Comparison of area under the curve in various models of diabetic rats receiving chronic medication

Liu, Keng-Fan; Niu, Chiang‐Shan; Tsai, Jen-Chieh; Yang, Chao-Lin; Peng, Wen-Huang; Niu, Ho‐Shan

doi:10.5114/aoms.2019.91471

Cited by 10 publications

(7 citation statements)

References 48 publications

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“…for two weeks followed by a single dose of LPS on day 15 ( Figure 1 ). The doses of DAPA and LPS and the routes of administration were selected following previous protocols [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Dapagliflozin Mitigates Hypotension in Lipopolysaccharide-Induced Acute Inflammation Independent of Glycemia Level

et al. 2023

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Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been suggested to have anti-inflammatory properties in diabetes. The goal of this study was to evaluate the role of the SGLT2 inhibitor dapagliflozin (DAPA) in the attenuation of lipopolysaccharide (LPS)-induced hypotension. Male Wistar albino rats were divided into normal and diabetic groups and received DAPA (1 mg/kg/day) for two weeks followed by a single dose of 10 mg/kg LPS. Blood pressure was recorded throughout the study and the circulatory levels of cytokines were assessed using a multiplex array, while the aortas were harvested for analysis. DAPA attenuated the vasodilation and hypotension caused by LPS. Mean arterial pressure (MAP) was preserved in the normal and diabetic DAPA-treated septic groups (MAP = 83.17 ± 5.27, 98.43 ± 5.57 mmHg) compared to the vehicle-treated septic groups (MAP = 65.60 ± 3.31, 68.21 ± 5.88 mmHg). Most of the cytokines induced by LPS were decreased in the DAPA-treated septic groups. In the aorta, the inducible nitric oxide synthase-derived nitric oxide had lower expression in the DAPA-treated rats. In contrast, the expression of α-smooth muscle actin, a marker of the vessel’s contractile state, was higher in the DAPA-treated rats in comparison with non-treated septic rats. These findings revealed that the protective role of DAPA against LPS-induced hypotension is likely to be glucose-lowering independent, as was observed in the non-diabetic septic group. Taken together, the results show that DAPA has a potential effect in the prevention of the hemodynamic disturbances of sepsis regardless of glycemia levels.

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“…for two weeks followed by a single dose of LPS on day 15 ( Figure 1 ). The doses of DAPA and LPS and the routes of administration were selected following previous protocols [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Dapagliflozin Mitigates Hypotension in Lipopolysaccharide-Induced Acute Inflammation Independent of Glycemia Level

et al. 2023

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“…and Insulin (1 IU, sc.) were used as the test drugs (Ismail et al, 2013;John et al, 2015;Liu et al, 2020).…”

Section: Chemicals and Drugsmentioning

confidence: 99%

Beneficial effects of Insulin and Rivastigmine in Type-3 Diabetes mellitus in rats

Ahlawat¹,

Walia²,

Garg³

2023

J App Pharm Sc

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Type-3 diabetes mellitus (T3D) is a pathological condition that possesses the characteristics of both Diabetes and Alzheimer's disease, considered as brain diabetes. Treatment of T3D is still a challenging task for clinical practitioners. In this regard, this study was carried out to explore the effect of Insulin and Rivastigmine in the experimental rats. T3D was induced by administering streptozotocin (STZ; 35 mg/kg, i.p., single dose) followed by daily administration of aluminum chloride (AlCl 3 ) (12.5 mg/kg, i.p. × 28 days). The Insulin (1 IU s.c. daily × 28 days) and Rivastigmine (1 mg/kg, i.p. × 28 days) treatment was given 30 minutes prior to administration of AlCl 3 . After 28 days of treatment, the rats were subjected to the estimation of various behavioral parameters using elevated plus maze (EPM) and Morris water maze (MWM) test and biochemical parameters including Insulin, glucose, malondialdehyde (MDA), nitrite, and amyloid beta (Aβ) levels. The results obtained revealed that the Insulin administration increased the square crossings in the open field, and reduced the transfer latency of T3D rats in the closed arm of EPM at day 2 and the frequency of platform crossing in the MWM test in T3D rats. The administration of Insulin and Rivastigmine reduced the blood glucose level and Aβ levels in the brain of T3D rats. Furthermore, Rivastigmine treatment also reduced the brain Insulin level of T3D rats. These studies indicate toward the beneficial effects of Insulin and Rivastigmine that open newer opportunities in the management protocol of T3D.

