Comparison of Antigens from Human and Chimpanzee Herpes-Type Virus-Infected Hemic Cell Lines

Stevens, David A.; Pry, Thomas W.; Blackham, Elizabeth A.; Manaker, Robert A.

doi:10.3181/00379727-133-34543

Cited by 17 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Investigators used the newly developed indirect immuno£uores-cence assay to detect antibodies cross-reactive to the EBV capsid antigen (VCA) in the serum of many Old World non-human primate species (Dunkel et al 1972;Frank et al 1976;Goldman et al 1968;Kalter et al 1972;Landon & Malan 1971;Levy et al 1971;Naito et al 1971;Stevens et al 1970;Werner et al 1972). The failure to detect EBV crossreactive antibodies in New World primates suggested that LCVs were restricted to humans and non-human Old World primates.…”

Section: Historical Perspectivementioning

confidence: 99%

Simian homologues of Epstein–Barr virus

Wang

Rivailler

Rao

et al. 2001

Phil. Trans. R. Soc. Lond. B

View full text Add to dashboard Cite

g-Herpesviruses closely related to the Epstein^Barr virus (EBV) are known to naturally infect Old World non-human primates and are classi¢ed in the same lymphocryptovirus (LCV) genera. LCV infecting humans and Old World primates share similar biology, and recent studies have demonstrated that these viruses share a similar repertoire of viral genes. Surprisingly, the latent infection genes associated with cell growth transformation demonstrate the most striking sequence divergence, but the functional mechanisms for these genes are generally well conserved. The recent discovery of LCVs naturally infecting New World primates has rewritten the old paradigm of LCV host range restriction to humans and Old World non-human primates, so that these viruses are more widespread than previously believed. However, the New World LCV genome has signi¢cant and interesting di¡erences from EBV and other Old World LCVs despite similar biological properties. Thus, the simian homologues of EBV can provide an important animal model for studying LCV pathogenesis, and the similarities and di¡erences that have evolved among these related viruses can provide a unique perspective towards a better understanding of EBV.

show abstract

Section: Historical Perspectivementioning

confidence: 99%

Simian homologues of Epstein–Barr virus

Wang

Rivailler

Rao

et al. 2001

Phil. Trans. R. Soc. Lond. B

View full text Add to dashboard Cite

show abstract

“…These simian herpesviruses share significant genetic, biologic, and pathogenic features with the human counterpart (reviewed in references 1 and 16). They readily immortalize isogeneric B cells in vitro (1,16,57), nearly all hosts are infected and seropositive by adulthood (11,12,28,29,33), virus transmission is associated with intimate contact (16), the virus maintains a latent infection for the life of the animal (16,32,53,56,57,63,64), and immunosuppression can lead to malignant proliferation of virus-infected B cells (15,19,34,64). Thus, these animals may provide a valuable in vivo model for EBV pathogenesis.…”

mentioning

confidence: 99%

5' Coding and regulatory region sequence divergence with conserved function of the Epstein-Barr virus LMP2A homolog in herpesvirus papio

Franken

Annis

Ali

et al. 1995

J Virol

View full text Add to dashboard Cite

B-lymphotropic herpesviruses naturally infecting Old World primates share biologic, epidemiologic, pathogenic, and molecular features with the human pathogen Epstein-Barr virus (EBV). These related gammaherpesviruses have colinear genomes with considerable nucleotide homology. The replicative cycle genes share a high degree of homology across species, whereas the transformation-associated EBV latent genes appear to be much more divergent. For example, the EBV BamHI Nhet fragment, which encodes all or part of the EBV latent infection membrane proteins, cross-hybridizes poorly to DNA from nonhuman primate B-lymphotropic herpesviruses. A viral DNA fragment corresponding to this region of the EBV genome was isolated from the baboon B-lymphotropic herpesvirus, herpesvirus papio, and used to clone a herpesvirus papio cDNA corresponding to EBV LMP2A. At least three tyrosine kinase interaction motifs are conserved despite significant amino acid divergence of the herpesvirus papio LMP2A first exon from the EBV homolog. Functionally, the herpesvirus papio LMP2A is tyrosine phosphorylated and induces tyrosine phosphorylation of cell proteins similar to EBV LMP2A. The 12 hydrophobic LMP2 transmembrane domains are well conserved. Two CBP (J) binding sites important for EBNA-2-induced transactivation of the LMP2A promoter are also present in the herpesvirus papio LMP2A promoter, and the simian LMP2A promoter is also responsive to EBV EBNA-2induced transactivation in human B cells. Thus, transcriptional regulation, splicing, kinase interaction sites, and tyrosine phosphorylation of the LMP2A homologs have been conserved despite significant sequence heterogeneity in the preterminal repeat regions of these human and nonhuman primate EBVs. The conservation of the LMP2 gene, despite its apparent nonessential role for in vitro EBV infection, suggests an important role for LMP2A in vivo. The similarities between these human and simian B-lymphotropic herpesviruses, and the LMP2 genes in particular, suggest that the function of LMP2 in vivo could be addressed by using recombinant LMP2A-mutant simian viruses and experimental infection of Old World primates.

show abstract

“…Neutralizing antibody could be detected in 5 of 12 inoculated rhesus and none of 16 controls. Serum samples from all animals in our colony studied at birth showed high titers of antibody cross reacting with EBV which were assumed to be due to maternal antibody [most adult monkeys in our colony at the time this study was initiated had antibodies to EBV or a closely related virus (t2, 23,38)]. These maternal antibodies generally disappeared between 4 and 7 weeks after birth.…”

Section: Resultsmentioning

confidence: 99%

“…Rhesus monkeys and chimpanzees were chosen for these studies because of their close phylogenetic relationship to humans, and because of the evidence that they are naturally infected with EBV or an immunologically similar variant (4,10,12,23,38). During the course of this study, a number of investigators attempted to produce tumors in monkeys with EBV.…”

Section: Discussionmentioning

confidence: 99%

Infection of rhesus monkeys and chimpanzees with Epstein-Barr virus

Levine

Leiseca

Hewetson

et al. 1980

Archives of Virology

Self Cite

View full text Add to dashboard Cite

Seventy-two nonhuman primates were entered into a long-term study to evaluate the pathogenicity of Epstein-Barr virus (EBV). Infectious virus was inoculated into 42 rhesus monkeys, 4 chimpanzees and 1 cynomolgus monkey. Immunostimulation or immunosuppression was attempted in 34 of these animals to enhance the oncogenic potential of the virus. Eleven inoculated animals were followed for more than 3 years and two were observed for 8 years. No tumors were observed in any of the animals; however, serological evaluation of the 47 inoculated primates and 25 matched controls indicated that at least 14 rhesus monkeys and the cynomolgus monkey were successfully infected with EBV. The potential use of rhesus monkeys as a model for EBV-induced disease in humans is discussed.

show abstract

Comparison of Antigens from Human and Chimpanzee Herpes-Type Virus-Infected Hemic Cell Lines

Cited by 17 publications

References 4 publications

Simian homologues of Epstein–Barr virus

Simian homologues of Epstein–Barr virus

5' Coding and regulatory region sequence divergence with conserved function of the Epstein-Barr virus LMP2A homolog in herpesvirus papio

Infection of rhesus monkeys and chimpanzees with Epstein-Barr virus

Contact Info

Product

Resources

About