Comparison of antioxidant activities of different parts from snow chrysanthemum (Coreopsis tinctoria Nutt.) and identification of their natural antioxidants using high performance liquid chromatography coupled with diode array detection and mass spectrometry and 2,2′-azinobis(3-ethylbenzthiazoline-sulfonic acid)diammonium salt-based assay

Chen, L.X.; Hu, De Jin; Lam, Shing Chung; Ge, Liya; Wu, Ding‐Tao; Zhao, Jing; Long, Zerong; Yang, Wei-Qi; Fan, Bing; Li, Shao‐Ping

doi:10.1016/j.chroma.2015.10.037

Cited by 62 publications

(51 citation statements)

References 22 publications

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“…Snow chrysanthemum possesses higher antioxidant activity compared to Chrysanthemum morifolium. Therefore the research interest arises in snow chrysanthemum due to its excellent antioxidant activity 45 . Nowadays, Skin diseases induced by UV radiation such as skin cancer and Sun et al, 2016 photoaging become a global concern.…”

Section: Key Findings Referencementioning

confidence: 99%

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chae¹

2016

Biosci., Biotech. Res. Asia

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The Chrysanthemum is a well-known traditional Chinese medicinal herb which has been used as a drug for thousands of years. From the detailed literature survey it is determined that the dried flowers of Chrysanthemum contain organic groups such as alkanes, flavonoids, terpinoids, unsaturated fatty acids and polysaccharides which belongs to Secondary constituents in Phytochemicals classification. The knowledge and analysis of bioactive compounds present in the Chrysanthemums can be used for next generation drug development process. The developments of new drugs against diabetes and prostate cancer have become global concern. Hence the present study leads to identify the new strategies which are needed to develop multi-functional drugs against various human diseases using Chrysanthemum plant. Owing to antifungal, antibacterial and anti-inflammation activities, Chrysanthemum have much attention in the field of biomolecules research. In general Phytochemicals can be classified as primary and secondary constituents. One can understand the fascinating properties of biological compounds via phytochemical analysis which are present in the plants. Therefore, the present study gives a better understanding of phytochemical properties of Chrysanthemum and new foundations for the production of non-toxic and eco-friendly drugs of today and the future.

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Section: Key Findings Referencementioning

confidence: 99%

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chae¹

2016

Biosci., Biotech. Res. Asia

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“…And it tentatively indicated that there was a conversion relationship between this compound and the CQAs derivatives during the blossom. In our previous study, this compound did not exhibit relatively strong free radical scavenging activities . However, it was reported that spermine derivatives that were conjugated to cinnamic moieties might exhibit significant pharmacological activities, such as anti‐HIV and antidepressant activities and so on .…”

Section: Resultsmentioning

confidence: 89%

“…The optimization of HPLC conditions was performed using the mixed standards and CT01 samples. In our previous study, C. tinctoria extract could obtain a satisfactory separation by using an Eclipse XDB‐C 18 column (4.6 × 150 mm 2 , 5 μm), whereas the analysis time was too long . It was witnessed that it can obtain a shortened analysis time and a better resolution by using the column with smaller particle size (3.5 μm).…”

Section: Resultsmentioning

confidence: 99%

Chemical characteristics of different parts of Coreopsis tinctoria in China using microwave‐assisted extraction and high‐performance liquid chromatography followed by chemometric analysis

