Comparison of apical periodontitis repair in endodontic treatment with calcium hydroxide-dressing and aPDT

Lopes, Zobélia Maria de Souza; Sá, Rafaela Cardoso de; Júnior, Arthur Belém Novaes; Romualdo, Priscilla Coutinho; Lucisano, Marília Pacifico; Filho, Paulo Nelson; Silva, Léa Assed Bezerra da

doi:10.1590/1807-3107bor-2019.vol33.0092

Cited by 16 publications

(11 citation statements)

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“…Similarly, Garcez et al (2015), in a 3-year clinical follow-up study of periapical procedures with supplementary PDT, found a greater degree of bacterial reduction and a 78% reduction of periapical lesion area after PDT had been applied [13]. On the other hand, better resolution of periapical periodontitis with calcium hydroxide has been described in a recent canine study [29].…”

Section: Discussionmentioning

confidence: 83%

Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment

et al. 2021

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Purpose: To compare the effect of photodynamic therapy (PDT) as a procedure to complement root canal treatment (RCT), for both primary treatment and retreatment. Methods: This was a retrospective study based on analysis of clinical records. A total of 214 teeth that had undergone RCT on either a primary or retreatment basis, with or without complementary PDT, were evaluated. For 118 teeth that met the previously established inclusion criteria, the time until healing was evaluated. Complementarily, the need for application of calcium hydroxide (CaHy) between visits and the number of visits necessary for completing the treatment were assessed. Data were analyzed using the Mann-Whitney and χ 2 tests with a significance level of P < 0.05. Results: Periapical radiolucency resolution was achieved at 15 ± 9.33 months in the RCT + PDT group and 20.35 ± 22.1 months in the RCT group (P = 0.07). For primary treatment, CaHy was necessary in 72.4% of the RCT cases and 16.4% of the RCT + PDT cases (P < 0.01). For retreatment cases, CaHy was used in 82.7% of the RCT cases and 17% of the RCT + PDT cases (P < 0.01). In the RCT group, more than two visits were necessary for primary treatment in 18.6% of the cases, compared with 13.10% in the RCT + PDT group (P = 0.31), whereas for retreatment, more than two visits were necessary for 64.9% and 49.1% of cases, respectively (P = 0.05). Conclusion:In comparison with RCT alone, teeth receiving RCT + PDT showed less variation in the time needed for periapical lesion healing, fewer cases required CaHy, and fewer cases required more than two visits to complete the treatment.

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Section: Discussionmentioning

confidence: 83%

Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment

et al. 2021

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“…Specifically, in Endodontics, which is one of the areas of application of PDT in Dentistry, only few studies evaluated tissue reactions to this therapy. Three of these studies [2,10,12,25], performed by our research group, evaluated the histopathologic characteristics of the periapical tissue in dog's teeth, after endodontic treatment using PDT protocols. In the present study, the evaluation of the subcutaneous tissue in mice, aimed to evaluate the tissue compatibility, without the presence of bacteria or pre-existent pathologic processes.…”

Section: Discussionmentioning

confidence: 99%

“…Both Silva et al (2012) [2] and Borsatto et al (2016) [10] highlighted that the PDT parameters could have influenced their results. Silva et al (2019) [25] suggested that the used aPDT protocol stimulated the repair process, however the CH-based dressing promoted better apical periodontitis repair. Therefore, new studies must establish a safe protocol, enabling the inactivation of bacteria without causing aggression to the host apical and periapical tissues.…”

Section: Discussionmentioning

confidence: 99%

Photosensitizers and Exposure Times To Light Showed Tissue Compatibility In Isogenic Mice

