Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

Nelson, Scott M.; Fleming, Richard; Gaudoin, Marco; Choi, ByoungSeon; Santo-Domingo, Kenny; Yao, Mylene

doi:10.1016/j.fertnstert.2015.04.032

Cited by 40 publications

(39 citation statements)

References 39 publications

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“…Combined, these AMH-associations suggest positive effects on clinical pregnancy and live birth rates up to “best” AMH levels but, because of increasing miscarriage rates, with highest AMH levels unfavorable effects on live birth rates. A currently widely held opinions is that AMH linearly reflects oocyte quantity and quality, both declining with advancing female age [ 27 , 28 ]. Here presented AMH observations, however, now suggest otherwise.…”

Section: Resultsmentioning

confidence: 99%

Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

et al. 2016

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BackgroundThough outcome models have been proposed previously, it is unknown whether cutoffs in clinical pregnancy and live birth rates at all ages are able to classify in vitro fertilization (IVF) patients into good-, intermediate- and poor prognosis.MethodsWe here in 3 infertile patient cohorts, involving 1247, 1514 and 632 women, built logistic regression models based on 3 functional ovarian reserve (FOR) parameters, including (1) number of good quality embryos, (2) follicle stimulating hormone (FSH, mIU/mL) and (3) anti-Müllerian hormone (AMH, ng/mL), determining whether clinical pregnancy and live birth rates can discriminate between good, intermediate and poor prognosis patients.ResultsAll models, indeed, allowed at all ages for separation by prognosis, though cut offs changed with age. In the embryo model, increasing embryo production resulted in linear improvement of IVF outcomes despite transfer of similar embryo numbers; in the FSH model outcomes and FSH levels related inversely, while the association of AMH followed a bell-shaped polynomial pattern, demonstrating “best” outcomes at mid-ranges. All 3 models demonstrated increasingly poor outcomes with advancing ages, though “best” AMH even above age 43 was still associated with unexpectedly good pregnancy and delivery outcomes. Excessively high AMH, in contrast, was at all ages associated with spiking miscarriage rates.ConclusionsAt varying peripheral serum concentrations, AMH, thus, demonstrates hithero unknown and contradictory effects on IVF outcomes, deserving at different concentrations investigation as a potential therapeutic agent, with pregnancy-supporting and pregnancy-interrupting properties.Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-016-0924-7) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

et al. 2016

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“…Evidence demonstrates a greater clinical value of AMH and AFC compared to FSH [42]. The AMH has better reliability than other markers to predict the ovarian reserve and the ovarian response to exogenous stimulation [43][44][45]. Ovarian reserve tests provide prognostic information about women at increased risk of DOR, such as women who: 1) are over 35 years old; 2) have a family history of premature ovarian failure; 3) have a past history of ovarian surgery or radiation; 4) have unexplained infertility [1].…”

Section: Discussionmentioning

confidence: 99%

Methods of evaluation of the ovarian reserve

Abdelazim¹,

Abu-Faza²,

Svetlana³

et al. 2018

jogi

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The chances of pregnancy decrease with the natural aging process of the infertile couple. During treatment of an infertile couple, the clinicians are usually asked questions about the chance of conception. Ovarian reserve describes the reproductive ability of the woman. An ideal ovarian reserve test should be affordable, convenient and sensitive. Ovarian reserve tests help to predict a poor response or hyper-response to ovarian stimulation and help to formulate the treatment plan in an infertile couple. Decreased ovarian reserve refers to women whose ovarian response to exogenous gonadotropin stimulation is reduced compared to similar women of the same age.

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“…The significant role of AMH and AFC in the prediction of live birth upon ovarian stimulation has been well documented through predictive algorithms containing these two parameters, as it would be expected. The final verdict regarding these two was that the prediction value of AMH combined with various patient related variables was higher in comparison to AFC (Nelson et al 2015).…”

Section: Afc and Reproductive Hormonesmentioning

confidence: 99%

Making IVF more effective through the evolution of prediction models: is prognosis the missing piece of the puzzle?

Simopoulou

Sfakianoudis²,

Antoniou

et al. 2018

Systems Biology in Reproductive Medicine

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IVF: In vitro fertilization; ART: assisted reproduction techniques; BMI: body mass index; OHSS: ovarian hyperstimulation syndrome; eSET: elective single embryo transfer; ESHRE: European Society of Human Reproduction and Embryology; mtDNA: mitochondrial DNA; nDNA: nuclear DNA; ICSI: intracytoplasmic sperm injection; MBR: multiple birth rates; LBR: live birth rates; SART: Society for Assisted Reproductive Technology Clinic Outcome Reporting System; AFC: antral follicle count; GnRH: gonadotrophin releasing hormone; FSH: follicle stimulating hormone; LH: luteinizing hormone; AMH: anti-Müllerian hormone; DHEA: dehydroepiandrosterone; PCOS: polycystic ovarian syndrome; NPCOS: non-polycystic ovarian syndrome; CE: cost-effectiveness; CC: clomiphene citrate; ORT: ovarian reserve test; EU: embryo-uterus; DET: double embryo transfer; CES: Cumulative Embryo Score; GES: Graduated Embryo Score; CSS: Combined Scoring System; MSEQ: Mean Score of Embryo Quality; IMC: integrated morphology cleavage; EFNB2: ephrin-B2; CAMK1D: calcium/calmodulin-dependent protein kinase 1D; GSTA4: glutathione S-transferase alpha 4; GSR: glutathione reductase; PGR: progesterone receptor; AMHR2: anti-Müllerian hormone receptor 2; LIF: leukemia inhibitory factor; sHLA-G: soluble human leukocyte antigen G.

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Antimüllerian hormone levels and antral follicle count as prognostic indicators in a personalized prediction model of live birth

Cited by 40 publications

References 39 publications

Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

Definition by FSH, AMH and embryo numbers of good-, intermediate- and poor-prognosis patients suggests previously unknown IVF outcome-determining factor associated with AMH

Methods of evaluation of the ovarian reserve

Making IVF more effective through the evolution of prediction models: is prognosis the missing piece of the puzzle?

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