Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials

Abstract

Antimüllerian hormone was a stronger predictor of ovarian response to gonadotropin therapy than AFC at the study center level in both randomized trials utilizing GnRH agonist and GnRH antagonist protocols. Antral follicle count provided no added predictive value beyond AMH.

Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

“…In the current study, we demonstrate that inclusion of biomarkers known for their accurate prediction of ovarian response enhances live-birth prediction model performance beyond age and other baseline characteristics. Inclusion of AMH achieved optimal model performance compared with AFC or even the combination of AMH and AFC and is consistent with analyses of multicenter randomized controlled trial data demonstrating that the combination of biomarkers did not enhance response prediction over a single marker (15,31).…”

“…To date we have been able to assess the utility of AFC only, in clinic-specific prediction models, and demonstrated that its inclusion could improve model performance. However, owing to limited data, we were unable to assess its contribution relative to AMH, which has recently been shown in several randomized controlled trials to be a more accurate single biomarker of ovarian response (15,16). Furthermore, whether inclusion of both AMH and AFC can further enhance model performance is not known, particularly as clinicians frequently observe relative discordance between these two biomarkers.…”

Measurement of antral follicle count in patients undergoing in vitro fertilization treatment: results of a worldwide web-based survey

“…They failed to show an independent association between AFC and oocyte yield in either treatment arm, whereas AMH was the strongest predictor of ovarian response [16]. More recently, Nelson et al (2015) compared AFC with AMH as predictors of ovarian response in a secondary analysis of two multicenter trials involving 1205 patients undergoing GnRH antagonist and long-luteal agonist cycles. They found that AMH was more strongly correlated with oocyte yield than AFC [19].…”

“…More recently, Nelson et al (2015) compared AFC with AMH as predictors of ovarian response in a secondary analysis of two multicenter trials involving 1205 patients undergoing GnRH antagonist and long-luteal agonist cycles. They found that AMH was more strongly correlated with oocyte yield than AFC [19]. It should be noted that the value of AFC will likely be clinic-dependent.…”

Comparison of the Predictive Value of Antral Follicle Count, Anti-Müllerian Hormone and Follicle-Stimulating Hormone in Women Following GnRH-Antagonist Protocol for Intracytoplasmic Sperm Injection

“…Significance ( Markers of ovarian reserve are regularly used to predict poor ovarian response to gonadotrophin stimulation which is suspected in the presence of high levels of FSH and/or estradiol, or more recently on the basis of a low AFC or reduced levels of AMH [28].…”