 99%

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

Khode

Maddi

Aragade

et al. 2009

European Journal of Medicinal Chemistry

157

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Section: Ulcerogenic Activitymentioning

confidence: 99%

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

Khode

Maddi

Aragade

et al. 2009

European Journal of Medicinal Chemistry

157

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“…The stomach was everted over the index finger, and the presence or absence of gastric irritation was determined (Vogel, 2002). The ulcer index for each group was determined according to a previously reported method (Alich et al, 1983) by counting the number of lesions (x) in each of five size classes (y). The classes were defined as y = 1 (pinpoint lesion), y = 2 (lesions \1 mm diameter), y = 3 (lesions 1-2 mm diameter), y = 4 (lesions 2-4 mm diameter), and y = 5 (lesions [4 mm diameter).…”

Section: Ulcerogenic Activitymentioning

confidence: 99%

Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: synthesis, pharmacological evaluation, and computational insights

et al. 2014

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A novel series of methyl-2-(substituted benzylideneamino)-3-phenyl propionate (2a-j) derivatives have been synthesized. The title compounds (2a-j) were screened for in vivo acute anti-inflammatory and analgesic activities at a dose of 200 mg/kg b.w. Compound 2e exhibited the most promising and significant anti-inflammatory profile while compounds 2b, 2h, 2i, and 2j showed moderate to good inhibitory activity at 2nd and 4th h, respectively. These compounds were also found to have considerable analgesic activity (acetic acid-induced writhing model) and antipyretic activity (yeast-induced pyrexia model). In addition, the tested compounds were also found to possess less degree of ulcerogenic potential as compared to the standard NSAIDs. The synthesized compounds were further evaluated for their inhibitory activity against cyclooxygenase enzyme (COX-1/COX-2), by in vitro colorimetric COX (ovine) inhibitor screening assay method. The results revealed that the compounds 2b, 2e, 2h, 2i, and 2j exhibited selective and effective inhibition against COX-2. In an attempt to understand the ligand-protein interactions in terms of their binding affinity, docking studies were also performed using Molegro Virtual Docker (MVD-2013, 6.0) for the title compounds. It was observed that the binding affinities calculated were in agreement with the experimental IC 50 values.

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The Ulcerogenic Potential of Copper Aspirinate Seems to be More Imaginary than Real

Sorenson

1984

Journal of Pharmaceutical Sciences

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Comparison of Aspirin and Copper Aspirinate with Respect to Gastric Mucosal Damage in the Rat

Cited by 13 publications

References 21 publications

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

Synthesis and pharmacological evaluation of a novel series of 5-(substituted)aryl-3-(3-coumarinyl)-1-phenyl-2-pyrazolines as novel anti-inflammatory and analgesic agents

Novel series of phenylalanine analogs endowed with promising anti-inflammatory activity: synthesis, pharmacological evaluation, and computational insights

The Ulcerogenic Potential of Copper Aspirinate Seems to be More Imaginary than Real

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