Oliveira

Pucinelli

et al. 2021

BDS

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Objective: The aim of this study was to evaluate the subcutaneous tissue response after different protocols to photodynamic therapy (PDT). In Phase 1, were tested the diode laser (used for 1min) associated to the photosensitizer phenothiazine chloride solution (PCS) in different concentrations. In Phase 2 – the diode laser and LED were tested associated to two different photosensitizers, PCS and Curcumin, in different exposure times of light application. Material and Methods: After 7, 21 and 63-days the animals were euthanized and the subcutaneous tissue processed to histological analysis. Qualitative and semi-quantitative descriptions of the inflammatory process and immunohistochemical technique were performed. The obtained data were analyzed by Kruskal-Wallis and Dunn’s post-test (alpha = 0.5). Results: On Phase 1, the tissue response was very similar among the groups. For the inflammatory infiltrate, PCS with concentration of 10mg/mL exhibited the most intense reaction (p > 0.05). On Phase 2, at 7-days period, the analyzed parameters presented small magnitude and after 21 and 63-days, all the parameters demonstrated tissue compatibility. Conclusion: Both photosensitizers presented proper tissue compatibility regardless the different concentrations used on Phase 1 and different durations of light exposure on Phase 2. Keywords Photodynamic therapy; Phenothiazine chloride solution; Curcumin; Isogenic mice; Subcutaneous tissue.

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“…Severe periodontitis is a complex condition that is difficult to treat[ 11 , 12 ]. It can lead to increased tooth mobility and pathologic migration, which may adversely affect masticatory function and esthetics[ 13 , 14 ]. The ideal treatment for severe periodontitis remains a topic of research.…”

Section: Discussionmentioning

confidence: 99%

Comparison of dental pulp periodontal therapy and conventional simple periodontal therapy as treatment modalities for severe periodontitis

Lü¹,

Chen²,

Liu³

et al. 2021

WJCC

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BACKGROUND Severe periodontitis is a major oral health concern today as it can lead to loss of teeth. Conventional periodontal therapy has numerous pitfalls as it does not address the pulp-periodontal complex in its entirety. AIM To investigate the effect of dental pulp periodontal therapy on the levels of interleukin-1β (IL-1β) and IL-10 in gingival crevicular fluid (GCF) in patients with severe periodontitis. METHODS Eighty-six patients with severe periodontitis were randomly divided into a research group ( n = 43) and a control group ( n = 43). The control group was treated with simple periodontal therapy, and the research group was treated with dental pulp periodontal therapy. The total effective rates of the treatments; periodontal status before and after treatment through the measurement of the periodontal pocket probing depth (PPD), gingival sulcus bleeding index (SBI), mobility (MD), and plaque index (PLI); the levels of inflammatory factors IL-1β and IL-10 in the GCF; and the incidence of complications were calculated for both groups and compared using the Student’s t test and the χ 2 test. RESULTS The total effective rate of treatment in the study group (93.02%) was higher than that in the control group (76.74%; P < 0.05). While before treatment, there was no significant difference in the PLI, MD, SBI, or PPD between the two groups, the post-treatment values of PLI, MD, SBI, and PPD (4.71 ± 0.16 mm, 0.61 ± 0.09 mm, 0.96 ± 0.17 mm, and 0.76 ± 0.26 mm, respectively) were significantly lower ( P < 0.05) in the research group than in the control group (5.35 ± 0.24 mm, 0.93 ± 0.15 mm, 1.35 ± 0.30 mm, and 1.04 ± 0.41 mm, respectively). There was no significant difference in the level of IL-1β or IL-10 in the GCF before treatment between the two groups; after treatment, the IL-1β level in the research group (139.04 ± 15.54 pg/mL) was significantly lower than that in the control group (156.35 ± 18.10 pg/mL), and the level of IL-10 in the research group (7.98 ± 1.01 ug/L) was higher than that in the control group (5.56 ± 0.96 ug/L) ( P < 0.05). The incidence of complications in the study group (4.65%) was significantly lower than that of the control group (18.60%; P < 0.05). CONCLUSION Endodontic therapy and periodontal treatment for patients with severe periodontitis can effectively reduce the levels of inflammatory factors in the GCF and the inflammatory reaction. In addition, it can improve the periodontal condition and the overall treatment effect, reduce the risk of complications, and ensure the safety of treatment.

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Comparison of apical periodontitis repair in endodontic treatment with calcium hydroxide-dressing and aPDT

Cited by 16 publications

References 30 publications

Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment

Retrospective clinical evaluation of root canal treatment with or without photodynamic therapy for necrotic teeth and teeth subjected to retreatment

Photosensitizers and Exposure Times To Light Showed Tissue Compatibility In Isogenic Mice

Comparison of dental pulp periodontal therapy and conventional simple periodontal therapy as treatment modalities for severe periodontitis

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