Lam

Liu

Chen

et al. 2016

J of Separation Science

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Coreopsis tinctoria, also called "snow chrysanthemum" in China, is a flower tea material that has been reported to possess excellent pharmacological properties such as antioxidant and antidiabetic activities. The chemical characteristics of different parts (flowers, buds, seeds, stems, and leaves) of C. tinctoria were investigated based on microwave-assisted extraction and the simultaneous determination of 13 major active compounds by high-performance liquid chromatography, including taxifolin-7-O-glucoside, chlorogenic acid, (R/S)-flavanomarein, isocoreopsin, quercetagetin-7-O-glucoside, isookanin, 5,7,3',5'-tetrahydroxyflavanone-7-O-glucoside, marein, 3,5-dicaffeoylquinic acid, coreopsin, okanin, 5,7,3',5'-tetrahydroxyflavanone, and N(1) ,N(5) ,N(10) ,N(14) -tetra-p-coumaroylspermine. Chemometric analysis based on the contents of investigated compounds from 13 samples showed that C. tinctoria and the related flower tea materials, Chrysanthemum morifolium cv "Hangju" and "Gongju," were in different clusters, and different parts (flowers, buds, seeds, stems, and leaves) of C. tinctoria were obviously different. This study is helpful for the quality control and pharmacological evaluation of different parts from C. tinctoria and its related products.

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“…However, either the DPPH assay or the ABTS assay could hardly indicate which types of compounds made up the major contribution towards the antioxidant effects in extracts of C. tinctoria (Wang and others ). Therefore, in the latest studies, HPLC combined with DPPH and ABTS assays were established for indicating the chemical composition of antioxidants in ethanol extracts of C. tinctoria (Chen and others ; Ma and others ). However, it is considered that the existing online HPLC‐DPPH and HPLC‐ABTS assays had several shortcomings, including long analysis time (more than 50 min in 1 run) and high consumption of organic solvents when analyzing multiple samples (Chen and others ; Ma and others ).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, in the latest studies, HPLC combined with DPPH and ABTS assays were established for indicating the chemical composition of antioxidants in ethanol extracts of C. tinctoria (Chen and others ; Ma and others ). However, it is considered that the existing online HPLC‐DPPH and HPLC‐ABTS assays had several shortcomings, including long analysis time (more than 50 min in 1 run) and high consumption of organic solvents when analyzing multiple samples (Chen and others ; Ma and others ). High‐performance thin‐layer chromatography (HPTLC) is the most popular used method for the identification of herbal medicinal products and pharmaceutical formulations (Shewiyo and others ).…”

Section: Introductionmentioning

confidence: 99%

Rapid Identification and Comparison of Compounds with Antioxidant Activity in Coreopsis tinctoria Herbal Tea by High‐Performance Thin‐Layer Chromatography Coupled with DPPH Bioautography and Densitometry

Lam

Zhao

et al. 2016

Journal of Food Science

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A simple and efficient method based on high-performance thin-layer chromatography coupled with 2,2-diphenyl-1-picrylhydrazyl (DPPH) bioautography (HPTLC-DPPH) was established for the screening and comparison of antioxidants in different parts of Coreopsis tinctoria herbal tea from different origins and other related herbal tea materials, which used Chrysanthemum morifolium cv. "Gongju" and "Hangju" in this study. Scanning densitometry after DPPH derivatization was applied for the determination of antioxidant capacities of isolated compounds in each sample. It is considered that ethanol extracts of C. tinctoria had stronger antioxidant activity and more characteristic bands than those of 2 compared samples, C. morifolium cv. "Gongju" and "Hangju." Chemometric analysis results showed that the combination of hierarchical clustering analysis and principal component analysis based on determined antioxidant capacities could be used for the discrimination of different parts of C. tinctoria and C. morifolium. Results showed that 7 compounds made up the major contributions of antioxidant activity in C. tinctoria, including okanin, isookanin, marein, flavanomarein, 5,7,3',5'-tetrahydroxyflavanone-7-O-glucoside, 3,5-dicaffeoylquinic acid, and chlorogenic acid. Therefore, 7 compounds were identified as major antioxidant biomarkers for quality control of C. tinctoria. Results demonstrated that the established method could be applied for the identification of C. tinctoria, and were beneficial for the bioactivity-based quality control of C. tinctoria.

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Cited by 62 publications

References 22 publications

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chemical characteristics of different parts of Coreopsis tinctoria in China using microwave‐assisted extraction and high‐performance liquid chromatography followed by chemometric analysis

Rapid Identification and Comparison of Compounds with Antioxidant Activity in Coreopsis tinctoria Herbal Tea by High‐Performance Thin‐Layer Chromatography Coupled with DPPH Bioautography and Densitometry

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