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“…All animals were then observed for 2 weeks followed by blood glucose level measurement using a or table glucometer (Accu-Check Active; Roche Diagnostic Corporation, Germany) in the blood collected from tail vein. Animals with fasting blood glucose level between 200 and 350 mg/dL were considered as diabetic and used for the study (Liu et al, 2022). After 4 weeks of development of diabetes, 20 diabetic rats were randomly selected and subjected to neurobehavioral studies to assess learning and memory impairments (Mehta and Banerjee, 2017).…”

Section: Experimental Induction Of Type 2 Diabetes Mellitusmentioning

confidence: 99%

The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction

Tientcheu,

Ngueguim,

Gounoue

et al. 2023

Metab Brain Dis

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Diabetes-associated cognitive dysfunction is linked to chronic hyperglycemia, oxidative stress, in ammation, cholinergic dysfunction, and neuronal degeneration. We investigated the antidiabetic and neuroprotective activity of a mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) in type 2 diabetic (T2D) rat model-induced memory impairment. Fructose (10%) and streptozotocin (35 mg/kg) were used to induce T2D in male Wistar rats. Diabetic animals received distilled water, metformin (200 mg/kg), or SNP mixture (75, 150, or 300 mg/kg). HPLC-MS pro ling of the mixture was performed.Behavioral testing was conducted using the Y-maze, NORT, and Morris water mazes to assess learning and memory. Biochemical markers were evaluated, including carbohydrate metabolism, oxidative/nitrative stress, pro-in ammatory markers, and acetylcholinesterase activity. Histopathological examination of the pancreas and hippocampus was also performed. Fructose/STZ administration resulted in T2D, impaired short-and long-term memory, signi cantly increased oxidative/nitrative stress, pro-in ammatory cytokine levels, acetylcholinesterase activity (AChE), hippocampal neuronal loss and degeneration in CA1 and CA3 sub elds, and neuronal vacuolation in DG. SNP mixture at 150 and 300 mg/kg signi cantly improved blood glucose and memory function in diabetic rats. The mixture reduced oxidative/nitrative stress and increased endogenous antioxidant levels. It also reduced serum IL-1β, INF-γ and TNF-α levels and ameliorated AChE activity. Histologically, SNP protected hippocampus neurons against T2D-induced neuronal necrosis and degeneration. We conclude that the aqueous extract of SNP mixture has antidiabetic and neuroprotective activities thanks to active metabolites identi ed in the plant mixture, which consequently normalized blood glucose, protected hippocampus neurons, and improved memory function in diabetic rats. HighlightsThe aqueous extract of the mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) demonstrated neuroprotective and memory-strengthening properties by protecting hippocampus neurons in diabetic rats; Antidiabetic properties of the SNP mixture were exhibited via normalization of blood glucose levels and pancreas protection; SNP activity was due to the main naturally-occurring substances identi ed.

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Comparison of area under the curve in various models of diabetic rats receiving chronic medication

Cited by 10 publications

References 48 publications

Dapagliflozin Mitigates Hypotension in Lipopolysaccharide-Induced Acute Inflammation Independent of Glycemia Level

Dapagliflozin Mitigates Hypotension in Lipopolysaccharide-Induced Acute Inflammation Independent of Glycemia Level

Beneficial effects of Insulin and Rivastigmine in Type-3 Diabetes mellitus in rats

The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction

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