Comparison of anesthetic agents on otoacoustic emissions in children: propofol vs ketamine

Güngör, Günay; Bozkurt, Pervin; Yener, Murat; Yılmaz, Yetkin Zeki; Sarı, Elif; Ataş, Ahmet; Yılar, Selma; Hayır, Duygu

doi:10.1111/pan.12936

Cited by 5 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propofol is a short‐acting intravenous anaesthetic reagent that is widely used for sedation and hypnosis during and after operation . It has advantages over other anaesthetic drugs by protecting the immune system from being inhibited, and neuron cells from oxidative stress and hypoxia injury .…”

Section: Introductionmentioning

confidence: 99%

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Chen

Wan

Liu

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

Substantial evidence has shown that the anaesthetics and adjuvants given in the preoperative, intraoperative or postoperative period can affect cancer recurrence and overall survival in cancer patients. 1 A number of retrospective studies and clinical trials suggest that local anaesthesia alone or its addition to the general anaesthesia reduces cancer metastasis and recurrence, and improves overall survival. 2-4 In contrast, other anaesthetics, such as opioids, are immunosuppressive and decrease the patient's defenses against tumour progression. 5 The roles of anaesthetics have gained increased attention due to their potential long-term effects on cancer patients. Propofol is a short-acting intravenous anaesthetic reagent that is widely used for sedation and hypnosis during and after operation. 6 It has advantages over other anaesthetic drugs by protecting the immune system from being inhibited, and neuron cells from oxidative stress and hypoxia injury. 7,8 Compared to volatile agents, propofol has a lower inflammatory response. 9 A retrospective analysis compared propofol

show abstract

Section: Introductionmentioning

confidence: 99%

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Chen

Wan

Liu

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…Propofol is a general sedative reagent and commonly used for induction and maintenance of general anesthesia [ 9 ]. It has advantages over other anesthetic drugs by protecting neuron and endothelial cells from oxidative stress and hypoxia injury [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Tan

Peng

et al. 2017

BMC Anesthesiol

View full text Add to dashboard Cite

BackgroundThe anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML).MethodsWe systematically examined the effect of propofol and its combination with BCR-ABL tyrosine kinase inhibitors (TKIs) in CML cell lines, patient progenitor cells and mouse xenograft model. We analyzed propofol’s underlying mechanism focusing on survival pathway in CML cells.ResultsWe show that propofol alone is active in inhibiting proliferation and inducing apoptosis in KBM-7, KU812 and K562 cells, and acts synergistically with imatinib or dasatinib, in in vitro cell culture system and in vivo xenograft model. In addition, propofol is more effective in inducing apoptosis and inhibiting colony formation in CML CD34 progenitor cells than normal bone marrow (NBM) counterparts. Combination of propofol and dasatinib significantly eliminates CML CD34 without affecting NBM CD34 cells. We further demonstrate that propofol suppresses phosphorylation of Akt, mTOR, S6 and 4EBP1 in K562. Overexpression of constitutively active Akt significantly reverses the inhibitory effects of propofol in K562, confirm that propofol acts on CML cells via inhibition of Akt/mTOR. Interestingly, the levels of p-Akt, p-mTOR and p-S6 are lower in cells treated with combination of propofol and imatinib than cells treated with propofol or imatinib alone, suggesting that propofol augments BCR-ABL TKI’s inhibitory effect via suppressing Akt/mTOR pathway.ConclusionOur work shows that propofol can be repurposed to for CML treatment. Our findings highlight the therapeutic value of Akt/mTOR in overcoming resistance to BCR-ABL TKI treatment in CML.Electronic supplementary materialThe online version of this article (10.1186/s12871-017-0423-2) contains supplementary material, which is available to authorized users.

show abstract

“…It was also reported to change the evoked otoacoustic emissions (OAE) thresholds [19] . In contrast, Gungor et al reported that transient evoked otoacoustic emissions (TEOAE) were not signi cantly affected after propofol [20].…”

Section: Discussionmentioning

confidence: 91%

Effect of propofol versus sevoflurane on auditory and cognitive functions: A randomized controlled trial

Fathy

Hussein

Koura

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Hearing loss and cognitive impairment are postoperative complications which need more awareness by anaesthesiologists. We aimed to study the possible deleterious effect of Propofol versus Sevoflurane on auditory function, attention and auditory memory. Methods This prospective randomized controlled trial was conducted on 80 patients who were candidate for elective laparoscopic cholecystectomy under general anesthesia; 40 patients received Propofol (propofol group ), and 40 patients received Sevoflurane (sevoflurane group). The included patients were assessed before and 1 week postoperative regarding the auditory functions by using the auditory brainstem response (ABR) and the attention and auditory memory by using the Paced Auditory Serial Addition Test (PASAT) and Paired Associate Learning test (PALT) scales. Results There was no statistically significant difference between both groups in either age (P-value = 0.537) or sex (P-value = 0.175). In Propofol group, the postoperative values of LT ABR-I and III were significantly higher than the preoperative ones (p value < 0.001, 0.003), all the postoperative RT ABR waves were significantly higher than the preoperative ones (P < 0.05). In Sevoflurane group, the postoperative values for LTABR- I, III, III-V were significantly higher than the preoperative ones with p value (0.012, 0.008 and 0.009) and the postoperative values for RTABR-III, V, I-III, and III-V were significantly higher than preoperative values ( p = 0.041, 0.029, 0.005 and < 0.001). There was no statistically significant differences between the Propofol and Sevoflurane groups in all waves of ABR in both sides ( P > 0.05). There was a significant worsening between pre and postoperative PASAT scores in Propofol and Sevoflurane groups respectively with p value (< 0.001) with no statistically significant difference between both groups (P-value = 0.906).Also, There was a significant worsening between pre and postoperative PALT scores in Propofol group only (p value = 0.01) with a statistically significant difference between both groups (P-value = 0.038). Conclusion There was a statistically significant postoperative impairment in auditory function, attention and auditory memory following anesthesia with both propofol and Sevoflurane with no significant difference between the two drugs. The protocol of this study was registered in ClinicalTrials.gov. The identification number is NCT04874545.

show abstract

Comparison of anesthetic agents on otoacoustic emissions in children: propofol vs ketamine

Abstract: DPOAE measurements were reduced similarly by propofol and ketamine anesthesia. Lower false outcome ratio in TEOAE measurements made propofol a better option than ketamine.

Cited by 5 publications

References 14 publications

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Effect of propofol versus sevoflurane on auditory and cognitive functions: A randomized controlled trial

Contact Info

Product

Resources

About